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A genetically modified bacterium that outcompetes bacteria causing tooth decay

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Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#51

I've just started using ProBiora3 to try to reduce my gingivitis levels. I would love a one-application solution and will be watching this closely.

Have you tried just using interdental brushes, like these[1]? Using these once a day did wonders for my gingivitis levels.

[1] https://www.amazon.com/Sunstar-6505A-Soft-Picks-Advanced-Pac...

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#54
This specific product aside, it seems to me there could be huge future potential in therapies involving genetically engineered bacteria. We can modify bacteria far more easily than we can our own genomes. And we're just beginning to develop an understanding of the gut microbiome. As that understanding improves, surely there will be opportunities to make beneficial changes.

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#55

Anecdote time: My great grandmother lived to be 102 and never had a cavity. Kept all her teeth to the end. One time, an orderly who thought she was just being senile tried to reach into her mouth to take out her teeth (thinking she had dentures). My great grandmother bit that person; hope they learned not all old people are senile! I’m 40% of the way there. No cavities and rave reviews from my dentist. I brush—-best…

You should start a company providing kissing therapies

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#56
I just rinse my mouth every night with sugar, in addition to brushing. Have not had problems since. Effect of three-year consumption of erythritol, xylitol and sorbitol candies on various plaque and salivary caries-related variables https://pubmed.ncbi.nlm.nih.gov/24095985/

Xylitol and erythritol inhibit real-time biofilm formation of Streptococcus mutans https://pubmed.ncbi.nlm.nih.gov/32600259/

And, what I always expected, it is better to rinse with two sugars:

Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries https://pubmed.ncbi.nlm.nih.gov/32286378/

two tablespoons and 50 ml of handwarm water (the stuff does not really dissolve good), a few drops of this: https://www.apodiscounter.de/myrrhentinktur-hetterich-30ml-p...

This tincture might not be available in the US due to alcohol content. I saw only oil based versions in the US.

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#57

I use a similar product, LEF Florassist Oral https://www.lifeextension.com/vitamins-supplements/item02120... That has BLIS M18™ and Immuno-LP20® BLIS M18: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012604/ I have not noticed any difference.

Does this help with morning breath?

No :(

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#58

I just rinse my mouth every night with sugar, in addition to brushing. Have not had problems since. Effect of three-year consumption of erythritol, xylitol and sorbitol candies on various plaque and salivary caries-related variables https://pubmed.ncbi.nlm.nih.gov/24095985/ Xylitol and erythritol inhibit real-time biofilm formation of Streptococcus mutans https://pubmed.ncbi.nlm.nih.gov/32600259/ And, what I always e…

Sugar alcohols*. You certainly should not rinse your mouse with sucrose as your first sentence implies would be fine.

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#59
post #49

Anecdote time: My great grandmother lived to be 102 and never had a cavity. Kept all her teeth to the end. One time, an orderly who thought she was just being senile tried to reach into her mouth to take out her teeth (thinking she had dentures). My great grandmother bit that person; hope they learned not all old people are senile! I’m 40% of the way there. No cavities and rave reviews from my dentist. I brush—-best…

What is your diet ? I am assuminf there is no processed sugar or refined wheat/gluten ?

Not OP, but in a similar situation. I'm 39, the last time a dentist looked in my mouth I was probably 16 or so* and I brush only once a day (after breakfast, which is the least effective over doing it before going to sleep). Never had a cavity. I don't think I have halitosis, at least the people I have kissed over the years never complained to me.

Being Italian, I eat pasta literally every day, and my daily breakfast is chocolate chip cookies.

My impression is that mouth health is 100% genetics and biome lottery.

* I have extreme mistrust in their profession, due to bad experiences. When I was a kid, I injured a milk tooth which turned black. The dentist shrugged and said that it would fall normally. It didn't and it fucked up all permanent teeth that sprouted in random directions in the area. Every single dentist surveyed to fix the problem requested gigantic payments (to the tune of tens thousands of dollars, this was in the 90s in Italy, so adjust for inflation and cost of living to know how crazy this was) without providing any result guarantees, so I kept my crooked teeth. It doesn't help dentistry in Italy is that profession where you mainly do tax evasion, and occasionally look into people mouths to pass the time.

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#60

I just rinse my mouth every night with sugar, in addition to brushing. Have not had problems since. Effect of three-year consumption of erythritol, xylitol and sorbitol candies on various plaque and salivary caries-related variables https://pubmed.ncbi.nlm.nih.gov/24095985/ Xylitol and erythritol inhibit real-time biofilm formation of Streptococcus mutans https://pubmed.ncbi.nlm.nih.gov/32600259/ And, what I always e…

I rinse my mouth regularly with coffee and chocolate containing sugar. I always thought it was a bad thing. Bring on the donuts!
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