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Alzheimer’s cases tied to no-longer-used medical procedure

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Re: Alzheimer’s cases tied to no-longer-used medical procedure

#131

Post by darkclouds »

axus wrote: post #38
eigenvalue wrote: post #35

I wonder what other stuff is being unwittingly transferred during standard blood transfusions. I've seen some interesting research about the "signalling" power of blood from both older and younger donors, with the "young blood" causing a slow down of senescence in cells, and the "old blood" causing a speed-up in senescence. Any time you take biological material out of other human beings and put them in a different bo…

My mom developed an allergy to eggs after a blood transfusion. She long regretted never being able to eat another chocolate eclair.

[dead]

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#132

Post by fbdab103 »

withinboredom wrote: post #74
axus wrote: post #38

Earlier quoted context omitted.

My mom developed an allergy to eggs after a blood transfusion. She long regretted never being able to eat another chocolate eclair.

You are supposed to declare your issues before (or at least after) you give blood. Kinda messed up that whoever donated that blood didn't report it. Then again, I'm glad the blood was available...

Some 30% of people have allergies. It can already be challenging to source enough blood with the current eligible population.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#133

Post by fbdab103 »

eigenvalue wrote: post #48
q1w2 wrote: post #41

Earlier quoted context omitted.

Not only blood transfusions, but ligament/tendon transplants from cadavers are extremely common for people who tear their ACL. It would be a disaster if this type of surgery also transmitted some prior/protein misfolding disease decades later. Millions would be impacted. The practice stared in the 1980s, but really only became popular in the early 2000s with the boom in arthroscopic surgery standardization. Hopefully…

Oh man, I bet you’re right and enough time hasn’t gone by to see the fallout from it! I bet rich people will start bidding up tendons and ligaments from younger cadavers (probably mostly motorcycle accident victims). Although given that so many of those have toxoplasmosis, maybe that’s also not great…

One estimate says that 30-50% of all human beings have toxoplasmosis, so I would put that as pretty low on the list of risks.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963851/

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#134

Post by hirvi74 »

scythe wrote: post #123
elzbardico wrote: post #116

Earlier quoted context omitted.

We can't conclude that the donor had an egg allergy. The immune system is complicated as hell, it could be the case that he had some weird protein circulating on his blood that was recognized by her immune system, and by chance this protein was structurally close enough to some egg protein that now eggs trigger an immune response on her.

Worth noting that the most prevalent protein in blood is albumin, and the major protein in eggs is, yep, albumin.

Are you implying there is a connection? Even if it's just for nonsense, I'd love to read it. Because other prevalent commonalities, you could make the same argument about water, for example.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#135

Post by BurningFrog »

axus wrote: post #38
eigenvalue wrote: post #35

I wonder what other stuff is being unwittingly transferred during standard blood transfusions. I've seen some interesting research about the "signalling" power of blood from both older and younger donors, with the "young blood" causing a slow down of senescence in cells, and the "old blood" causing a speed-up in senescence. Any time you take biological material out of other human beings and put them in a different bo…

My mom developed an allergy to eggs after a blood transfusion. She long regretted never being able to eat another chocolate eclair.

Killjoy note that the allergy may well be unrelated to the transfusion, despite occurring after it.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#136

Post by Gare »

LASR wrote: post #101

I wonder what other practices from decades ago are lurking to be discovered as catastrophic to currently living people. I remember reading about cattle rearing practices a while ago that might be responsible for some prion related diseases. Can’t remember the exact source. These things get you from entirely unrelated sources.

There was a whole epidemic: https://en.wikipedia.org/wiki/United_Kingdom_BSE_outbreak

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#137

Post by klipt »

goku12 wrote: post #102
diob wrote: post #26

Earlier quoted context omitted.

It mentions brain proteins contaminating it, makes me think of prions.

The article mentions that the procedure was banned due to incidence of Creutzfeldt-Jakob disease. That is a prion disease.

They still use pieces of cadaver for other surgeries. E.g. gum and bone transplants done by periodontists. Seems risky to me.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#138

Post by woleium »

klipt wrote: post #137
goku12 wrote: post #102

Earlier quoted context omitted.

The article mentions that the procedure was banned due to incidence of Creutzfeldt-Jakob disease. That is a prion disease.

They still use pieces of cadaver for other surgeries. E.g. gum and bone transplants done by periodontists. Seems risky to me.

as long as it’s not spine or brain matter it’s probably okay. During the mad cow outbreak (BSE, the bovine equivalent of CJD) in the UK, they banned “beef on the bone” but not all beef.

Re: Alzheimer’s cases tied to no-longer-used medical procedure

#139

Post by djmips »

klipt wrote: post #137
goku12 wrote: post #102

Earlier quoted context omitted.

The article mentions that the procedure was banned due to incidence of Creutzfeldt-Jakob disease. That is a prion disease.

They still use pieces of cadaver for other surgeries. E.g. gum and bone transplants done by periodontists. Seems risky to me.

Might depend on the age of the patient.
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