Earlier quoted context omitted.
Pypy actually works really well. It could probably get even farther if people knew about it more. Test your packages on Pypy, people.
The only trouble is C packages, which are really really common, right? So you have a performance hit or something (or so I heard) I guess that now the GIL is going away, pypy will become better at handling packages with native code like numpy
Most c extension modules should work in pypy, there's just a performance hit depending on how they're built (cffi is the most compatible).
https://doc.pypy.org/en/latest/faq.html#do-c-extension-modul...