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Study shows antibodies against PEG in 83% of the German population

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Re: Study shows antibodies against PEG in 83% of the German population

#11

Post by throwawaymaths »

tjrgergw wrote: post #2

> It has long been known that people can form defenses and thus antibodies against viruses. But antibodies can also develop against polyethylene glycol (PEG), a substance used in cosmetics, food and medicine. People can develop antibodies against things which are not foreign micro-organisms. TIL. (Obvious once you think about it. What you really develop antibodies to are proteins on the surface of micro-organisms) We…

PEG is not a protein. And you can definitely get antibodies against anything. There's an idiot researcher trying to get people to make antibodies against cocaine.

The bonkers thing about this is that adding PEG is supposed to be a strategy to get things to evade the immune system.

Re: Study shows antibodies against PEG in 83% of the German population

#12

Post by unsupp0rted »

geraldhh wrote: post #10
unsupp0rted wrote: post #8

Huh, I take PEG in (large?) quantities before colonoscopies.

> colonoscopies the plural makes me curious; for medical reasons?

I get a colonoscopy every n years. Where n is some number between 1 and 5, depending on whether they found polyps or something the previous time.

It's not that onerous, except that I assume going under propofol + midazolam comes with cognitive risks each time, and this might be cumulative.

With that in mind, no idea how the risk/reward math of regular endoscopy/colonoscopy checkups works out.

Re: Study shows antibodies against PEG in 83% of the German population

#13

Post by appplication »

unsupp0rted wrote: post #12
geraldhh wrote: post #10

Earlier quoted context omitted.

> colonoscopies the plural makes me curious; for medical reasons?

I get a colonoscopy every n years. Where n is some number between 1 and 5, depending on whether they found polyps or something the previous time. It's not that onerous, except that I assume going under propofol + midazolam comes with cognitive risks each time, and this might be cumulative. With that in mind, no idea how the risk/reward math of regular endoscopy/colonoscopy checkups works out.

Having seen now 3 people die of colon cancer in their early 30s, I can see why early and frequent detection makes sense.

Re: Study shows antibodies against PEG in 83% of the German population

#15

Post by mensetmanusman »

When I lived in Germany, I learned that one interesting, cultural aspect is that they don’t drink nearly as much tapwater as in America.

This means everyone buys water in plastic containers at the grocery store, all this plastic is PET-based, and PEG is always present in small quantities in that water (because water is slightly acidic, and acids disassociate the PET molecule).

Re: Study shows antibodies against PEG in 83% of the German population

#16

Post by kragen »

mensetmanusman wrote: post #15

When I lived in Germany, I learned that one interesting, cultural aspect is that they don’t drink nearly as much tapwater as in America. This means everyone buys water in plastic containers at the grocery store, all this plastic is PET-based, and PEG is always present in small quantities in that water (because water is slightly acidic, and acids disassociate the PET molecule).

how the fuck do you get peg from ethylene terephthalate

Re: Study shows antibodies against PEG in 83% of the German population

#18

Post by sigmar »

s5ma6n wrote: post #6

Apparently PEG is/was the one of the reasons of the severe allergic reactions in mRNA COVID-19 vaccines (Moderna, Pfizer)[0] That's plastics for you folks... [0]: [Translated from German]( https://www-aerzteblatt-de.translate.goog/archiv/217236/COVI... )

Not a plastic and it is commonly found in food and cosmetics.

>evidence shows the existence of a detectable level of anti-PEG antibodies in approximately 72% of the population, never treated with PEGylated drugs, based on plasma samples from 1990 to 1999. Due to its ubiquity in a multitude of products and the large percentage of the population with antibodies to PEG, hypersensitive reactions to PEG are an increasing concern.[39][40] Allergy to PEG is usually discovered after a person has been diagnosed with an allergy to an increasing number of seemingly unrelated products, including processed foods, cosmetics, drugs, and other substances that contain PEG or were manufactured with PEG

https://en.wikipedia.org/wiki/Polyethylene_glycol

Re: Study shows antibodies against PEG in 83% of the German population

#19

Post by kragen »

i guess they'll just have to use lalr(1)

more seriously, i wonder if something like this is a cause of the obesity pandemic: an unrecognized widespread immune response to a novel food additive provoking continuous low-level inflammation

though probably not peg itself; e1521 is not in that many foods, not like xanthan gum or nanoparticles of titanium dioxide

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