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Moderna's mRNA cancer vaccine works better than thought

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Re: Moderna's mRNA cancer vaccine works better than thought

#131

Post by lern_too_spel »

guraf wrote: post #93
gumballindie wrote: post #62

Earlier quoted context omitted.

People monitored via 5g by the angry agi goddess. Truly, this flat earth of our’s is magnificent. Thanks for reminding me of that.

Ridiculing people who are worried about long term effects of something that has been in use for only a few years is such an HN thing. There's countless precedent for things once touted as being safe to turn out incredibly damaging. We just don't know the long term effect yet. Please spare me with the "but there's no mechanism for it to do harm!!!!!" the same was said for all the other drugs that ended up causing canc…

The vaccines that people are getting ridiculed about have been administered to more than 5 billion people. If there were any such extremely damaging long term effects, we would have seen some already.

Re: Moderna's mRNA cancer vaccine works better than thought

#133

Post by blackbear_ »

loceng wrote: post #65
kurthr wrote: post #52

Earlier quoted context omitted.

In particular: The vaccine works by instructing the body to make up to 34 “neoantigens.” These are proteins found only on the cancer cells, and Moderna personalizes the vaccine for each recipient so that it carries instructions for the neoantigens on their cancer cells.

And let me guess - there's a massive lobbying effort to be able to patent each of these neoantigens, if they're not already getting patents approved for them? Edit: Ah yes, why patent specifics when you can patent the umbrella which is akin to covering all bases - https://patents.google.com/patent/US10055540B2/en

Very unlikely, as the majority of those neoantigens are unique to the patient (that's why the vaccine has to be tailored for each of them).

Re: Moderna's mRNA cancer vaccine works better than thought

#134

Post by loceng »

blackbear_ wrote: post #133
loceng wrote: post #65

Earlier quoted context omitted.

And let me guess - there's a massive lobbying effort to be able to patent each of these neoantigens, if they're not already getting patents approved for them? Edit: Ah yes, why patent specifics when you can patent the umbrella which is akin to covering all bases - https://patents.google.com/patent/US10055540B2/en

Very unlikely, as the majority of those neoantigens are unique to the patient (that's why the vaccine has to be tailored for each of them).

Ah yes, why patent specifics when you can patent the umbrella which is akin to covering all bases - https://patents.google.com/patent/US10055540B2/en

Re: Moderna's mRNA cancer vaccine works better than thought

#135

Post by [deleted] »

chiefalchemist wrote: post #108
lumb63 wrote: post #84

Earlier quoted context omitted.

All previous vaccines were aimed at preventing infectious diseases. None of them are (primarily) indicated for preventing recurrence of a non-infectious disease. Whether it meets the technical definition or not, we can probably agree this is fundamentally different to all other vaccines. Also, since no other vaccines are custom to each patient, using the term “vaccine” could cause confusion. Do we really want to give…

The idea that marketed vaccines are safe & effective has been well marketed and deeply planted in the minds of the public. It's easier to leverage that familiarity than it is to build awareness and trust for "immunotherapy".

[deleted]

Re: Moderna's mRNA cancer vaccine works better than thought

#136

Post by blackbear_ »

oldgradstudent wrote: post #96
bawolff wrote: post #13

Earlier quoted context omitted.

I mean, it seemed like it worked pretty well with covid. Vaccine was produced very quickly, and in most countries was free.

It was a bit expensive, and it took some time to ramp up production. Still impressive, though. The problem was that almost everyone who got the vaccine also caught the disease.

Vaccines are not intended to prevent people from getting the disease. Their purpose is to make the body defeat the disease faster while taking less damage.

Re: Moderna's mRNA cancer vaccine works better than thought

#137

Post by OrvalWintermute »

azan_ wrote: post #28
neverrroot wrote: post #10

Earlier quoted context omitted.

[flagged]

mRNA will eventually save the day for everyone, including for perfectly healthy individuals, but to me as a healthy 40yo person, with no known immunity issues, not overweight etc. etc. it is in my opinion still too risky to take just like that. It's an interesting take. From what we know so far, the risk from taking vaccine is much smaller than from covid infection. You might counter this with highlighting the "so fa…

I'll tell that to my colleague that got Covid vaccine induced blood clots, and has been told he will be on blood thinners for life.

While this is anecdotal, the amount of people I know personally that have told me they had significant health issues with a Covid vaccine or covid booster is weird.

Re: Moderna's mRNA cancer vaccine works better than thought

#138

Post by throwaway29812 »

Terr_ wrote: post #115
JumpCrisscross wrote: post #25

Earlier quoted context omitted.

> bar for side effects is much stricter for preventative treatments like vaccines These vaccines are for treatment. They don’t prevent cancer. They treat it. They’re vaccines because they work by arming your immune system versus doing the fighting themselves.

A comparison with rabies vaccine may be useful here. On the scope of the entire human body, the virus usually enters first, before the vaccine is used. However on the scope of individual tissues and cells, the vaccine is often the first on the scene, prepping your cells before the (sneaky, slow) virus makes its main attack.

All of this is completely based on the individual case.

Re: Moderna's mRNA cancer vaccine works better than thought

#139

Post by lawlessone »

oezi wrote: post #109
cscurmudgeon wrote: post #76

Earlier quoted context omitted.

> The size of the pages side effects were written on says absolutely nothing about what the side effects are or their severity. Naive question: Do they say what the side effects are and their severity in an easily accessible manner somewhere?

From the sibling comment link I would say, yes: 5 WARNINGS AND PRECAUTIONS 5.1 Management of Acute Allergic Reactions Appropriate medical treatment to manage immediate allergic reactions must be immediately available in the event an acute anaphylactic reaction occurs following administration of Moderna COVID-19 Vaccine. Monitor Moderna COVID-19 Vaccine recipients for the occurrence of immediate adverse reactions acco…

Those last two points are why it is was the right thing to do for ostensibly healthy people to get vaccinated.

Because there are people we know it doesn't work for and people we don't know it doesn't work for.

Re: Moderna's mRNA cancer vaccine works better than thought

#140

Post by throwaway29812 »

OrvalWintermute wrote: post #137
azan_ wrote: post #28

Earlier quoted context omitted.

mRNA will eventually save the day for everyone, including for perfectly healthy individuals, but to me as a healthy 40yo person, with no known immunity issues, not overweight etc. etc. it is in my opinion still too risky to take just like that. It's an interesting take. From what we know so far, the risk from taking vaccine is much smaller than from covid infection. You might counter this with highlighting the "so fa…

I'll tell that to my colleague that got Covid vaccine induced blood clots, and has been told he will be on blood thinners for life. While this is anecdotal, the amount of people I know personally that have told me they had significant health issues with a Covid vaccine or covid booster is weird.

Blood clotting in COVID is higher than instances of Vaccine induced clotting, in every measure. For every example like your colleague, there are many more for COVID itself.
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