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Cells across the body talk to each other about aging

quantamagazine.org

171–173 of 173 posts

Re: Cells across the body talk to each other about aging

#171
post #169

Earlier quoted context omitted.

> There's no such thing as "no aging". Yeah there is: https://en.wikipedia.org/wiki/Negligible_senescence > To stop death is to enforce death. No. To stop absolutely all change is to enforce death. Aging is just one type of change amongst many that a person can experience. You may be unable to change in any way but aging, but me? I may mourn for the "meadow" that I saw being build when I was in infant school being tu…

Turtles age. I find it absurd I need to state the obvious. They age and die. They live longer because of their slow metabolism and... well they don't do much. You'll find it curious I did think about turtles when writing the comment you're responding to. Can you spot the part where I thought about turtles? Something about total productive life? You know, sitting idle for months on end and staring at one point is not…

> Can you spot the part where I thought about turtles?

The picture of a turtle at the of page, and that you stopped reading before the caption that says "some"?

That you definitely didn't look at any evidence linked to from it that directly contradicts your first claim?

And you definitely didn't read what is currently the last sentence of the first paragraph? Which reads:

"""Turtles, for example, were once thought to lack senescence, but more extensive observations have found evidence of decreasing fitness with age.[2]"""

Let alone the table further down? The one which says:

"""Maximum life span

Some examples of maximum observed life span of animals thought to be negligibly senescent are:

Rougheye rockfish 205 years[15][16]

Aldabra giant tortoise 255 years

Lobsters 100+ years (presumed)[17]

Hydras Observed to be biologically immortal[18]

Planaria Observed to be biologically immortal[19]

Sea anemones 60–80 years (generally)[20]

Red sea urchin 200 years[21]

Freshwater pearl mussel 210–250 years[22][23]

Ocean quahog clam 507 years[24]

Greenland shark 400 years[25]"""

(And just in case your eyes glazed over again: Aldabra giant tortoise: 255 years, even that list is not making the claim you're arguing against!)

Also note the distinction between negligible senescence and biological immortality.

> As I noted people who dream of immortality are either narcissists, or infantile, and I'm sorry to be blunt, but describing yourself as "a furry" strikes me as a combo of both.

- "3cats-in-a-coat" demonstrating how to throw stones in a glass house :P

Seriously though, this is all pattern matching to my earlier claim that your disgust prevented you from learning about the topic.

Your claim, which was why I chose to link to the negligible senescence page, was 'There's no such thing as "no aging"'; your claim is demonstrably false even if there's only one single example (https://en.wikipedia.org/wiki/Black_swan_theory etc.), so even mere hydras and planaria, simple as they are, ought to change your mind if you were not simply dismissing what you don't want to be true because you don't like it.

Re: Cells across the body talk to each other about aging

#172
post #60
post #52

Earlier quoted context omitted.

> survival of the species is not aligned with the survival of an individual The unit of survival is not the individual or the species, but the gene. Genes maximize their survival by combining via sexual reproduction with other genes over time. Any one combination of genes will be out-competed over time. The reason for honest aging signals is that a gene survives longer by getting out of the way of its offspring's com…

Why would women survive so long after menopause then ?

better curated memes

which are an expression of the concept of gene over the field of informatics, instead of the field of biology (unit cells vs unit bits)

Re: Cells across the body talk to each other about aging

#173

Aging should be classified as a disease because there has to be a set of biological levers that we can manipulate with drugs or other forms of medicine which will have an effect on the aging process across the entire. Like using RNA to reprogram the cells in the body to do things outside of what’s encoded in our base DNA. I don’t see why aging can’t be reversible, I’ve heard some people say it’s an impossible task be…

> But aging is just damage that accumulates over time, but damage can be repaired with the right tools. No, that's outdated. Another theory that aging is an intentional, programmed process is gaining more and more traction lately. Damage does accumulate over time, but it's not because the cells are incapable of repairing it, it's because they deliberately don't want to repair it . The developmental program that start…

Could you provide some articles / books on this please?
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