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Too much serendipity

lesswrong.com

21–30 of 110 posts

Re: Too much serendipity

#21

I loved the writing but I don't get the point or the title. Am I supposed to infer some sort of conspiracy theory? or is it just supposed to be funny?

I think the author suggests that chemical-psychological research is quite inefficient, given that so many discoveries were random discoveries rather than products of systematic search and invention.

Re: Too much serendipity

#22
This poses the opposite question: What might we have missed? Maybe there are some reverse-accidents, some significant random discoveries that, due to their randomness, didn't happen.

Re: Too much serendipity

#23

What a fabulous analysis! The serendipity is remarkably high! I suppose penicillin might be a good addition to the list of powerful compounds discovered by happenstance? Does this mean that innovation is basically a brute force calculation? Humans simply trying permutations until something hits?

It’s much smarter than random, more like a guided search.

Re: Too much serendipity

#24
post #17

What a fabulous analysis! The serendipity is remarkably high! I suppose penicillin might be a good addition to the list of powerful compounds discovered by happenstance? Does this mean that innovation is basically a brute force calculation? Humans simply trying permutations until something hits?

How did we ever figure out that aspens and willows have aspirin analogs in their bark? Boredom? Starvation food? Psychedelic mushrooms make sense. You see it, you eat it. Willow bark tea is a whole process.

Makes you wonder about tobacco.

Hey, all the bugs that are eating that plant are dying. Let's see what happens if we smoke it.

Re: Too much serendipity

#25
I recently learned that anesthesia is the same. Not only has no anesthesia ever been developed except through "serendipity." Not only that, but anesthesia that works for humans also effect a wide range of things including plants and bacteria. But why is an active area of research. There are even speculations that there may be quantum effects involved. Biology and chemistry are insanely complex.

Re: Too much serendipity

#26
post #6
post #3

Earlier quoted context omitted.

Yes, to my taste, all the sweeteners have an aftertaste and an odor including stevia.

Re stevia, apparently how you taste it is determined by how sensitive your bitter taste receptors happen to be. It’s somehow also related to why some people can’t stand cilantro, for example. For me, stevia is simply sweet with no aftertaste so I guess I’m lucky in this regard.

You are! As one who identifies as keto, I have experience with a wide range of artificial sweeteners. Stevia is one of my favorites but I can definitely taste the bitterness. Which is why I only use it either in combination with other sweeteners (e.g. Erythritol), or in places where only a slight amount of sweetness is desired.

Edit: I just had a thought: are we talking about putting it in coffee here? Because the bitterness of coffee and the bitterness of Stevia are pretty close and I can see the former masking the latter easily.

Re: Too much serendipity

#27
post #20
post #10

Earlier quoted context omitted.

Considering how we all seem to be the product of millions of years of hit-or-miss natural selection, it feels almost natural that our advancements have also had a great deal of luck/improbability.

Some homebrewers will wax nostalgic about how the human sense of smell/taste can detect almost all of the ways that fermentation can go wrong and make it toxic. But we also keep pushing back earliest dates for precursors to civilization, I start to wonder if maybe there aren't graveyards of people who couldn't distinguish thymol from ethanol and selected themselves out of human history via acute liver failure.

Animals do eat fermented food, through fallen/rotting fruits, so perhaps the thymol sensitivity predates hominids.

Re: Too much serendipity

#28
I can’t imagine someone looking at these two molecules and thinking “surely they taste the same”.

I think that's more of a shortcoming of our method of diagramming molecules. It might be more apparent if we had 3D visualizations of the molecules and the receptors.

Re: Too much serendipity

#29
post #20
post #10

Earlier quoted context omitted.

Considering how we all seem to be the product of millions of years of hit-or-miss natural selection, it feels almost natural that our advancements have also had a great deal of luck/improbability.

Some homebrewers will wax nostalgic about how the human sense of smell/taste can detect almost all of the ways that fermentation can go wrong and make it toxic. But we also keep pushing back earliest dates for precursors to civilization, I start to wonder if maybe there aren't graveyards of people who couldn't distinguish thymol from ethanol and selected themselves out of human history via acute liver failure.

Yeah exactly this is not just random, it’s “guided search” as commented by a sibling

Re: Too much serendipity

#30

I recently learned that anesthesia is the same. Not only has no anesthesia ever been developed except through "serendipity." Not only that, but anesthesia that works for humans also effect a wide range of things including plants and bacteria. But why is an active area of research. There are even speculations that there may be quantum effects involved. Biology and chemistry are insanely complex.

How do you determine whether a plant or bacterium is anesthetized?
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