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One sleepless night can rapidly reverse depression for several days in mice

news.northwestern.edu

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Re: One sleepless night can rapidly reverse depression for several days in mice

#211
This duplicates research that is at least 20 years old.

Also, depressed people (and people with similar mental conditions) resist sleep also partially because being tired means that you feel less, and thus are relieved from the pain you feel more acutely when more awake.

Re: One sleepless night can rapidly reverse depression for several days in mice

#213
post #202

Earlier quoted context omitted.

That's exactly where my brain went. Now I need a Huberman Labs podcast telling me how I can incorporate this with my supplements and cold showers to achieve my maximum potential.

Don't forget to microdose shrooms as well, please.

Forget the microdose, sleep deprivation and macrodose shrooms go together like PB&J. Never met someone who could fall asleep under the effects of psychedelics.

Re: One sleepless night can rapidly reverse depression for several days in mice

#214
post #59

Earlier quoted context omitted.

It's an experimental study not an observational study. So that correlation won't have an effect here

Not so sure; the whole article is about people having a reason to pull an all nighter. Students mostly. That’s intense motivation breaking a stereotype, recipe for a high

... it's a mouse study

Re: One sleepless night can rapidly reverse depression for several days in mice

#216

Having suffered from severe depression for over forty years, this reminds me of when I was 17, 18, etc. and suddenly discovered that if I stayed up for two days, the problem went away. So I knew this a very long time ago; but it always seemed to me that, besides smoking, this was just about one of the worst habits you could develop. By my mid-twenties, I had stopped.

I recently was forced off of SSRIs after nearly ten years because I lost my psychiatrist and couldn't get a new one because the waitlists were ridiculous. After 10 years on them, the next 6 months were absolute hell (i legit thought at one point I might go full Joaquin Phoenix in Joker) but I made it through, no small part thanks to my wonderful amazing wife. Rebound depression have been an issue - though in general…

I get them (sertraline and escitalopram) pretty much on demand from Hims and Lemonaide.

Re: One sleepless night can rapidly reverse depression for several days in mice

#217
post #52

https://www.reddit.com/r/hangovereffect/ This sub-reddit is dedicated to people who've noticed this effect for ADHD and probably depression as well. Drinking alcohol somehow causes the same 'reversal' of symptoms, either motivation or other mood problems. Lots of discussion as to what causes it - and questions/theories on how to reproduce without alcohol. Alcohol causing sleeplessness, or sleep that's not the usual q…

I have ADHD, did never tried it with alcohol, but sleep deprivation works. I used it when working on important projects with deadlines. You kind of feel like in a parallel universe after a couple of a day if it's a interesting subject for you, ADHD gives you hyper focus, and sleep deprivation gives you this energy to push thru. It's like you don't even need the medication. If you combine it with ADHD medications it's…

I definitely remember a couple times in school pulling absolutely heroic crunches to get a semester's worth of work done in a couple days. Worse one was Freshman year finals week, didn't sleep for just shy of 4 days, fueled by a mountain of caffeine, amphetamine, and sleepless delirium. During day 3 I started wearing an eye patch so that I could give each eye a temporary rest from the strain.

Finished everything, flew home, and slept for 18 hours straight.

Re: One sleepless night can rapidly reverse depression for several days in mice

#218

Earlier quoted context omitted.

I had a period when I used THC (edibles) for sleep every night. This was one of the worst things I have ever done to myself. At first, you don't notice much side effects, but slowly it creeps up on you. It makes you depressed, depletes of any motivation, gives brain fog and you may just feel weird over all. When I quit I was amazed by how much better I started feeling and by how much my cognitive function improved. I…

~10 years from now we’re going to have better data on chronic THC consumption and after being a heavy user I’m pretty confident it’s going to shock a lot of people with negative externalities. Tip for getting off weed - start by lowering the damn dosage. A lot of commonly used products are the equivalent of a triple shot. And folks do it daily.

I used to use THC heavily, but the negative effect was noticable in multiple aspects. So I stopped for a while. Now I take full spectrum CBD oil that I make myself. It has a low amount of THC in it, which boosts the overall effects. It's a much better experience than taking high THC strains imo.

Re: One sleepless night can rapidly reverse depression for several days in mice

#219

Earlier quoted context omitted.

Try Type III cannabis (high cbd hemp). Nowadays it looks and smells like Type I cannabis (the high thc standard variety of weed). It has all the various combinations of cannabinoids, terpenes, and flavonoids that contribute to the entourage effect except for THC ( i.e. amongst non-psychoactive hemp flower there are relaxing indicas for insomnia, functional hybrids for chronic pain, sativas for a pick-me-up, etc.

I've not tried it yet, but CBN seems to be the winner in this category. It's legal in all states if pure. Black Friday is coming and I plan on getting some from a vendor I've used in the past. Ping me for that info if you wish. YMMV.

Try buying a quarter pound of CBD hemp and turn it into a small amount of concentrated oil. I want to spread the word, this is the way. The best bang for your buck and highest quality oil you can get, better than most commercially available edible products. I wrote some more info and my process on another comment on here. If your interested, I can write more here too.

Re: One sleepless night can rapidly reverse depression for several days in mice

#220

Having suffered from severe depression for over forty years, this reminds me of when I was 17, 18, etc. and suddenly discovered that if I stayed up for two days, the problem went away. So I knew this a very long time ago; but it always seemed to me that, besides smoking, this was just about one of the worst habits you could develop. By my mid-twenties, I had stopped.

Seems that I'm in the opposite. If I don't get enough sleep I would have noticeable bad mood.

Bad mood isn't the same as chronic depression though...
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