Worth remembering that Linus Pauling went off the deep end on Vitamin C. Not that he faked stuff, but that even very smart people get sucked into wierd science sometimes. So leaping from this, to Semanza is emperor's-new-clothes is pushing too far. If he's moved into a space where marginal behaviour around research is normalised thats really bad but it doesn't have to mean his Nobel wasn't warranted, that depends on…
Einstein's discovery of relativity is something everybody takes for granted now, but think about how exceptionally ridiculous the notion that light travels at the same rate of speed from all perspectives is; or how the universe will bend over backwards, including having people 'advance through time' at different rates of speed or literally physically change the distance between things, in order to maintain this perce…
It is entirely reasonable for any physicist (indeed, Maxwell himself could've done it with enough time), to work through the consequences of a non-relativistic equation for the speed of light.
This approach is routine in physics, and there's nothing in it that would appear crazy or unusual. Physicsts do not simply just pluck crazy ideas from their imagination and, from-nothing, deduce possible consequences. This is a myth, and insofar as people do that, they're cranks.
The imagination of a phyiscist is heavily guided by the totality of physics that has been developed. Einstein did not simply say, "what if the speed of light was fixed?"
He said, 'given we have good reasons to suppose it is, what are the concequences on relativity ?'