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High blood pressure may contribute to cognitive decline

nih.gov

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Re: High blood pressure may contribute to cognitive decline

#11

Post by garganzol »

High blood pressure may be not a cause of cognitive decline, but just a consequence.

This is what happens in malnutrition. Absence of nutrients and coenzymes (vitamins) leads to energy deficit and results in cellular damage, nervous system tries to compensate that by increasing blood flow, so it induces high blood pressure to have better chances of survival with increased blood perfusion and substrates delivery rate (glucose, lipids, oxygen, coenzymes). Immune system gets activated by metabolically impaired tissues creating even more damages at the affected areas.

Changing electrolyte balance of the body by giving extremely high amounts of salt is a sure way to disrupt the metabolism with all the consequences.

Re: High blood pressure may contribute to cognitive decline

#12

Post by Scoundreller »

garganzol wrote: post #9
okr wrote: post #6

Earlier quoted context omitted.

Stay young and don't breathe.

> don't breathe Lack of oxygen immediately contributes to cognitive decline.

Only in the long-term (ie: more than 5 seconds). But for those initial seconds, you're a bit better off!

Re: High blood pressure may contribute to cognitive decline

#13

Post by rqtwteye »

garganzol wrote: post #11

High blood pressure may be not a cause of cognitive decline, but just a consequence. This is what happens in malnutrition. Absence of nutrients and coenzymes (vitamins) leads to energy deficit and results in cellular damage, nervous system tries to compensate that by increasing blood flow, so it induces high blood pressure to have better chances of survival with increased blood perfusion and substrates delivery rate…

"High blood pressure may be not a cause of cognitive decline, but just a consequence."

Isn't that the same?

Re: High blood pressure may contribute to cognitive decline

#14

Post by financltravsty »

Hypertension -> blood vessel necrosis -> reduction in blood supply and nutrients to organs such as the brain -> declining mental health?

An interesting note is that of runaway hypertension when the kidneys become damaged by hypertension, decrease their ability to modulate blood pressure, thereby increasing hypertension, which damage the kidneys, which... so on.

Re: High blood pressure may contribute to cognitive decline

#15

Post by TeMPOraL »

rqtwteye wrote: post #13
garganzol wrote: post #11

High blood pressure may be not a cause of cognitive decline, but just a consequence. This is what happens in malnutrition. Absence of nutrients and coenzymes (vitamins) leads to energy deficit and results in cellular damage, nervous system tries to compensate that by increasing blood flow, so it induces high blood pressure to have better chances of survival with increased blood perfusion and substrates delivery rate…

"High blood pressure may be not a cause of cognitive decline, but just a consequence." Isn't that the same?

"Cause" is the literal opposite of "consequence", unless you're postulating a feedback loop.

Re: High blood pressure may contribute to cognitive decline

#16

Post by _zoltan_ »

garganzol wrote: post #11

High blood pressure may be not a cause of cognitive decline, but just a consequence. This is what happens in malnutrition. Absence of nutrients and coenzymes (vitamins) leads to energy deficit and results in cellular damage, nervous system tries to compensate that by increasing blood flow, so it induces high blood pressure to have better chances of survival with increased blood perfusion and substrates delivery rate…

can you elaborate on the salt part? are those good or bad consequences?

Re: High blood pressure may contribute to cognitive decline

#17

Post by arcticbull »

TeMPOraL wrote: post #15
rqtwteye wrote: post #13

Earlier quoted context omitted.

"High blood pressure may be not a cause of cognitive decline, but just a consequence." Isn't that the same?

"Cause" is the literal opposite of "consequence", unless you're postulating a feedback loop.

Depends how you read the line.

If you read it this way, they are the same.

> "High blood pressure may be not [be] a cause of cognitive decline, but [cognitive decline may] just [be] a consequence [of high blood pressure]."

The other interpretation makes less sense.

> "High blood pressure may be not a cause of cognitive decline, but just a consequence [of cognitive decline]."

The implication here is that cognitive decline causes high blood pressure, which doesn't make any sense.

The author I think was trying to say they have a common cause, but I don't believe there's any evidence for the mechanism on which their thesis relies.

Re: High blood pressure may contribute to cognitive decline

#19

Post by mobilejdral »

> In this study, mice were fed a high-salt diet

High salt levels increase Aldosterone (https://pubmed.ncbi.nlm.nih.gov/11327640/)

> However, blocking the brain blood vessels’ ability to respond to IL-17 only partially rescued cognitive impairment, suggesting that there was another source of IL-17 acting on the brain.

Just a guess, but

To produce Aldosterone the body also over produces cortisol resulting in less somatostatin, lowering IGF-1. IGF-1 stimulates the growth and division of both oligodendrocytes and schwann cells so lower IGF-1 would decrease myelin growth and induce cognitive impairment.

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