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The biggest losers: Metabolic damage or constrained energy?

physiqonomics.com

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Re: The biggest losers: Metabolic damage or constrained energy?

#11
post #8
post #7

OT, but is anyone else's HN homepage like, super stale? Most of the posts are from 12+ hours ago, some from more than a day. Edit: 5/30 less than 12 hours old, 16/30 more than 20 hours old.

I suppose they still have some issues, HN was down for a few hours today.

Ironically, I didn't notice that because MY internet was down, due to heavy winds/rain from the big storm yesterday.

Re: The biggest losers: Metabolic damage or constrained energy?

#12
post #6

> In 2016, Pontzer and colleagues published a study putting forward the constrained energy model: Energy expenditure does increase with more activity, but only to a point. Once physical activity gets really high, the body will adjust other components of the metabolism to keep your daily energy expenditure within a narrow range How do people who constantly repeat the mantra of thermodynamics in such threads explain th…

The only thing that makes sense to me is that the body gets more efficient.

Re: The biggest losers: Metabolic damage or constrained energy?

#13
In the last few months I read two books on this topic, and both (if I recalled correctly) mentioned The Biggest Loser (or similar).

Exercised - Daniel E Lieberman

https://www.npr.org/2021/01/05/953249677/exercised-explains-...

Burn - Herman Pontzer (who I believe was a student of Lieberman's)

https://www.scientificamerican.com/article/new-human-metabol...

Both a fairly dry and academic, but do get into the weeds if that's your thing.

A third book that's related but is an easier more entertaining read is "The Comfort Crisis" but Michael Easter.

https://eastermichael.com/book/

Easter actually interviews / quotes Lieberman.

The gist of all three...from an evolutionary perspective, the human body is designed for lean caloric times. When there is more calories than there is activity to burn it, those calories will be stored as fat (in preparation for leaner times). There's no ceiling on that so you'll keep adding weight.

In modern times, our evolutionary advantages become disadvantages. The best way to lose weight, is to not gain it in the first place.

Re: The biggest losers: Metabolic damage or constrained energy?

#14

But most contestants regained a lot of weight and metabolisms slowed relative to bodyweight and stayed slow long after regaining weight. The adaptation explains why they regained weight so fast. It's incontrovertible that the show was a failure for the majority of the contestants. this also agrees with the high failure rates of diets overall and why formerly fat people regain so fast . Biology screws you over and has…

I don’t understand how this needs anything beyond surface level complexity… you have fat people who for show reasons were tightly controlled on exercise and food intake - which works for well understood reasons - then they took that away and left the people to their lifelong established habits. Of course they regain the weight. These people didn’t magically create mass from nothing. They ate too much for their activi…

For those contestants, weight loss was a full time job, and they had trainers and dieticians. How is that supposed to work for average people who have jobs and families or do not have a lot of willpower? Weight loss drugs can make it easier, which I am all for. Availing oneself of medical technology is not cheating; it's why the technology exists in the first place.

Re: The biggest losers: Metabolic damage or constrained energy?

#15
post #7

OT, but is anyone else's HN homepage like, super stale? Most of the posts are from 12+ hours ago, some from more than a day. Edit: 5/30 less than 12 hours old, 16/30 more than 20 hours old.

It looks to me like HN has been in a massive censorship mode in order to remove ongoing stories about the Bitcoin ETF, the SEC and the Twitter/X hack of the SEC's account.

That story was on the top by far yesterday and then it suspiciously disappeared, after the comments took a very decidedly (and very deservingly, in my opinion) anti-Muskian bent.

Since then there has been no story about the bitcoin ETF on the front page of HN even though it is a very important time for bitcoin (the deadline for bitcoin etf inclusion is today) and HN loves talking about bitcoin.

So there is your answer.

Re: The biggest losers: Metabolic damage or constrained energy?

#16
post #12
post #6

> In 2016, Pontzer and colleagues published a study putting forward the constrained energy model: Energy expenditure does increase with more activity, but only to a point. Once physical activity gets really high, the body will adjust other components of the metabolism to keep your daily energy expenditure within a narrow range How do people who constantly repeat the mantra of thermodynamics in such threads explain th…

The only thing that makes sense to me is that the body gets more efficient.

That what I imagined as I was reading, the act of breathing and pushing blood around the body just becomes easier when you are fit. (requires less energy)

Re: The biggest losers: Metabolic damage or constrained energy?

#17

But most contestants regained a lot of weight and metabolisms slowed relative to bodyweight and stayed slow long after regaining weight. The adaptation explains why they regained weight so fast. It's incontrovertible that the show was a failure for the majority of the contestants. this also agrees with the high failure rates of diets overall and why formerly fat people regain so fast . Biology screws you over and has…

I don’t understand how this needs anything beyond surface level complexity… you have fat people who for show reasons were tightly controlled on exercise and food intake - which works for well understood reasons - then they took that away and left the people to their lifelong established habits. Of course they regain the weight. These people didn’t magically create mass from nothing. They ate too much for their activi…

Sure, blame the people. Fat shame all you want. Problem solved. Done.

It's so easy, just stop eating so much. As if fat people haven't heard that one a bilion times over. As if fat people havent tried time and time again.

Personal responsibility! you put that stuff in your mouth, rah! rah!

Personally I'm actually sick of people having no eye for the bigger picture, for many systemic reasons and larger society, and just blame stuff like this on individuals.

Re: The biggest losers: Metabolic damage or constrained energy?

#18

But most contestants regained a lot of weight and metabolisms slowed relative to bodyweight and stayed slow long after regaining weight. The adaptation explains why they regained weight so fast. It's incontrovertible that the show was a failure for the majority of the contestants. this also agrees with the high failure rates of diets overall and why formerly fat people regain so fast . Biology screws you over and has…

I don’t understand how this needs anything beyond surface level complexity… you have fat people who for show reasons were tightly controlled on exercise and food intake - which works for well understood reasons - then they took that away and left the people to their lifelong established habits. Of course they regain the weight. These people didn’t magically create mass from nothing. They ate too much for their activi…

It requires that complexity because a metric shit ton of scientific research shows that it is more complicated than that.

Permanent weight loss of more than ten pounds is nearly impossible from a scientific standpoint. The success rate after 5 years of weight loss is somewhere around 0.1%. You'd think that if it was as easy as everyone claims, more people would succeed. Heck, many people who have had gastric bypass surgery regain a significant amount of weight, even if their stomachs have been reduced to the size of a ping pong ball.

Re: The biggest losers: Metabolic damage or constrained energy?

#20

But most contestants regained a lot of weight and metabolisms slowed relative to bodyweight and stayed slow long after regaining weight. The adaptation explains why they regained weight so fast. It's incontrovertible that the show was a failure for the majority of the contestants. this also agrees with the high failure rates of diets overall and why formerly fat people regain so fast . Biology screws you over and has…

FYI the show was not an incontrovertible failure for most contestants

> Six years after the competition, median weight loss in 14 of "The Biggest Loser" participants was 13%...

That means at least 7 of them lost 13%. That's pretty significant. On Ozempic, average weight loss is 11% after six months.

The show worked for the majority, and the difference between the people who it worked for and the people for whom it did not work is Physical Activity not Energy Intake. This is covered in the OP link and also in https://pubmed.ncbi.nlm.nih.gov/29086499/

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