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Mid-old cells are a potential target for anti-aging interventions in the elderly

nature.com

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Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#111

Post by graphe »

johnnyworker wrote: post #109
graphe wrote: post #106

Earlier quoted context omitted.

None of those Wikipedia facts will prepare someone for death. Reciting what psychedelics are or describing color with words would yield the same result. Why would that knowledge help someone prepare for death?

Nothing can prepare a self-obsessed person for death. It is not my duty to prepare you for death or make it easy for you, it is my duty to be intellectually honest. The tapestry of live consists of all the individual threads (lives) and if someone of those threads never ended, new threads cannot be in the space they occupy. That's trivially true. And to me that does the same to the tapestry of live what a cancer cell…

You wrote a lot but said nothing except your own projecting of me as a self obsessed person. Your post just says accept death or I'll look down on you, because the universe and stars and assange? Lol.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#112

Post by insanitybit »

jodrellblank wrote: post #110
Tr03P wrote: post #33

Earlier quoted context omitted.

Why throw out the baby with the bath water, just because the rich will live longer, no one should. This is the feeling I get everytime I see a comment that it will be only for the rich and powerful. I don't think that will be the case, as there will be a gold rush once the possibility is proven and visible, everyone will try to get it, even the naysayers. It will be more like the crash of prices from the Spanish mine…

> " I don't think that will be the case, as there will be a gold rush once the possibility is proven and visible, everyone will try to get it, even the naysayers. " Maybe; instead when this happens, e.g. hairloss and finasteride, I look at people desperately trying to fight aging and stay young forever and then replacing their worry about hairloss with worry about post-finasteride[1] depression and sexual side effect…

Is your point that supplements have side effects? I don't think that's surprising to anyone at all.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#113

Post by jodrellblank »

insanitybit wrote: post #112
jodrellblank wrote: post #110

Earlier quoted context omitted.

> " I don't think that will be the case, as there will be a gold rush once the possibility is proven and visible, everyone will try to get it, even the naysayers. " Maybe; instead when this happens, e.g. hairloss and finasteride, I look at people desperately trying to fight aging and stay young forever and then replacing their worry about hairloss with worry about post-finasteride[1] depression and sexual side effect…

Is your point that supplements have side effects? I don't think that's surprising to anyone at all.

My point is that "once the possibility is proven and visible, everyone will try to get it, even the naysayers" is wrong. I could plausibly benefit from Finasteride, I'm not rushing for it even though I think it works. We can also see[1] which says "poor diet is recognized as the leading cause of death and disability in the United States, and the World Health Organization predicts that by 2020, two thirds of disease worldwide will exist because of a poor lifestyle.11-13 A large body of consistent evidence suggests eating a healthy diet can prevent, delay, or even reverse CVD, hypertension, hyperlipidemia, diabetes, and certain cancers.14-19 The effect of such intake is rapid and profound." - yet people aren't rushing for healthy diets and exercise, are they?

And I think your claim is wrong; a lot of people pop vitamin supplements like candy expecting that they are harmless and would be surprised to find they are capable of causing harm; anecdotally I have read of people saying exactly that, which is enough to disprove "wouldn't be surprising to anyone at all".

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506974/

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#114

Post by insanitybit »

jodrellblank wrote: post #113
insanitybit wrote: post #112

Earlier quoted context omitted.

Is your point that supplements have side effects? I don't think that's surprising to anyone at all.

My point is that "once the possibility is proven and visible, everyone will try to get it, even the naysayers" is wrong. I could plausibly benefit from Finasteride, I'm not rushing for it even though I think it works. We can also see[1] which says " poor diet is recognized as the leading cause of death and disability in the United States, and the World Health Organization predicts that by 2020, two thirds of disease…

> I'm not rushing for it even though I think it works

Because of the side effects, right?

> - yet people aren't rushing for healthy diets and exercise, are they?

Because that implies a lifestyle change. I think the assumption here is that this would be a treatment or a pill.

> And I think your claim is wrong; a lot of people pop vitamin supplements like candy expecting that they are harmless and would be surprised to find they are capable of causing harm;

I don't think that most people will be surprised to hear that taking any pill can have negative effects, though I do think that lots of people may be surprised by the dose at which those effects are seen, but there will always be outliers, of course, who may think that eating an entire carton of gummy vitamins is no big deal. But, I don't think that is really relevant, although I'm not sure what point you're trying to make still.

I think you're trying to say that some people won't rush to take this pill because it may have unintended side effects?

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#116

Post by justrealist »

BizarreByte wrote: post #86
RobotToaster wrote: post #72

Earlier quoted context omitted.

It is a concern, look at the current monoclonal antibody alzheimer's treatment that's insanely expensive. Generally though it's in the interest of the rich to extend the useful lifespan of their workers, training workers from babies is expensive, so it could be cheaper to keep the current ones going for 200 years.

> so it could be cheaper to keep the current ones going for 200 years. This sounds like a form of hell. I'd rather die than work for 200 years, I can already barely stomach working as long as I have to.

Unemployment is record low. You could get practically any job you want right now. Why are you working a job you hate?

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#117

Post by bryanrasmussen »

lr4444lr wrote: post #84
bryanrasmussen wrote: post #54

Earlier quoted context omitted.

the worry is of course that in 300 years Mark Zuckerberg will be having his big pan-American birthday part and all the plebes get treated to a 30 minute newsblast about it while eating their gruel. It's one thing to have music of lower quality, it's another to be old and dying and watching someone who was born a century before you gifted with youth and vitality. It's not hard to envision that situation if the rich ha…

That is so short-sighted. Practically all technological breakthroughs are expensive during the discovery and R&D process. Over time, engineering makes things more affordable at scale. And markets free to respond to supply and demand are the catalyst to make it work.

I'm sorry, you're arguing that immortality, something that would probably cause all sorts of upheavals in society, will slide through the system in the same way as a new improved way for cutting your lawn.

This of course is my reference to science fiction, people in relation to this particular subject have worries that are dystopia-fodder, which I have to admit may also be silly but will probably be closer to what will happen then betting it will work the same as the process that ended up giving everyone a personal computer.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#118

Post by bryanrasmussen »

Teever wrote: post #95
bryanrasmussen wrote: post #54

Earlier quoted context omitted.

the worry is of course that in 300 years Mark Zuckerberg will be having his big pan-American birthday part and all the plebes get treated to a 30 minute newsblast about it while eating their gruel. It's one thing to have music of lower quality, it's another to be old and dying and watching someone who was born a century before you gifted with youth and vitality. It's not hard to envision that situation if the rich ha…

In the scenario you describe what's stopping one of the plebes from killing Zuckerberg? If Zuckerberg has essentially doomed everyone else to death while he and his kin get to live on perpetually he's basically painted a giant target on his back that every one with 6 months to live on a totally curable terminal brain cancer diagnosis is going to want to hit. I'm not too worried about this kind of scenario because I k…

>In the scenario you describe what's stopping one of the plebes from killing Zuckerberg?

Lots of people want to kill lots of different Billionaires, but billionaires ain't dropping like flies.

>very one with 6 months to live on a totally curable terminal brain cancer diagnosis is going to want to hit.

unless getting a terminal brain cancer makes people John Wick in the universe this movie is taking place in, I don't think that's how the plot will play out.

Re: Mid-old cells are a potential target for anti-aging interventions in the elderly

#120

Post by BobaFloutist »

graphe wrote: post #51
kalium-xyz wrote: post #3

Earlier quoted context omitted.

Its further evidence for a hypothesis on the mechanism of aging. Personally I just wanna know how aging works

Don't your telomeres get shorter, your DNA gets damaged and it doesn't replicate correctly anymore? Some animals can be immortal like lobsters but face limits like their physical size can kill them when they molt enough.

If aging was just DNA errors, wouldn't it be far less consistent in how it effected people?
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