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When America first dropped acid

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101–110 of 185 posts

Re: When America first dropped acid

#101

Earlier quoted context omitted.

I disagree, but ignoring this somewhat, I offer this: One remarkable thing is how the hippie stuff often induced by chemical manipulation of serotonin receptors mirrors a lot of religious messages. You can take slogans like "peace on earth, love your neighbor, love is all you need" and say, is that hippie stuff? Or is it, say... The message attributed to Jesus? In that sense, you don't really need the drugs or counte…

Maybe because psychedelics wake up the part of the human psyche that understands religion

That doesn't seem right.

I think of the brain as a "rationalization machine". It observes environmental inputs, and reflexively seeks to ascribe a cause for those inputs. In so doing, a causal model of the world is constructed (whether accurate or not), allowing the agent to make intelligent decisions about what actions to take in order to produce desired outcomes.

What hallucinogenic drugs tend to do is overwhelm the brain with sensory inputs that are sui generis and cannot be folded neatly into a pre-existing causal model of reality, but that are so numerous that they cannot simply be ignored.

So the "protective mechanism" of the brain, rather than abandoning or risking damage to this highly valuable causal model of reality, is to shunt these experiences over into an "other" category of mystical and religious significance. The fact that these experiences are inexplicable, rather than being an indication of any "malfunction" in the brain which might prompt us to doubt our perception in general, is instead proof of their cause: the incomprehensible divine.

This isn't academic, just my 2c.

Re: When America first dropped acid

#102

Author of the book under review here. AMA! One thing I thought would be helpful is to link to the YouTube video described in the opening paragraph: https://www.youtube.com/watch?v=UMF-cyHAaSs It's from a 1957 CBS documentary series called "Focus on Sanity" that featured interviews with Aldous Huxley and Gerald Heard, among others. I found it fascinating and my questions about it were actually one of the motive forces…

Excellent find. I heard perhaps urban folklore from an old-timer former journalist that the LSD trade was monopolized by a single criminal syndicate in the 50's. There are still some haunts with local regulars not overrun with suits, squares, or tourists.

Why would a criminal syndicate in the 50s monopolize a drug that was not illegal at that time?

Re: When America first dropped acid

#103

Earlier quoted context omitted.

Maybe because psychedelics wake up the part of the human psyche that understands religion

That doesn't seem right. I think of the brain as a "rationalization machine". It observes environmental inputs, and reflexively seeks to ascribe a cause for those inputs. In so doing, a causal model of the world is constructed (whether accurate or not), allowing the agent to make intelligent decisions about what actions to take in order to produce desired outcomes. What hallucinogenic drugs tend to do is overwhelm th…

At the end of the day, you can either see a beautiful thing and share it with a bunch of people. Or you can see an ugly mechanistic thing and think that you're smarter than the people seeing the beautiful thing

I don't think whichever one you see is a choice either, more like the yanny vs laurel thing

At one point I made the same argument you make. Now I don't see it that way. And I feel much better honestly

Re: When America first dropped acid

#105

Earlier quoted context omitted.

Yes, this is the first I've heard of this but I would be interested in learning about it.

Psilocybin is a partial 5-HT2B receptor agonist. 5-HT2B receptor agonism causes deposits of collagen in heart valves (which will lead to valve disease). This is true for LSD, MDMA, and psilocybin. A note is that psilocybin is only a partial agonist, and the dosages taken for micro-dosing may not be comparable to something like fenfluramine (a drug which does cause heart valve dysfunction for certain). There was a dru…

The risk comes from taking the 2b agonist regularly, that's why it causes fibrosis. Not only is taking the larger dose safer as long as there are no preexisting cardiovascular issues but microdosing has been shown to be no better than placebo

Microdoses also don't inspire hippocampal neurogenesis whereas larger doses do

Microdosing is not only not beneficial but it may be actively harmful

"...it is possible that chronic microdosing may carry a risk of fibrosis and VHD, which should be assessed in future studies. There is converging evidence that simulation of the 5-HT2BR over several months may lead to the development of fibrosis. Duration of intake plays a major role in drug-induced VHD, even if the substance is not taken daily (Connolly et al., 1997; Schade et al., 2007)."

https://journals.sagepub.com/doi/full/10.1177/02698811231225...

Re: When America first dropped acid

#106

Earlier quoted context omitted.

Unless we are defining that “ideology” very narrowly, the sheer volume of cultural output (fashion, music, cinema, etc) would be a clear counterpoint.

How long did that period last? It died very fast, and was really only 5 years at maximum. Probably not much longer than the time that covid started until now. A flash in the pan.

There’s a related occurrence of the same principle — we have had movies/stories about the wild west for longer than the archetype frontier period existed.

Re: When America first dropped acid

#107

I take psychedelics a few times a year. I'm good with LSD once a year and I'm ok skipping it. I enjoy low (not micro) doses of mushrooms a few times each summer. Both have been very good for my sobriety. They aren't for everyone though. Great to see this becoming mainstream. Sad to see the number of charlatans and the industry has popped up around it. I hope that we're able to safely get these substances to those tha…

The effects of low doses of mushrooms/MDMA make me wonder if we have been going about it all wrong. You can easily take 20% of the normal amount and have a pleasant and noticeable effect but still be highly functional. It is like our "normal" dose for those drugs is the equivalent of 6+ drinks, and the idea of only having a beer or two is painted as a waste.

For the psychedelics this is very true, I enjoy mostly low doses. But I am not so sure about the MDMA. If I didn't have enough to get "over the hill" it always felt it's about to come on now but it never does it's just a very dissapointing limbo state. Even worse, redosing after that won't get you the full effect either for that night (maybe because some serotonin was already depleted at that point).

Re: When America first dropped acid

#108

Earlier quoted context omitted.

That doesn't seem right. I think of the brain as a "rationalization machine". It observes environmental inputs, and reflexively seeks to ascribe a cause for those inputs. In so doing, a causal model of the world is constructed (whether accurate or not), allowing the agent to make intelligent decisions about what actions to take in order to produce desired outcomes. What hallucinogenic drugs tend to do is overwhelm th…

At the end of the day, you can either see a beautiful thing and share it with a bunch of people. Or you can see an ugly mechanistic thing and think that you're smarter than the people seeing the beautiful thing I don't think whichever one you see is a choice either, more like the yanny vs laurel thing At one point I made the same argument you make. Now I don't see it that way. And I feel much better honestly

For what it's worth, I don't think it's ugly.

I think you're right that it's a personality thing, maybe connected to how strong the "rationalization drive" is? I don't know.

I guess I'd rather tickle the rationalizing side of my brain with a rationalizination of the tendency to stop rationalizing rather than just stop rationalizing :)

Re: When America first dropped acid

#109

I used to do psychedelics frequently and tried really hard to get something out of them. Up until the last time I dropped acid, I just got high and came down. The last time I ever did a psychedelic, I dropped acid and was reading this book called "Be Here Now" by Ram Dass. There's a part of the book that talks about drug induced psychosis. There's some illustration of lightning hitting a tower. I remember turning the…

>When I started doing them I wasn't able to believe in God, after that experience I could

meanwhile, the experience of general anesthesia basically took away my ability to believe in God

one in one out, I guess. It seems like I'd be happier if I'd gone the other way but one can't control what one believes

Re: When America first dropped acid

#110

Earlier quoted context omitted.

The effects of low doses of mushrooms/MDMA make me wonder if we have been going about it all wrong. You can easily take 20% of the normal amount and have a pleasant and noticeable effect but still be highly functional. It is like our "normal" dose for those drugs is the equivalent of 6+ drinks, and the idea of only having a beer or two is painted as a waste.

> The effects of low doses of _______ make me wonder if we have been going about it all wrong It's human nature to think that more is better. If a little works, why not use more. There's a definite bit of experimenting that should be done to see when more become less effective. As a user, that's just part of the journey. Then we have the marketing/sales view point where they just want those numbers higher, but it act…

melatonin is one where 1 mg works and 10 mg doesn't.
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