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High blood pressure may contribute to cognitive decline

nih.gov

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Re: High blood pressure may contribute to cognitive decline

#32
post #24
post #18

I'm of the belief obesity causes more than 90% of the health woes in western nations.

90% is a tad high, but I agree that it's likely both the biggest contributor and the simplest to address (not necessarily easy, as many of us know).

Or well, not until wegovy drops beneath 1000/a month at least

Re: High blood pressure may contribute to cognitive decline

#33

High blood pressure may be not a cause of cognitive decline, but just a consequence. This is what happens in malnutrition. Absence of nutrients and coenzymes (vitamins) leads to energy deficit and results in cellular damage, nervous system tries to compensate that by increasing blood flow, so it induces high blood pressure to have better chances of survival with increased blood perfusion and substrates delivery rate…

Interesting about the immune system link. I noticed my terrible hay fever eased a lot after my BP came way way down (from ~220 to 130-something).

Re: High blood pressure may contribute to cognitive decline

#35

This is very related to a theory I have that as my blood pressure has gotten higher over the years my ADHD also gets more difficult to manage. Guanfacine has also helped my symptoms more than anything and it was first brought to market as a blood pressure medication.

Do you have any more information about this? It would explain the challenge I've been experiencing as I enter my early 40s with a family history of hypertension; my blood pressure has been going up, which makes sense, but my ADHD has also been getting harder to manage, which doesn't.

Re: High blood pressure may contribute to cognitive decline

#37

Earlier quoted context omitted.

Sure but the research in the article shows that hypertension caused a specific form of cognitive decline and that the effect could be slowed even if the hypertension itself isn't fixed. So, basically the article says there are cases where the cognitive decline is a direct result of the hypertension, the opposite of your first sentence.

But they didn't reduce the hypertension metabolically. They just treated it directly with hypertension drugs. This suggests hypertension could just be a symptom (along with cognitive decline) caused by something else.

You are just speculating btw, a lot of people have primary hypertension with no apparent cause. Bodies are like that or there is some mystery ailment no one has ever been able to pinpoint, it's a leap to speculate that some hidden cause is also linked to cognitive decline.

Other causes of hypertension are very well known

Re: High blood pressure may contribute to cognitive decline

#38

This is very related to a theory I have that as my blood pressure has gotten higher over the years my ADHD also gets more difficult to manage. Guanfacine has also helped my symptoms more than anything and it was first brought to market as a blood pressure medication.

I'm another data point that confirms this. ADHD has become harder to manage close to when I was diagnosed with hypertension, almost to the point of complete executive dysfunction.

Guanfacine helps significantly.

I'm also on BP medication, and if I miss a couple of doses and my BP rises, it becomes impossible to think clearly. So the link to cognitive decline seems unsurprising to me.

Re: High blood pressure may contribute to cognitive decline

#40

This is very related to a theory I have that as my blood pressure has gotten higher over the years my ADHD also gets more difficult to manage. Guanfacine has also helped my symptoms more than anything and it was first brought to market as a blood pressure medication.

Do you have any more information about this? It would explain the challenge I've been experiencing as I enter my early 40s with a family history of hypertension; my blood pressure has been going up, which makes sense, but my ADHD has also been getting harder to manage, which doesn't.

I have a similar issue. Amphetamine gives me more side effects and seems to help less these days despite being a wonder drug thru my 20s. I’ve optimized my diet and exercise regularly, half because of this, but it only goes so far. I’m running out of levers to pull.
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