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New pill helps Covid smell and taste loss fade quickly

nature.com

21–30 of 154 posts

Re: New pill helps Covid smell and taste loss fade quickly

#22
What would be the process for getting this drug approved for use in the US? I wonder if it would qualify for the EUA pathway, on the grounds that it's possible there is a limited window during which it is effective. Has this drug been used for other purposes, which would help regulators know whether it is generally safe? Or would they be assessing it from square one?

Re: New pill helps Covid smell and taste loss fade quickly

#23
Oooh yes yes - this is such wonderful news! Literally weeks before the world changed my boyfriends dad had begun to explore the world of cooking; he was so happy when we would bring him to niche little grocers to try things he had never known about before and trying all the food - but after his infection, and for the last 2 years - nothing. No taste. No smell.

We try to make up for it by encouraging him to make stuff with varied textures and components but he's been really depressed about it since. His pinterest recipe board he would share with us hasn't been updated in years and his meals typically consist of protein/starch/veggie with no seasoning as it doesn't register.

I am so hopeful for something that can bring him his sense of smell and taste back; so far his medical teams have kinda just been bouncing him around to various specialties - he even had a small surgery in an attempt but no dice.

Re: New pill helps Covid smell and taste loss fade quickly

#24
Girlfriend has lost her entire sense of smell after covid, I'm really hoping the future has an answer to that.

It's taken the joy out of a lot of things she enjoys, especially cooking. She's seen a few ENT doctors and they all claim it's not coming back without any clear solutions.

Re: New pill helps Covid smell and taste loss fade quickly

#25
post #2

I've now had Covid 3 x times. The first time I had incredible taste and smell loss, taking in excess of 4-5 months to recover, perhaps not even fully. The other times, I had no loss of taste or smell. I do wonder why it only impacted me the first time. Different Covid variant, or something biologically changed in me, causing it to impact me differently?

The first time I contracted COVID, the other symptoms were wild, and I gave myself even odds on dying. However I did not lose my sense of smell or taste. The second time I contracted COVID, it was mostly just a miserable fever but I lost my smell and taste, and they still have not come back completely almost a year later. My theory is that COVID does a random walk when eating away the brain from wherever it enters.

Maybe it matters if when you originally contracted it you were breathing in through your mouth vs nose?

Re: New pill helps Covid smell and taste loss fade quickly

#26
post #2

I've now had Covid 3 x times. The first time I had incredible taste and smell loss, taking in excess of 4-5 months to recover, perhaps not even fully. The other times, I had no loss of taste or smell. I do wonder why it only impacted me the first time. Different Covid variant, or something biologically changed in me, causing it to impact me differently?

I am reasonably certain I had covid in January 2020; felt like I had been hit by a truck, and recovery took weeks.

As far as I know, I haven't had it since, but did get the vaccinations. Do you (does anyone here) know if there is a test to see if you did have it, or does the vaccine response swamp that signal?

Re: New pill helps Covid smell and taste loss fade quickly

#27

What would be the process for getting this drug approved for use in the US? I wonder if it would qualify for the EUA pathway, on the grounds that it's possible there is a limited window during which it is effective. Has this drug been used for other purposes, which would help regulators know whether it is generally safe? Or would they be assessing it from square one?

According to the article (and Wikipedia), it's a novel antiviral developed to treat COVID-19, and has reached (or completed, by now?) Phase III trials in Japan, and is currently in use there under an EUA (although I assume the acronym may be different in Japan).

If this works for people who have had smell & taste lost for years after recovery, that would imply that the ongoing symptoms were the result of a lingering infection. I'm not sure the referenced study demonstrates that -- as near as I can tell, it was clinically evaluated in people who had new COVID-19 infections.

Re: New pill helps Covid smell and taste loss fade quickly

#28
Have there been studies on the potential advantages of loss of smell and/or taste from COVID-19?

Westerners are too obese, and presumably part of that's to do with the enjoyment people get from unhealthy foods.

Whereas if you can't taste anything food's basically differently textured fuel of varying temperatures. You'd have to desire to eat e.g. yogurt with added sugar over one without.

Re: New pill helps Covid smell and taste loss fade quickly

#29

Earlier quoted context omitted.

The first time I contracted COVID, the other symptoms were wild, and I gave myself even odds on dying. However I did not lose my sense of smell or taste. The second time I contracted COVID, it was mostly just a miserable fever but I lost my smell and taste, and they still have not come back completely almost a year later. My theory is that COVID does a random walk when eating away the brain from wherever it enters.

Maybe it matters if when you originally contracted it you were breathing in through your mouth vs nose?

And those many who didn't lose either smell or taste were breathing through...?

Re: New pill helps Covid smell and taste loss fade quickly

#30
post #2

I've now had Covid 3 x times. The first time I had incredible taste and smell loss, taking in excess of 4-5 months to recover, perhaps not even fully. The other times, I had no loss of taste or smell. I do wonder why it only impacted me the first time. Different Covid variant, or something biologically changed in me, causing it to impact me differently?

I've been buying "test bags" of mandarins every 4 months or so since I contracted it for a second time around Christmas 2021. Yesterday was the first time that I was able to taste any of the background notes you would normally associate with orange flavors. Before it was like just taking a concentrated spray of orange oil to the mouth. I was so excited I ended up eating half the bag, lol.

That makes me happy to hear! I have a couple of friends who have been affected by this, and their loss of food enjoyment has genuinely hurt them. Here's hoping they get theirs back soon, too.
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