Did anyone inform doctor House about this? He will love this.
https://house.fandom.com/wiki/Lupus
Researchers trace a form of lupus back to a single mutation
21–27 of 27 posts
Re: Researchers trace a form of lupus back to a single mutation
#22I wonder if there's a viral trigger to some of these mutations, similar to the way EBV is implicated in the development of MS. It would also be interesting to do a longitudinal study in families that tend toward autoimmunity evaluating infant DNA to DNA later in life if they develop lupus to see when the mutuation occurs: is it present at birth or acquired?
I strongly suspect there absolutely is. Just look at the legions of patients suffering from long COVID (which btw, is still a thing even if you get vaccinated, though getting vaccinated significantly improves your chance of living and uh...not getting long COVID or sometimes even COVID to begin with), and compare the symptoms of those patients that had sepsis, septic shock, or were in the ICU for some reason. To see…
Also get vaccinated for influenza, tick bites... That is like a dozen shots every year, or once a month. Good luck with that.
Re: Researchers trace a form of lupus back to a single mutation
#23I always wondered about Lupus. An ex-boss of mine was insanely into health. Had a yoga studio for years and only ate the healthiest food. He got Lupis at 55. The other interesting thing is that his dad lived until he was 110.
A partner of mine was diagnosed with it when she was only 24 back in the mid 1990's. Back then it was often misdiagnosed, since symptoms overlapped with other illnesses, in her case rheumatoid arthritis. The first we knew if it was when she had a stroke.
Re: Researchers trace a form of lupus back to a single mutation
#24Earlier quoted context omitted.
Yeah...this sounds great but, maybe, like before declaring "Lupus Trigger Discovered", we should have a sample size of more than 1.
Critically it's more like "a" lupus trigger discovered. And there may be many.
We know there are many triggers. This is why they call lupus a polygenic Disorder. And it has as many variations of symptoms as it does causes. I mean there’s even drug induced lupus.
In my opinion, on the classification of disorders around symptoms does more harm than good when trying to discover the cause of the disorder.
We need to stop the delay in personalized medicine in order to cure people of these disorders. This is essentially what they did with this patient. They took the time and looked at their genetics, and they found what was wrong.
Re: Researchers trace a form of lupus back to a single mutation
#25I wonder if there's a viral trigger to some of these mutations, similar to the way EBV is implicated in the development of MS. It would also be interesting to do a longitudinal study in families that tend toward autoimmunity evaluating infant DNA to DNA later in life if they develop lupus to see when the mutuation occurs: is it present at birth or acquired?
In my opinion, from my own research, there will be many triggers to lupus. there is actually a lupus that caused by medication, called drug induced lupus. And lupus can be caused by more than autoimmunity. It can also caused by under immunity or immuno deficiency.
https://www.sciencedirect.com/science/article/pii/S225550211...
Re: Researchers trace a form of lupus back to a single mutation
#26The report says the cause was identified as a single letter change for the case of one individual patient. I was hoping to read if they tested other lupus sufferers to see if this change was the cause for more than the one patient they identified. Don't get me wrong -- I'm sure I'm they're investigating exactly that, but I was hoping the article had some news on that front.
Yeah...this sounds great but, maybe, like before declaring "Lupus Trigger Discovered", we should have a sample size of more than 1.
And once more the mods decided to change the title...They must be experts seconding the Max Plank foundation. I did it once, and was smoked to smithereens by the commenting here... :-)
Re: Researchers trace a form of lupus back to a single mutation
#27Food sensitivities to Nightshade vegetables include potatoes, tomatoes, peppers and several others can mimic the symptoms of both Lupus and Rheumatoid Arthritis in sensitive individuals.
When my late wife got those out of our diets, her symptoms of both Lupus and Rheumatoid Arthritis went away. This was after years of dealing with the Medical Establishment to treat the conditions with little results.