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One sleepless night can rapidly reverse depression for several days in mice

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Re: One sleepless night can rapidly reverse depression for several days in mice

#12
post #5

... in mice.

> In a new study, researchers induced mild, acute sleep deprivation in mice and then examined their behaviors and brain activity. Not only did dopamine release increase during the acute sleep loss period, synaptic plasticity also was enhanced — literally rewiring the brain to maintain the bubbly mood for the next few days.

What’s a mouse like when it’s in a bubbly mood?!

Re: One sleepless night can rapidly reverse depression for several days in mice

#14
The "morning hormonal" dump that gets offset by not sleeping could easily shift neuro-chemistry.

For (sufficiently) depressed people, any perceived shift is likely going to be a improvement.

Related, similar studies have postured that nights with occasional stirrups lead to a more rested day, un-intuitively.

The variation in sleep requirements within groups may have more obvious evolutionary benefits; the security of camps overnight depend on those who stay up overnight to stand guard or occasionally tend to the fire.

Re: One sleepless night can rapidly reverse depression for several days in mice

#17
post #12
post #5

... in mice.

> In a new study, researchers induced mild, acute sleep deprivation in mice and then examined their behaviors and brain activity. Not only did dopamine release increase during the acute sleep loss period, synaptic plasticity also was enhanced — literally rewiring the brain to maintain the bubbly mood for the next few days. What’s a mouse like when it’s in a bubbly mood?!

Perhaps we misread, and "their" refers to the researchers, not to the mice!

Re: One sleepless night can rapidly reverse depression for several days in mice

#18

Queue people blogging about their monthly “sleep fast” for optimized mood and focus.

plenty of people force themselves to stay up all night once in a blue moon for mental health reasons, all without blogging about it.

Re: One sleepless night can rapidly reverse depression for several days in mice

#19

This must be why new parents always seem so bubbly and happy! But seriously, that’s very interesting and explains what I’ve experienced. I’ve been in a depression since quitting my phd a couple months ago and not having a direction in life, but whenever I have trouble sleeping I end up feeling better the next day. Maybe I’ll trying utilizing it to get my portfolio looking better.

I noticed something similar (see also: my comment about using magnesium and getting better sleep on the thread about deep sleep yesterday). When I get ~5ish hours of sleep one night a week I am surprisingly more alert the next day but I also crash much harder by night. I cannot sustain multiple days of little sleep but one short night doesn't seem to have such a detrimental effect.

I wonder if this is why ADHD people struggle with sleep.
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