It's always encouraging to see progress in disease prevention. As a young person, I'm looking forward to what the medical field will be like when I'm 70.
its not disease prevention its correlation.
Protein biomarkers predict dementia 15 years before diagnosis in new study
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Re: Protein biomarkers predict dementia 15 years before diagnosis in new study
#12It's always encouraging to see progress in disease prevention. As a young person, I'm looking forward to what the medical field will be like when I'm 70.
its not disease prevention its correlation.
Finding a novel correlate that precedes the other observed effects of the disease in question is progress in prevention.
Re: Protein biomarkers predict dementia 15 years before diagnosis in new study
#13Earlier quoted context omitted.
its not disease prevention its correlation.
Finding a novel correlate that precedes the other observed effects of the disease in question is progress in prevention.
people thought for years that amyloid plaques were driving the disease only to be proven utterly wrong
you might want to have a bit of humility when dealing with complex systems
Re: Protein biomarkers predict dementia 15 years before diagnosis in new study
#14GFAP as dementia biomarker isn't a new discovery. Here's a 2023 meta-analysis that used papers as old as 2020.
Re: Protein biomarkers predict dementia 15 years before diagnosis in new study
#15Earlier quoted context omitted.
Finding a novel correlate that precedes the other observed effects of the disease in question is progress in prevention.
people thought for years that amyloid plaques were driving the disease only to be proven utterly wrong you might want to have a bit of humility when dealing with complex systems
Hmm. Are you saying that the fact that some knowledge is wrong means that it doesn’t represent progress?
Correlation isn’t “cure” — we don’t even know if it’s predictive — but that doesn’t mean it’s not progress.
Re: Protein biomarkers predict dementia 15 years before diagnosis in new study
#16Now is there something that can be done early or is it 15 extra years of suffering
From what I understand, the medicine available is fairly successful at staving off further disease progression but the normal late stage diagnosis often means it’s far too late. This might make outcomes significantly better if it works as well as reported.
the medicine available is just cherry picking clinical trial results to make it look better than placebo but it hardly does anything
Re: Protein biomarkers predict dementia 15 years before diagnosis in new study
#17Earlier quoted context omitted.
people thought for years that amyloid plaques were driving the disease only to be proven utterly wrong you might want to have a bit of humility when dealing with complex systems
Hmm. Are you saying that the fact that some knowledge is wrong means that it doesn’t represent progress? Correlation isn’t “cure” — we don’t even know if it’s predictive — but that doesn’t mean it’s not progress.
progress is measured by:
- identifying mechanism of action
- identifying therapeutic levers
- testing drugs and ahow that they can do something
we are not even at the first step with these biomarkers. observational studies are super noisy
Re: Protein biomarkers predict dementia 15 years before diagnosis in new study
#18I can't wait until we all find out it is from dentists or people picking their noses.
Re: Protein biomarkers predict dementia 15 years before diagnosis in new study
#19I can't wait until we all find out it is from dentists or people picking their noses.
Why would it be from dentists?
Re: Protein biomarkers predict dementia 15 years before diagnosis in new study
#20I can't wait until we all find out it is from dentists or people picking their noses.
Why would it be from dentists?
prions "Oral manifestations are rare. Evidence suggests that the risk of transmission and acquisition of a prion infection as a result of dental treatment is rare, if appropriate infection control measures are maintained."
https://www.sciencedirect.com/science/article/abs/pii/S00028...
nose picking https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669446/