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A genetically modified bacterium that outcompetes bacteria causing tooth decay

astralcodexten.com

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Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#91
post #75
post #74

Earlier quoted context omitted.

Scott absolutely analyses topics in bad faith, particularly when it comes to politics or movements/people he personally supports. Here's one where he essentially says 'no study is ever fully representative, therefore my friends twitter polls are exactly as good evidence as a scientific study': https://www.astralcodexten.com/p/selection-bias-is-a-fact-of...

Your comment is an example of analyzing in bad faith. In the linked article there is a whole section that starts with "Selection bias is disastrous if". He definitely does not says anything remotely close to "twitter polls are exactly as good evidence as a scientific study".

It's essentially the thesis of the post. I will say the "exactly" part was a bit hyperbolic.

He starts by stating that people say his surveys and Aella's Twitter polls (which he calls surveys) have selection bias, meaning the conclusions don't count.

He then goes on to say (paraphrasing): "people say surveys have selection bias, but don't think real scientific studies have selection bias" and in the next paragraph says "but scientific studies do have selection bias and that's ok." Note that in this section, he is implictly relating scientific studies with his and aellas surveys.

In the section that starts with "selection bias is disasterous if", he gives a narrow view of why and when it's bad: "only if you're doing a poll or census that should include everyone". He neglects to say the ways in which it's bad for literally all science (it's a massive problem in drug RCTs, but he literally uses RCTs as a point for why selection bias isn't so bad later on).

In the next few paragraphs he says that selection bias is fine for correlations, and gives some examples of when scientific studies have selection bias that we accept (I'm not going into details here because the post is long, and I'm on my phone).

So he's said why selection bias is present in science, and that it's only really bad for census's and polls. He then concludes, "hey guys stop saying surveys are bad because selection bias, science is also biased".

In this post he starts by bringing up a critism of Aella's 'research', which she uses data from Twitter polls for. He then implicitly equates surveys and scientific studies, and says "look, science is biased too, so selection bias isn't bad". He then concludes, "so stop saying surveys are a bad because of selection bias".

He might not literally say "twitter polls are exactly as good evidence as a scientific study", but the point of the post was to detract from the valid criticisms against his and Aella's posts that use survey/twitter poll data by saying "science does it too".

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#92
post #33

> They offered my wife and me free samples (based on her work, not as compensation for writing this post); she accepted, and I’m still debating. Given that it's an oral colonist it seems likely that the author has tried the free sample as well, even if they were to live in a no-kissing houshold. The title is a lovely garden path sentence: "A genetically modified bacterium that outcompetes bacteria causing tooth decay…

funny how one "the" flips the meaning of the sentence

I thought I was being paranoid until I started reading the article

I choose to believe this is a freudian slip, which means they're trying to cause tooth decay while pretending to do the opposite.

If I were dentistry as a business, I wouldn't like this permanent (final) solution to tooth decay because of my unreasonably suspicions that the odontological treatment I received as a child was unconsciously intended to make me continue to need 'dental care' instead of fixing anything. Last time I was at a (very expensive private) dental clinic the treatment they pushed on to me was killing my tooth so I would buy one. I'm pretty sure some hugely powerful branch of dentistry is betting on people in my demographic (who get their teeth killed off) buying a full set of teeth from them in the future.

But I would only accept Thompson teeth, the only teeth capable of chewing other teeth

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#93
post #29

Earlier quoted context omitted.

The idea that primates get cavities less frequently than modern humans is a bit outdated and not terribly supported by recent studies. The main difference is in the location of the cavities, not frequency – apes tend to get cavities in their front teeth, humans tend to get cavities in the molars.

Oh interesting. I didn't realize. Are there theories on what causes that difference? Is it diet?

[deleted]

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#94
post #33

> They offered my wife and me free samples (based on her work, not as compensation for writing this post); she accepted, and I’m still debating. Given that it's an oral colonist it seems likely that the author has tried the free sample as well, even if they were to live in a no-kissing houshold. The title is a lovely garden path sentence: "A genetically modified bacterium that outcompetes bacteria causing tooth decay…

funny how one "the" flips the meaning of the sentence I thought I was being paranoid until I started reading the article I choose to believe this is a freudian slip, which means they're trying to cause tooth decay while pretending to do the opposite. If I were dentistry as a business, I wouldn't like this permanent (final) solution to tooth decay because of my unreasonably suspicions that the odontological treatment…

Rise up sheeple, and rinse out your mouth with bleach twice daily to remove any gentech germs! Big Teeth and their engineered bacteria are keeping us down!

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#95
The idea that they've engineered a bacterium that will successfully outcompete naturally selection indefinitely seems overly optimistic. They blocked the most obvious failure mode with the horizontal gene transfer pathway, sure, but considering how quickly antibiotics become ineffective I'm just not sold that their modified bacteria will be as untouchable as they seem to think. Certainly not 20 grand effective.

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#96
post #12

Earlier quoted context omitted.

I trust the sceince just fine, i dont trust corporate interests and how heavily and deeply coporate rot has penetrated into our institutions. I activly expect dishonesty on the part of corporate interest, and corporate interest is increasingly if not already entierly, government interest.

Do you have any examples of how the FDA is starting to put corporate interest ahead of public interest?

FDA Warning Letters: your pharmaceutical manufacturing plant was found to have adulteration and QA issues (again). Your medication actually has other medications or precursor/intermediate chemicals in it (again). FDA's response: a wag of the finger (again). So you "fix" the issue the next time the FDA Boy Scout comes around. All set.

Rinse and repeat.

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#97

Earlier quoted context omitted.

funny how one "the" flips the meaning of the sentence I thought I was being paranoid until I started reading the article I choose to believe this is a freudian slip, which means they're trying to cause tooth decay while pretending to do the opposite. If I were dentistry as a business, I wouldn't like this permanent (final) solution to tooth decay because of my unreasonably suspicions that the odontological treatment…

Rise up sheeple, and rinse out your mouth with bleach twice daily to remove any gentech germs! Big Teeth and their engineered bacteria are keeping us down!

[deleted]

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#98

I've just started using ProBiora3 to try to reduce my gingivitis levels. I would love a one-application solution and will be watching this closely.

I use lactibiane buccodental pills, it's the only one I could find in my local pharmacies. I also regularly use curaprox moutwash with chlorhexidine.

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#99
post #66

Earlier quoted context omitted.

Diet doesn't do much if you have bad genetics, I eat and brush the same as my gf, we don't smoke/drink, exercise the same, we basically have the same exact lifestyle. She has teeth issues multiple times a year, I never had a single problem

Are you sure ? My girlfriend says one thing but I observe the daily unaccounted for consumption of fruit and sweets. Fair enough if you also consume lots of sweets, though.

100% sure, first because I trust her and second because there is no way I wouldn't notice given our current work/life situation

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#100
It's insane to voluntarily colonize your body with a virtually untested genetically engineered bacteria. The article claims it occurs naturally but they have no good data on its natural prevalence and they added two additional mutations to the natural strain they found.

Even if it's safe, is it effective? The only way to tell is to enroll the people who are colonized in a long-running study. Are they doing that?

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