Missing mention of pawpaw's annonacin content, which causes Parkinsonism. https://pubmed.ncbi.nlm.nih.gov/22130466/ "Pawpaw fruit contains a high concentration of annonacin, which is toxic to cortical neurons." https://www.mskcc.org/cancer-care/integrative-medicine/herbs... "Pawpaw fruit contains high concentrations of annonacin, which is toxic to nerve cells. In addition there have been case reports of possibly rela…
Probably not a huge issue as long as you only eat it every so often. But I wonder about the possibility of producing varieties of pawpaw (or soursop or other related Annonas) that don't produce annonacin. Probably could be done with genetic engineering, or much more slowly with selective breeding. Given that there are places where people consume Annonas very often, and that this may lead to alarmingly high rates of p…
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691614/
"The paucity of adequate studies, particularly related to long‐term use of A. muricata supplements, currently does not allow the establishment of a safe intake level."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092620/
"Cognitive performance assessed with the MDRS worsens above a cumulative consumption threshold of 0.2 fruit‐years of Annonaceae fruit/juice (ie, one fruit every 5 days for 1 year) or with consumption of any quantity of Annonaceae herbal tea."