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Are colonoscopies worth it?

asteriskmag.com

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Re: Are colonoscopies worth it?

#5
Colonoscopies come with potential for complications.

There are actually a number of companies which have either released or plan to release non-invasive colorectal cancer screening based on blood dna sequencing.

GRAIL, Freenome, and Guardant all have tests out or coming down the pipeline.

Re: Are colonoscopies worth it?

#6

You mean I get scoped every few years and it’s not even a thing??!

The problem with medical interventions, especially tests, is that they sometimes work. There will always be success stories.

The big question is: are those success stories worth it, and are there other paths to those same success stories.

Re: Are colonoscopies worth it?

#8
This is actually a nice summary of how a clinical trial is more than just "did it have a positive or negative result?".

Every single trial introduces some bias through the way it's designed. Good trials try to minimize bias or at least limit it to things we know don't introduce bias.

The article does a nice job at digging into the nuances of the trial design and how it may influence (or not influence) the results.

That's why the "reference wars" you see on HN are so pointless. It's easy to just find a paper that supports your position. But trials are of varying quality.

What you see in this article is what normally happens with most major trials - results get discussed, challenged, discussed some more. After a few months doctors finally settle on the main takeaways. Sometimes it takes years.

Re: Are colonoscopies worth it?

#9

As far as I know, countries outside the USA that recommend it are Switzerland, Germany, and Austria: https://publichealthreviews.biomedcentral.com/articles/10.11...

I was going to post the same thing – Poland launched a nationwide campaign two years ago to get all people over 50 years old (above 40 if they had family history) in for a colonoscopy. However, the linked article is working with a European study done a decade ago (EDIT: I’m wrong about that). There may have once been greater differences between American and European approaches.

Re: Are colonoscopies worth it?

#10

As far as I know, countries outside the USA that recommend it are Switzerland, Germany, and Austria: https://publichealthreviews.biomedcentral.com/articles/10.11...

I was going to post the same thing – Poland launched a nationwide campaign two years ago to get all people over 50 years old (above 40 if they had family history) in for a colonoscopy. However, the linked article is working with a European study done a decade ago (EDIT: I’m wrong about that). There may have once been greater differences between American and European approaches.

Data does not seem to indicate better survival odds so whats the point?
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