Using Technitium on your local network is like rolling your own Route 53 management console internally. I hate to use that comparison, but I think that'll hit more for some users on HN! If you need that kind of fine grained control, or if you just don't want your hand held on DNS, that is why you would choose this over PiHole.
Thank you to the Technitium team for giving us such a great product! Even if your name is hard to spell.