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AstraZeneca unveils successes in treatment of lung cancer

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11–20 of 147 posts

Re: AstraZeneca unveils successes in treatment of lung cancer

#11

Hey onco-nosology nerds: Is there a cell-typed unambiguous classification system, research, and clinical treatment protocol nexus attempting to capture and disseminate information on all cancer types in a more precise and organized effort?

More precise and organised than what?

Re: AstraZeneca unveils successes in treatment of lung cancer

#12

Didn’t Cuba have a vaccine for lung cancer? I seem to recall seeing one in a documentary (maybe a Michael Moore film?)

My father died of lung cancer. I also ran a failed medical tourism company which sent people to get this treatment in Cuba. More modern versions of the Cuban treatment are now few approved in the USA as immunotherapy. Didn’t save my dad

Sorry about your Dad but did it help other people? How many did you send and how many had positive outcomes in terms of prolonged life above the expected outcome?

Re: AstraZeneca unveils successes in treatment of lung cancer

#13
“Statistically significant and highly clinically meaningful” perhaps, but not so much that they can say what that actually means.

My understanding is that of all cancer drugs approved by the FDA between 2000-2016 (around 90 drugs), the median life extension was just over 2 months...

Re: AstraZeneca unveils successes in treatment of lung cancer

#16
post #13

“Statistically significant and highly clinically meaningful” perhaps, but not so much that they can say what that actually means. My understanding is that of all cancer drugs approved by the FDA between 2000-2016 (around 90 drugs), the median life extension was just over 2 months...

The distribution skews right on these things. Median probably is not the right way to think about it

Re: AstraZeneca unveils successes in treatment of lung cancer

#17

Didn’t Cuba have a vaccine for lung cancer? I seem to recall seeing one in a documentary (maybe a Michael Moore film?)

Still in trials in the US/EU, but it's not useful for anyone over 60 because the immune system is too weak.

Re: AstraZeneca unveils successes in treatment of lung cancer

#18
post #13

“Statistically significant and highly clinically meaningful” perhaps, but not so much that they can say what that actually means. My understanding is that of all cancer drugs approved by the FDA between 2000-2016 (around 90 drugs), the median life extension was just over 2 months...

Sad stats truth: statistical significance does not say much about effect size, and it's misinterpreted by ~half articles.

See https://www.nature.com/articles/d41586-019-00857-9 for more

Re: AstraZeneca unveils successes in treatment of lung cancer

#20
post #13

“Statistically significant and highly clinically meaningful” perhaps, but not so much that they can say what that actually means. My understanding is that of all cancer drugs approved by the FDA between 2000-2016 (around 90 drugs), the median life extension was just over 2 months...

I think that is a perverse incentive of Medicare so it gets covered in treatment.

The may work better, but the drugs only run the studies to that threshold.

My mom died of lung cancer like 10 years ago and the immunotherapy drugs like keytuda all has those disclaimers.

Her pd1 wasn't a good fit, but some like Jimmy Carter responded really well

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