101–110 of 158 posts
So, in order to bypass the FDA, you plan to produce a bacterium, export it, go somewhere outside the US, pass it to people and then everybody returns to the US? what happens if someone, ahem, takes a dim view of the process and denies entry on biosecurity grounds?
People aren't tested for any contagious illnesses when entering the country.
> The FDA demanded a study of 100 subjects, all of whom had to be “age 18-30, with removable dentures, living alone and far from school zones”. Hillman wasn’t sure there even were 100 young people with dentures, but the FDA wouldn’t budge from requiring this impossible trial. Hillman gave up and switched to other projects Interesting that the FDA can request such things. Would be a good way to block disruptive produc…
Earlier quoted context omitted.
funny how one "the" flips the meaning of the sentence I thought I was being paranoid until I started reading the article I choose to believe this is a freudian slip, which means they're trying to cause tooth decay while pretending to do the opposite. If I were dentistry as a business, I wouldn't like this permanent (final) solution to tooth decay because of my unreasonably suspicions that the odontological treatment…
Rise up sheeple, and rinse out your mouth with bleach twice daily to remove any gentech germs! Big Teeth and their engineered bacteria are keeping us down!
Earlier quoted context omitted.
I should clarify: there’s some more details to why S mutans actually requires low pH. The correct term wouldn’t be “tolerate low pH” but rather “requires low pH” for its stable colonization. S mutans creates incipient lesions by making acid, incipient lesions are micro environments where the low pH that causes enamel decay is determined by the biofilm on its surface. S mutans cannot thrive in environments with neutra…
The article gives this as the explanation of how it is supposed to work: BCS3-LI has four main genetic modifications: It produces a weak antibiotic, mutacin-1140, which kills competing oral bacteria. It’s immune to mutacin-1140, so it doesn’t kill itself. It metabolizes sugar through a different chemical pathway that ends in alcohol instead of lactic acid. It lacks a peptide that its species usually uses to arrange g…
It'd be quite funny to live in a future where cavities don't exist, but breathalysers are useless. (without rinsing your mouth out first, I guess) Hopefully it doesn't dry out gums and cause gum disease.
Is there a way to determine if FDA actually set this requirement for the study? Is it on public record? Or do we just have to rely on what they claim. Also why not try getting it approved elsewhere first like in the EU if FDA is making it harder to approve?
Earlier quoted context omitted.
Rise up sheeple, and rinse out your mouth with bleach twice daily to remove any gentech germs! Big Teeth and their engineered bacteria are keeping us down!
Teeth are an abomination and your body works hard to reject them, purifying your mouth and your soul so you can die appropriately shriven of your sin. Big Dentistry is trying to keep you from heaven!
This story has been around for far too long and evidence is unbelievably weak, and the claims border on fraudulent. 1. The claim that this strain outcompetes the same S mutans from occupying the same niche cannot be true unless this strain is also capable of creating and tolerating environments with low pH. By definition if it creates acid to the same degree it will also cause cavities. 2. Single applications are ins…
https://probiorahealth.com/product/probiora/
A decade or so ago, their founder started with genetically modified bacteria that supposedly outcompete wildtype strains. The regulators responded in the only sane way possible, and it didn't go to human trials, from what I can tell.
List of publications from their founder:
https://pubmed.ncbi.nlm.nih.gov/?term=Hillman+JD&cauthor_id=...
Later, they just cultured a large number of wild strains, looking for ones with the desired properties, and now sell a mixture of three of them.
(Edit: I just realized the company in the article is selling the old work from Hillman's lab, but he is not a member of the team. I'm guessing you don't have a high opinion of this follow on work either then?)
So, in order to bypass the FDA, you plan to produce a bacterium, export it, go somewhere outside the US, pass it to people and then everybody returns to the US? what happens if someone, ahem, takes a dim view of the process and denies entry on biosecurity grounds?
People aren't tested for any contagious illnesses when entering the country.