171–180 of 317 posts
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Yes, some of those things do sound silly... but they are not at all what most Christians believe.
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What's missing from this article is that people are reaching for this because the standard medical treatment for these disorders, SSRIs, are pretty terrible. In the mild case, the common side effects are blunting of your emotions and sexual dysfunction. So you don't have panic attacks, but you live in a gray fog and your relationships suffer. In the worst case, they cause suicidal ideation. Psychedelics also have psy…
Counterpoint: SSRIs were transformative for my depression. Side effects were minor and manageable (eg, Wellbutrin worked well to prevent any sexual dysfunction). I was on them for several years and had no problem tapering off. My understanding is that this is a pretty typical experience. Rhetoric like this was actively harmful in dissuading me for years from trying what ended up being by far the most effective treatm…
> That is, there are a bunch of tests that ask you a bunch of questions about your feelings and symptoms, and you can add them up and call that a “depression score”, and if you do that, antidepressants have an effect size of 0.3. Or you can ask patients “how depressed do you feel on a scale of 1-10”, and if you do that, antidepressants have an effect size of 0.5. I think the latter is better, because it’s what we actually care about (how patients are doing), and the tests are kind of dumb and ask about a lot of symptoms most people realistically aren’t experiencing.
(In other words, if you ask a patient with depression how they are feeling, and they say 'great', and then you ask them questions like "are you managing to shower every day", or "did you think about suicide a lot this week" and they give the same answers as a depressed person, they are cured!)
Does weird napkin math which clearly can't be justified:
> For those people, they will have a large real effect size of 1.0, plus a large placebo effect size of 0.9, for a very large total effect size of 1.9.
(How do you get to add the placebo effect back on to the postulated 'large real effect size'??)
Says that extremely common side effects are 'very unusual':
> It can be any or all of decreased libido, difficulty orgasming, difficulty getting an erection, difficulty enjoying sex, or decreased sensation in the genitals. These usually go away a few weeks to months after stopping the medication, but in rare cases they might linger for months or years, and there are a few people who say their sexual side effects never went away. These cases are very unusual and still not well understood.
(Note that in the same article he points out that, in general, the medication only improves mood or anxiety while you keep taking it, when you stop taking it you still have the depression or other conditions. So the fact that sexual disfunction usually gets resolved after stopping taking the medication isn't much relief. For most people SSRIs will never lead to a steady state where you are stable with regards to your mental health issue and also are able to enjoy sex.)
Makes armchair psych connection between well-studied things which are not the same:
> When everything goes right, SSRIs blunt negative but not positive emotions. But many people even at reasonable doses will notice that their most extreme positive emotions become a little less extreme (this may be part of the problem with sex).
(Difficulty getting aroused or orgasming or feeling in the mood for sex is not the same as "most extreme positive emotions becoming a little less extreme")
What's missing from this article is that people are reaching for this because the standard medical treatment for these disorders, SSRIs, are pretty terrible. In the mild case, the common side effects are blunting of your emotions and sexual dysfunction. So you don't have panic attacks, but you live in a gray fog and your relationships suffer. In the worst case, they cause suicidal ideation. Psychedelics also have psy…
Counterpoint: SSRIs were transformative for my depression. Side effects were minor and manageable (eg, Wellbutrin worked well to prevent any sexual dysfunction). I was on them for several years and had no problem tapering off. My understanding is that this is a pretty typical experience. Rhetoric like this was actively harmful in dissuading me for years from trying what ended up being by far the most effective treatm…
For what it's worth, synthetic opioids and spinal fusion saved my life. If I'd listened to the Internet, I'd have likely never pursued treatment or maybe just taken Kratom and gotten massages or something, fearing I'd end up a drug addict with a worse spine than I started with.
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I’m pretty agnostic, but what are you answers to seemingly untraceable questions of life, meaning, and existence? I’m starting to come around to the view that ridicule of religiosity is quite often more vacuous than spirituality.
That God kinda-became human to "sacrifice" himself (with no loss, got up 3 days later to live forever, nothing was sacrificed) in order to forgive the sins of people, but only if they believe it, isn't spiritual, it's silly. You owe someone something, and someone else or that person pays it for you -- but if you don't believe that happened, it never happened. Great stuff. I don't need to have an answer for life, the…
Now, you are the author of the entire creation. At any point you can intervene in any way you want, for instance to relocate an entity that was very far from the light to be much closer to it. And you do indeed do this quite regularly. In fact a large amount of what you do as the author is go out to find the entities that are very far from the light and shepherd them back to be close to it. Sometimes, this relocation sticks: the entity sees the light, recognizes it, and continues to pursue it. Sometimes, it doesn't: the entity either wanders around aimlessly with no regard for the direction of the light, or indeed it actively pursues darkness.
At the end of the generation you have a spectrum of entities: those who never left the light, those who strayed occasionally but always took to your shepherding back, ..., all the way to those who actively ran away from the light at every opportunity. So yes, you are the author. You have complete control over how all these entitles move into the next generation, and you can save all of them if you'd like. But why would you?
Earlier quoted context omitted.
Counterpoint: SSRIs were transformative for my depression. Side effects were minor and manageable (eg, Wellbutrin worked well to prevent any sexual dysfunction). I was on them for several years and had no problem tapering off. My understanding is that this is a pretty typical experience. Rhetoric like this was actively harmful in dissuading me for years from trying what ended up being by far the most effective treatm…
I don't think Scott Alexander's page is a 'relatively objective resource'. He is, as you point out, a 'psychiatrist who regularly prescribes them' and also used to take them. It is full of special pleading where he relitigates extremely high quality meta-analyses to overlay his own opinion: > That is, there are a bunch of tests that ask you a bunch of questions about your feelings and symptoms, and you can add them u…
What I am on now (Lexapro) was life changing in a good way, with only minor sexual side effects that more or less went away.
As such, studies that day "SSRIs have this effect on people" or "have these side effects" are fundamentally flawed. Despite belonging to a common class, there isn't a universal experience.
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Yeah, that's the thing, who knows? So who has any right to ridicule anyone else for having a different perspective? Just choose whatever narrative that floats your boat and live and let live.
Ridiculing is one thing. Waging holy war, murdering, burning and dehumanizing is unfortunately a common reaction to differing viewpoints among religious folk.
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They are certainly an order of magnitude more powerful than pot. You can fairly easily have a psychologically very difficult experience at larger doses. I’m all for people trying them but the effects shouldn’t be underestimated. I’ve had powerful feelings of anxiety, love, euphoria, mania or sadness on different times. Very different from pot which has a pretty uniform and predictable effect on me.
You can fairly easily have a very difficult experience with pot too. I have way worse and stronger experiences with pot than with mushrooms/LSD. Cannabis is quite a powerful drug for many. A lot more powerful than most "hard drugs" like stimulants, empatogens, opioids or sedatives, which don't "mind fuck" at all unless you do them days on end or ridiculous dosages.
No one is getting ego-death and dimensional transcendence from ripping dabs of THC concentrate all night. Just lots of paranoia and distress.
Earlier quoted context omitted.
Counterpoint: SSRIs were transformative for my depression. Side effects were minor and manageable (eg, Wellbutrin worked well to prevent any sexual dysfunction). I was on them for several years and had no problem tapering off. My understanding is that this is a pretty typical experience. Rhetoric like this was actively harmful in dissuading me for years from trying what ended up being by far the most effective treatm…
Some cause permanent changes in the brain. No thanks.
Earlier quoted context omitted.
I don't think Scott Alexander's page is a 'relatively objective resource'. He is, as you point out, a 'psychiatrist who regularly prescribes them' and also used to take them. It is full of special pleading where he relitigates extremely high quality meta-analyses to overlay his own opinion: > That is, there are a bunch of tests that ask you a bunch of questions about your feelings and symptoms, and you can add them u…
Personal anecdatum, different SSRIs affect people differently. Some that others here have praised didn't help, or had bad side effects. What I am on now (Lexapro) was life changing in a good way, with only minor sexual side effects that more or less went away. As such, studies that day "SSRIs have this effect on people" or "have these side effects" are fundamentally flawed. Despite belonging to a common class, there…
This news will probably come as a huge surprise to the psychiatric epidemiologists who carried out the peer-reviewed research that Alexander mangles! They probably thought all SSRIs were exactly the same!
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The problem here is that there is no evidence. All the evidence of negative effects so far is anecdotal, which in reality calls for more research in the area [0]. In addition, only about 0.2% report having sought emergency treatment [1] when using psylocibin. [0] https://journals.plos.org/plosone/article?id=10.1371/journal... [1] https://journals.sagepub.com/doi/full/10.1177/02698811221084...
As someone who partakes in psychedelics to a moderate degree, I don’t think it makes any sense at all to dismiss the very many negative outcomes as “no evidence”. Perhaps it’s under-researched, but your comment strikes me as ideological and/or hyperbole. Like with all treatments, it’s a careful balance of whether the risks are worth the positive health outcomes. But there’s no sense in denying that psychedelics, and…