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Moderna's mRNA cancer vaccine works better than thought
111–120 of 258 posts
Re: Moderna's mRNA cancer vaccine works better than thought
#112Past mRNA cancer vaccines haven't failed to get through trials because of ineffectiveness. They failed clinical trials in the 2000s and 2010s due to their side effects being too bad. The side effects of mRNA vaccines are getting less and less severe over the years, but the proof of the pudding will come in phase III for this vaccine, as with all the other ones.
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Re: Moderna's mRNA cancer vaccine works better than thought
#113Earlier quoted context omitted.
mRNA will eventually save the day for everyone, including for perfectly healthy individuals, but to me as a healthy 40yo person, with no known immunity issues, not overweight etc. etc. it is in my opinion still too risky to take just like that. It's an interesting take. From what we know so far, the risk from taking vaccine is much smaller than from covid infection. You might counter this with highlighting the "so fa…
>the risk from taking vaccine is much smaller than from covid infection Does that matter if you get covid anyway?
Yes. The vaccine trains your immune system to create antibodies used to fight off the disease. Already having those antibodies when the virus appears means that it will not last as long and the symptoms will not be as severe.
Without the vaccine, your body has to create those antibodies while you are already sick, and that takes time. This gives the virus a huge head start.
Re: Moderna's mRNA cancer vaccine works better than thought
#114[flagged]
Re: Moderna's mRNA cancer vaccine works better than thought
#115Earlier quoted context omitted.
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> bar for side effects is much stricter for preventative treatments like vaccines These vaccines are for treatment. They don’t prevent cancer. They treat it. They’re vaccines because they work by arming your immune system versus doing the fighting themselves.
A comparison with rabies vaccine may be useful here.
On the scope of the entire human body, the virus usually enters first, before the vaccine is used.
However on the scope of individual tissues and cells, the vaccine is often the first on the scene, prepping your cells before the (sneaky, slow) virus makes its main attack.
Re: Moderna's mRNA cancer vaccine works better than thought
#116Should this really be called a “vaccine”? I feel like that is going to give people the wrong impression about what it does. I think labelling it gene therapy, immune therapy, or something like that would be closer to what it actually does. Also really interested to see if people will need and/or benefit from periodic re-treatment. I guess they can figure that part out if it makes it to market.
It is definitely not a gene therapy.
Re: Moderna's mRNA cancer vaccine works better than thought
#117Earlier quoted context omitted.
>You should do the healthy things to avoid cancer in the first place What are those?
There's a certain set of healthy recommendations, but to clarify none of them will absolve the risk completely.
>There's a certain set of healthy recommendations
But they are all very general and very vague. Eat right. Exercise. Avoiding smoking and alcohol, unless it's red wine. Be wealthy Drink Coffee.
Sorry just when I see people suggesting healthy lifestyle under this and other articles for things like heart disease mRNA treatments, it generally betrays that they view being sick as a personal failing.
1 in 2 people will contract cancer according to the NHS. https://www.nhs.uk/conditions/cancer/
The biggest factor with cancer is age. https://www.cancerresearchuk.org/health-professional/cancer-...
Re: Moderna's mRNA cancer vaccine works better than thought
#118Earlier quoted context omitted.
> but the ones for the CV vaccine were listed on many pages of tiny text (both from Pfizer and from Moderna). A whole bunch of OTC drugs carry CYA lists like this, it's not the gotcha you think it is. > but to me as a healthy 40yo person, with no known immunity issues, not overweight etc. My father is getting a stent put in for a 70% artery blockage. Older of course but skinny, looks after his health, exercises. He h…
Yeah you gotta love the people like “COVID is only super dangerous if you have comorbidities!” Yeah dude have you ever walked around and looked at people? Then have you ever talked even to people who outwardly appear healthy? Comorbidities run amok, known and unknown.
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Re: Moderna's mRNA cancer vaccine works better than thought
#119Earlier quoted context omitted.
People monitored via 5g by the angry agi goddess. Truly, this flat earth of our’s is magnificent. Thanks for reminding me of that.
Ridiculing people who are worried about long term effects of something that has been in use for only a few years is such an HN thing. There's countless precedent for things once touted as being safe to turn out incredibly damaging. We just don't know the long term effect yet. Please spare me with the "but there's no mechanism for it to do harm!!!!!" the same was said for all the other drugs that ended up causing canc…
That is true. But I wish there was more evidence presented for it. Crying wolf does more harm than good.
Re: Moderna's mRNA cancer vaccine works better than thought
#120Earlier quoted context omitted.
It is intended for people who’ve had high-risk melanomas removed, to prevent cancer from coming back.
The reason preventative treatments are held to a higher standard is because they are given to a very large number of people who might never get the disease anyway. Hence, a 1 in 1000 risk is significant. If you are treating people who have had cancer, their risk of getting it again in much higher than 1 in 1000.
Right. There's also the fact that the FDA will accept much worse side effects for a cancer treatment than they would for (e.g.) an athlete's foot treatment.
For a bad cancer like some melanomas, just about anything that doesn't kill the patient outright is gonna be on the table.