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$5 device tests for breast cancer in under 5 seconds: study

studyfinds.org

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Re: $5 device tests for breast cancer in under 5 seconds: study

#31
post #24

As a reference. Currently an MRI scan can go from $400-$2000 (mostly covered by insurance) https://scan.com/body-parts/breast An MRI machine cost arounds $350.000 on average. https://www.blockimaging.com

A device such as this would never replace an MRI scan. The information provided is for screening purposes, at best.

Also, diagnosis would typically be done using a mammography. The cost of such a scan is lower - around $100[0].

[0]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142190/

Re: $5 device tests for breast cancer in under 5 seconds: study

#32
post #25

Earlier quoted context omitted.

First standout thing I noticed is the “patern generator” array of DIPs - admittedly without having dived into the paper, any answers from the hive mind what they’re doing?

Breast cancer is a terrible disease, and I don't mean to be a downer but my BS detector is screaming on this one. I'd give the device image a pass if were just a journalist grabbing a stock PCB image, but that doesn't seem to be the case here. Anyone with even a trivial knowledge of electronics would be amused by the callouts. And all for just $5? After Theranos I guess I'm a bit sceptical of claims such as this.

Yeah, this looks like an Apple IIe logic board to me.

Re: $5 device tests for breast cancer in under 5 seconds: study

#33
post #13

Cool how they're using BNC connectors and ICs from the 1980's /s

First standout thing I noticed is the “patern generator” array of DIPs - admittedly without having dived into the paper, any answers from the hive mind what they’re doing?

From the paper:

> Synchronous voltage pulses are sent to both the electrode of the strip connecting to the gate and drain electrodes of the MOSFET. The drain pulse is applied for around 1.1 ms at a constant voltage. The gate pulse starts at 40 μs after the drain pulse and ends at 40 μs before the end of the drain pulse.

> the antigen-antibody complexes undergo stretching and contracting, akin to double springs, in response to a pulsed gate electric field. This motion across the antibody-antigen structure, corresponding to the pulse voltage applied on the test strip, induces an alteration in the protein's conformation, resulting in a time-dependent electric field applied to the MOSFET gate. Consequently, a springlike pattern emerges in the drain voltage waveform due to the external connection between the sensor strip and the MOSFET's gate electrode.

So they shake ‘em just so, and listen to the response…

ICs are perhaps variable timing & pulse-shaping logic?

Re: $5 device tests for breast cancer in under 5 seconds: study

#34
post #4
post #3

[flagged]

> Scientists say a new handheld device is capable of testing for breast cancer in less than five seconds using just a small sample of saliva Second sentence in the the linked post

So, reading an actual publication [1], all this test does is identify if the patient has the BRCA biomarker for breast cancer. It doesn't actually detect if the patient has breast cancer. The title is misleading, as is your post.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249990/

Re: $5 device tests for breast cancer in under 5 seconds: study

#35
post #25

Earlier quoted context omitted.

Breast cancer is a terrible disease, and I don't mean to be a downer but my BS detector is screaming on this one. I'd give the device image a pass if were just a journalist grabbing a stock PCB image, but that doesn't seem to be the case here. Anyone with even a trivial knowledge of electronics would be amused by the callouts. And all for just $5? After Theranos I guess I'm a bit sceptical of claims such as this.

Yeah, this looks like an Apple IIe logic board to me.

Commodity logic ICs ubiquitous and totally capable if needs are well-matched; it’s perhaps a deliberate prototype engineering/development choice.

Re: $5 device tests for breast cancer in under 5 seconds: study

#36

Press release: https://publishing.aip.org/publications/latest-content/would... Actual publication: https://pubs.aip.org/avs/jvb/article/42/2/023202/3262988/Hig... Experiment size is literally N=21, with 4 healthy participants, 3 in-situ breast cancers, and 14 invasive breast cancers. N=21 might as well be useless in my opinion. You can't draw any meaningful conclusions about statistical power of this test; if your pr…

[deleted]

Re: $5 device tests for breast cancer in under 5 seconds: study

#37

Press release: https://publishing.aip.org/publications/latest-content/would... Actual publication: https://pubs.aip.org/avs/jvb/article/42/2/023202/3262988/Hig... Experiment size is literally N=21, with 4 healthy participants, 3 in-situ breast cancers, and 14 invasive breast cancers. N=21 might as well be useless in my opinion. You can't draw any meaningful conclusions about statistical power of this test; if your pr…

> We tried it with 21 people

The new Theranos is here again

Re: $5 device tests for breast cancer in under 5 seconds: study

#38

Would a US company have enough financial incentive to front the cost of FDA approval in the US? I'm guessing it is expensive to jump through all of the hoops. Without a patent, why would a company pay for this?

As a non-invasive diagnostic equipment, let us say it is akin to a pregnancy test, or a creatine in urine test. That puts it in Class 1, and may be exempt from a lot of the hoops a medicine would go through. There are a little over 6,100 hospitals in the US at any given time. That means roughly $30,000 in cost to produce to provide every hospital with one, using the cheapest of cheapest parts. Presumably, you'd want…

Huh? The electronics is cheap and trivial. All the science is in those strips.
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