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A genetically modified bacterium that outcompetes bacteria causing tooth decay

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11–20 of 158 posts

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#11

I've just started using ProBiora3 to try to reduce my gingivitis levels. I would love a one-application solution and will be watching this closely.

I used this one for a little while and I regret it. I'm pretty sure it messed up my mouth microbiome -- been having worse breath, more deposits on teeth/tooth pain, and a lot of gum bleeding. All once I stopped taking it.

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#12

Earlier quoted context omitted.

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I trust the sceince just fine, i dont trust corporate interests and how heavily and deeply coporate rot has penetrated into our institutions. I activly expect dishonesty on the part of corporate interest, and corporate interest is increasingly if not already entierly, government interest.

Do you have any examples of how the FDA is starting to put corporate interest ahead of public interest?

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#13

Earlier quoted context omitted.

[flagged]

I trust the sceince just fine, i dont trust corporate interests and how heavily and deeply coporate rot has penetrated into our institutions. I activly expect dishonesty on the part of corporate interest, and corporate interest is increasingly if not already entierly, government interest.

Same here. I also think it’s “we the people’s” fault to a large degree as well. These institutions require citizens to elect leaders who will put them in check. We don’t do that. The system largely works so people don’t really care that much, myself included.

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#14

Earlier quoted context omitted.

[flagged]

I trust the sceince just fine, i dont trust corporate interests and how heavily and deeply coporate rot has penetrated into our institutions. I activly expect dishonesty on the part of corporate interest, and corporate interest is increasingly if not already entierly, government interest.

And yet, modern science involves humans, human interests, and human failings. Science practice is as flawed as the people that do it.

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#15
post #12

Earlier quoted context omitted.

I trust the sceince just fine, i dont trust corporate interests and how heavily and deeply coporate rot has penetrated into our institutions. I activly expect dishonesty on the part of corporate interest, and corporate interest is increasingly if not already entierly, government interest.

Do you have any examples of how the FDA is starting to put corporate interest ahead of public interest?

I’d say corporate and good-old-boy senior researcher clubs: https://www.nbcnews.com/news/amp/rcna63662

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#16
This seems like a scam...

The author claims that the FDA set impossible standards for getting this approved when it was originally discovered and that those same standards prevent them from seeking FDA approval now....but further down acknowledges that probiotics like this product are actually subject to much more lenient standards.

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#17

> The FDA demanded a study of 100 subjects, all of whom had to be “age 18-30, with removable dentures, living alone and far from school zones”. Hillman wasn’t sure there even were 100 young people with dentures, but the FDA wouldn’t budge from requiring this impossible trial. Hillman gave up and switched to other projects Interesting that the FDA can request such things. Would be a good way to block disruptive produc…

The FDA is often bad: https://jakeseliger.com/2023/07/22/i-am-dying-of-squamous-ce....

It is good at "protecting" people from things that might help them. Like many others, I'm being protected from treatments that might harm me, so the cancer I've got can kill me instead.

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#19

This seems like a scam... The author claims that the FDA set impossible standards for getting this approved when it was originally discovered and that those same standards prevent them from seeking FDA approval now....but further down acknowledges that probiotics like this product are actually subject to much more lenient standards.

I really hate to appeal to authority but Scott Alexander is the single last person on earth, and I am not exaggerating, who I would accuse of analyzing a topic in bad faith.

Re: A genetically modified bacterium that outcompetes bacteria causing tooth decay

#20
This story has been around for far too long and evidence is unbelievably weak, and the claims border on fraudulent.

1. The claim that this strain outcompetes the same S mutans from occupying the same niche cannot be true unless this strain is also capable of creating and tolerating environments with low pH. By definition if it creates acid to the same degree it will also cause cavities.

2. Single applications are insufficient to cause any persistent colonization. Even multiple daily applications of oral probiotics don’t lead to colonization. Oral probiotics function primarily through bacteriocins, not through colonization (except in very rare cases). This is because the existing microbiome is incredibly difficult to outcompete. The community in your mouth has evolved for as long as you have lived, and in some ways was shaped for generations before as it’s technically inherited from your ancestors.

3. S mutans is not the only species that causes cavities. S sobrinus, S wiggsiae, B dentium, about a dozen other acidogenic species also cause cavities.

Source: I’m a cofounder at Bristle Health, the oral microbiome company.

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