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Blueprint health protocol

protocol.bryanjohnson.com

161–170 of 202 posts

Re: Blueprint health protocol

#163
post #127

I know I’m going to get downvoted for going against the crowd, but as a biochemist my impression here is that there’s at least as much pseudoscience as there is science.

As someone training more in CS/stats, without formal bio training, can you point out the main items of pseudoscience?

Seems like he's doing the classic "management" tactic of setting targets, measuring progress, and coming up with models to best represent/simplify complex systems.

Re: Blueprint health protocol

#165
post #127

I know I’m going to get downvoted for going against the crowd, but as a biochemist my impression here is that there’s at least as much pseudoscience as there is science.

Any specific things you can call out?

Re: Blueprint health protocol

#166

Earlier quoted context omitted.

Wouldn't that make these illnesses incurable? Not sure what makes alzheimers an illness and wrinkly skin not an illness.

The article is about trying to cure aging. That includes both Alzheimer's and wrinkly skin.

Article is about slowing the rate of aging not 'cure aging' .

Re: Blueprint health protocol

#167

I love what the guy is doing. It is a one-man experiment that would be very very hard to reproduce, or even get ethics approval and funding for, by a research lab. But on the other hand, I get a sense that the public side of his results are overblown. For example, my field is epigenetics, so I had a look at his "epigenetic clock" results. He uses "DunedinPACE" to track the rate of aging and his result is supposedly 0…

This guy spent so much trying not to die that he’s not living at all.

Re: Blueprint health protocol

#168

Earlier quoted context omitted.

He stays out of the sun? Interesting to learn what the long term consequences of that will be.

My bet is this will be reversed at some point. I get that the metric dictating this is probably "avoid skin damage", but surely the health benefits of, say, 15 minutes of sun exposure dramatically overweighs the risk of skin cancer.

There's a suggestion that the senescent effects of skin aging have a systemic effect. Anti senescents or senescent modulators might counter such an effect and allow the positive benefits of sun with fewer negatives.

Re: Blueprint health protocol

#169
post #57

Earlier quoted context omitted.

Why so? A vegan diet when supplemented is an easy way to avoid potential bad consequences of animal products, such as heart disease, cancer, obesity or diabetes. The only real thing that meat-eaters do not have to supplement that vegans do is b12 (because livestock are supplemented with it) and maybe omega 3.

40% of the population is B12 deficient: https://eatingourfuture.wordpress.com/science-studies-vegan-... So most people should supplement, not just vegans.

This directly contradicts the Wikipedia article on the subject [1], and in general the page you link looks more like pseudoscience than not. Do you have a better source, maybe from a published paper or the NIH?

1: https://en.m.wikipedia.org/wiki/Vitamin_B12_deficiency

Re: Blueprint health protocol

#170

I love what the guy is doing. It is a one-man experiment that would be very very hard to reproduce, or even get ethics approval and funding for, by a research lab. But on the other hand, I get a sense that the public side of his results are overblown. For example, my field is epigenetics, so I had a look at his "epigenetic clock" results. He uses "DunedinPACE" to track the rate of aging and his result is supposedly 0…

> Why not mention things like that along with all the optimism? The only people I see with extreme optimism are weird tech people. Most people I follow outside of that circle range from laughing at this to "kinda neat" (like you and me). Is anyone convinced this is "worth it", or that what he's doing is actually anti-aging anything?

The following protocol will put most people in the top 20% of health outcomes if you're consistent for 2 years. If you're baseline healthy, it'll put you in top 10%. If you keep it up for a lifetime, I'm certain it will add at least a decade of 'high quality years' to your life (I'm not talking life extension, but quality of life).

A good diet (no/minimal processed foods), lots of water, 7.5-8 hours of sleep, limited stress, strong family/social circle, regular (3-5x per week) cardio, (2x per week) strength training, 1x per week high intensity cardio for 30 minutes, and regular stretching/flexibility for 15 minutes per day.

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