In quantum electrodynamics there is this problem: if you imagine an electron is a little sphere like the ball on a Van de Graff generator, there is a certain amount of energy in the electric field around it. As the radius gets tiny the field in the space immediately around it gets stronger so if you integrate it the energy of the EM field becomes infinite as the radius goes to zero…. We’ve got no evidence that the electron is more than a point, however.
We use a trick called renormalization which, in this case, is recognizing that the mass of the electron has a term from the EM field. We’d assume that the EM theory is not completely true but that below some distance the theory breaks down. Working in momentum space there is a certain momentum that corresponds to the cutoff distance so we just don’t integrate beyond that. You can vary the cutoff and also vary the other parameters of the theory (such as the bare mass of the electron) so the theory gives the same answers at macroscopic distances so it doesn’t matter where you put the cutoff.
Thus it does not matter much what the “true” theory is whether space is discrete or the electron really is a little ball or the EM field merges with the other forces at high energy to make some different force that (slowly) eats protons or quantum gravity or whatever.
Discretization is problematic in a relativistic world because it breaks Lorenz invariance. That is, if I am moving quickly I would see the gap between the “pixels” get smaller. Now maybe the pixels can be non-Lorenz invariant but can “fake it” at low energies and large sizes but when the energy gets large you’d expect to see some evidence of the grain. Even if the gap was the Planck length you’d probably see things get weird at much lower energies, such as those of the highest energy cosmic rays. There has been a lot of research on that and there is no clear evidence of relativity being broken but it is still highly mysterious
https://en.wikipedia.org/wiki/Greisen%E2%80%93Zatsepin%E2%80...
for instance Lorenz violation might allow particles to bypass that GZK limit.