Here's something I've been wondering that maybe some smart hackernews-ian can explain to me. I watched a spider build a web last night. A ton of extremely complicated engineering went into it, all driven by pure instinct, presumably coded in DNA somewhere. If you gave me enough time I could lay out how a semi-conducting material turns into a T-gate transistor, which can be chained with other transistors to create AND…
DNA turbine powered by a transmembrane potential across a nanopore
21–30 of 30 posts
Re: DNA turbine powered by a transmembrane potential across a nanopore
#22Earlier quoted context omitted.
Also interested in the answer, and I thought a bit about this and have a hypothesis that DNA does not encode everything, instead it depends on implicit assumptions about the environment. To give an example, gravity is likely not encoded in the DNA, but instead, there are many encoded behaviors that would make sense only on an environment where gravity is present. The same for the presence of predators, wind, solar ra…
Interesting! I like that thought. I enjoy thinking about how surprisingly good we are at predicting trajectories, good enough that we can throw, catch, and dodge small objects with remarkable accuracy. I wonder if our internal calculations of acceleration due to gravity is purely learned, or future space-faring infants will be surprised by how their block castles react when they knock them over.
Re: DNA turbine powered by a transmembrane potential across a nanopore
#23Here's something I've been wondering that maybe some smart hackernews-ian can explain to me. I watched a spider build a web last night. A ton of extremely complicated engineering went into it, all driven by pure instinct, presumably coded in DNA somewhere. If you gave me enough time I could lay out how a semi-conducting material turns into a T-gate transistor, which can be chained with other transistors to create AND…
That said, I think the most faithful description is something like a dynamical system with incredibly structured and robust emergent behavior. This means that the underlying rules of biology are simple, just physics, but life/biology maintains very complex states. So there’s this bug difference between how much information it takes to describe a biological system’s state and how much information it takes to describe the underlying rules. Like to describe myself, I would have to know the state of quadrillions of proteins and molecules across about 30 trillion cells, down to atomic precision. To describe how that state changes, I only need to know a few physics equations.
For most software the situation is more or less reversed. To describe a program, there’s a few state variables, and a ton of rules describing how the program manipulates those variables.
The consequence of this for biology is that there’s no true abstraction between the spatial or time scales. Like, a few atoms in the wrong place can often lead to effects across the whole organism. Think genetic mutations leading to cancer: a single DNA base change drastically changes the whole organism. But, the arrow can also point the other way. Large scale changes like deciding to smoke or take chemotherapy causes molecular changes that then filter up to whole organism changes.
Like I said, it’s hard to describe because some of these properties are also true for human engineered systems so it’s tempting to use our existing engineering abstractions to describe life. But, they’re woefully insufficient for capturing some of the most important characteristics of life. My opinion on the matter is that we just don’t have good ways of deciding how life works because we don’t really understand it; there are fundamental laws at work that we haven’t captured mathematically or even conceptually.
Re: DNA turbine powered by a transmembrane potential across a nanopore
#24Here's something I've been wondering that maybe some smart hackernews-ian can explain to me. I watched a spider build a web last night. A ton of extremely complicated engineering went into it, all driven by pure instinct, presumably coded in DNA somewhere. If you gave me enough time I could lay out how a semi-conducting material turns into a T-gate transistor, which can be chained with other transistors to create AND…
Re: DNA turbine powered by a transmembrane potential across a nanopore
#25Earlier quoted context omitted.
thanks for sharing. since you sound like an expert, do you know if this technique works for live imaging of RNA molecules or would tagging such a small molecule potentially alter biological processes and contaminate results? [edited to clarify live-imaging requirement]
I am not exactly an expert, I just happened to do a deep dive into microscopy techniques a couple years ago :-) The general term for these types of techniques (e.g., ones that let you image things below the "diffraction limit", which is roughly half the wavelength of light being used to image, see [1]), is super resolution microscopy[2]. There are a few other types you might find interesting. 1: https://en.wikipedia.…
based on your understanding, do you think it's possible to do live imaging of RNA molecules super resolution microscopy references DNA imaging but doesn't delve into contamination risk, which is the critical bit.
the first link didn't mention DNA/RNA applications at all.
do you mind sharing the other types you recommend investigating?
Re: DNA turbine powered by a transmembrane potential across a nanopore
#26Here's something I've been wondering that maybe some smart hackernews-ian can explain to me. I watched a spider build a web last night. A ton of extremely complicated engineering went into it, all driven by pure instinct, presumably coded in DNA somewhere. If you gave me enough time I could lay out how a semi-conducting material turns into a T-gate transistor, which can be chained with other transistors to create AND…
Here is not a very good answer to your question, but think about how you know how to walk. It's something that is not entirely conscious. You legs just move between places that you desire to go without any thought to the angle of your knee or tension in your gluts. You feel unbalanced when you center of gravity is too far forward despite having no conscious understanding of where exactly your center of gravity is in…
A newly born antelope calf has 3 minutes to figure this all out before it becomes prey.
Re: DNA turbine powered by a transmembrane potential across a nanopore
#27A man-made ATP synthase?! Very cool!
Re: DNA turbine powered by a transmembrane potential across a nanopore
#28Here's something I've been wondering that maybe some smart hackernews-ian can explain to me. I watched a spider build a web last night. A ton of extremely complicated engineering went into it, all driven by pure instinct, presumably coded in DNA somewhere. If you gave me enough time I could lay out how a semi-conducting material turns into a T-gate transistor, which can be chained with other transistors to create AND…
biology and physics operate at more dimensions where physical forces conspire to be leveraged by some neat tricks. Chemical gradients, various pressures, mechanical forces, electrostatic gradients, all sorts of differences out there to ride--some are passive, some are actively produced and take energy.
Re: DNA turbine powered by a transmembrane potential across a nanopore
#29Earlier quoted context omitted.
Interesting! I like that thought. I enjoy thinking about how surprisingly good we are at predicting trajectories, good enough that we can throw, catch, and dodge small objects with remarkable accuracy. I wonder if our internal calculations of acceleration due to gravity is purely learned, or future space-faring infants will be surprised by how their block castles react when they knock them over.
When we duck away from low flying birds, it’s probably because they used to hunt us a million years ago.
Re: DNA turbine powered by a transmembrane potential across a nanopore
#30Earlier quoted context omitted.
Interesting! I like that thought. I enjoy thinking about how surprisingly good we are at predicting trajectories, good enough that we can throw, catch, and dodge small objects with remarkable accuracy. I wonder if our internal calculations of acceleration due to gravity is purely learned, or future space-faring infants will be surprised by how their block castles react when they knock them over.
When we duck away from low flying birds, it’s probably because they used to hunt us a million years ago.