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Low serotonin levels might explain some Long Covid symptoms, study proposes

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Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#71

Post by PrayagBhakar »

thesid wrote: post #60
thenerdhead wrote: post #32

For people who are obviously ignorant of long covid in this thread, go read these publications and watch these videos: https://www.thelancet.com/journals/laninf/article/PIIS1473-3... https://www.nature.com/articles/s41590-023-01601-2 https://www.nature.com/articles/s41586-023-06651-y https://www.youtube.com/watch?v=z189Z7tS1w4 https://www.youtube.com/watch?v=VYNMzaZk_iU The researchers here have a specific hypothesis…

[flagged]

I’m confused why folks think long covid isn’t real? Most disease have long lasting effects. Why not covid?

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#72

Post by throwaway6977 »

local_crmdgeon wrote: post #63
zero_shift wrote: post #22

Earlier quoted context omitted.

Is it that we over-diagnose long COVID? Or that we under-diagnose post viral fatigue more generally? I remember a close family member having a nasty viral infection aged 32/33 - not exactly old and frail - and they left it a very different person in terms of energy and general health. It really did take a year or so to clear up.

We over diagnose. It's taboo to discuss the fact that population is tumblr/twitter types, and not people that are well adjusted. It's a contagion, but it's not spread by a virus. Most people with Long COVID recover through increased exercise and improved diet. They're just depressed, which is of course a real illness, but it's more to do with burn out from social media hysteria. Any mention of this on HN results in i…

You get down voted because there are thousands of people suffering from real physical symptoms of this - like clots and tachycardia - and you are waving away the symptoms as a mental illness.

What a joke; I hope no one ever does that to you.

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#73

Post by stevenwoo »

ETH_start wrote: post #2

For the vast majority of cases, a long COVID diagnosis is extremely short on rigor. The best evidence available suggests most cases of "long COVID" are misattribution: https://jamanetwork.com/journals/jamainternalmedicine/fullar...

Obviously it's potentially very different across species but we've found what appears to be a way COVID-19 damages dogs that exhibited no ordinary symptoms of disease, in what I think was every dog infected in the study. So perhaps a human would show no symptoms after infection but still have damage from infection via a similar route.

https://wwwnc.cdc.gov/eid/article/29/11/23-0804_article

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#74

Post by NickM »

catskul2 wrote: post #66
BjoernKW wrote: post #48

Earlier quoted context omitted.

Sexual dysfunction, for one: https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_i... Additional potential long-term side effects include, but are not limited to, weight gain, feeling emotionally numb, and an increased suicided risk. Furthermore, there's the SSRI discontinuation syndrome: https://en.wikipedia.org/wiki/Antidepressant_discontinuation... SSRIs are truly fun stuff.

Half of the side effects are also the side effects of abating depressions. It's theorized that the suicide risk from most anti-depressants are from transitioning from so depressed that you have no motivation to do anything, to having enough motivation, but still feeling the related pain from depression. Likewise with weight-gain. For many depressed people they have a suppression of appetite, and relieving the depress…

AFAIK, neither the sexual side effects nor the withdraw symptoms are generally considered to be long term much less permanent.

They’re often not permanent, but particularly with sexual problems there is a significant minority of people who do not get better after they stop the drugs. The term to search for is “PSSD” (post-SSRI sexual dysfunction).

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#75

Post by local_crmdgeon »

throwaway6977 wrote: post #72
local_crmdgeon wrote: post #63

Earlier quoted context omitted.

We over diagnose. It's taboo to discuss the fact that population is tumblr/twitter types, and not people that are well adjusted. It's a contagion, but it's not spread by a virus. Most people with Long COVID recover through increased exercise and improved diet. They're just depressed, which is of course a real illness, but it's more to do with burn out from social media hysteria. Any mention of this on HN results in i…

You get down voted because there are thousands of people suffering from real physical symptoms of this - like clots and tachycardia - and you are waving away the symptoms as a mental illness. What a joke; I hope no one ever does that to you.

Should we not be Trusting the Science? This paper is The Science.

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#76

Post by mg »

thenerdhead wrote: post #43
mg wrote: post #27

I'm surprised there is no randomized controlled trial of the effect of Vitamin D on Long Covid. When I browse through Pubmed and read studies (a/b-tests) of Vitamin D intake and respiratory tract infections (including Covid), many large studies found a positive effect.

Vitamin D is preventative in nature. Also there are trials here...look them up on clincialtrials.gov https://clinicaltrials.gov/study/NCT05633472 https://clinicaltrials.gov/study/NCT05356936 https://clinicaltrials.gov/study/NCT05630339 https://clinicaltrials.gov/study/NCT04536298

Good to see that there are some studies under way now.

How do you mean "preventative in nature"? Are you aware of any studies which a/b tested Vitamin D on active respiratory tract infections which showed that the Vitamin D has no effect in this situation?

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#78

Post by avisser »

jinder wrote: post #33
RohMin wrote: post #20

Earlier quoted context omitted.

While most of the body’s serotonin is indeed in the gut, the serotonin that impacts our mood, sleep, and other cognitive functions is exclusively produced and used in the brain.

While the serotonin used in your gut doesn’t directly impact the brain, it does impact the enteric nervous system which communicates via the vagus nerve to your brain. So I don’t think it’s correct to say this doesn’t (or couldn’t) impact your mood (and indeed murine experiments demonstrate it does).

Perhaps my favorite science experiment, next to dual-slit, https://radiolab.org/podcast/197242-gut-feelings

They cut the vagus nerves of rats and see behavior change.

Which makes sense to me - when "brains" first evolved, the connection to the stomach would've been the prime connection.

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#79

Post by runamuck »

local_crmdgeon wrote: post #67
user568439 wrote: post #58

Earlier quoted context omitted.

So are you saying that my wife got depressed 2 weeks after having Covid? That she just all of the sudden started to be breathless with oximeter showing levels below 80% due to a depression? She was in her best moment in life, earning a 6 figures salary, reading 50 books a year, learning a 5th language and studying a 2nd master degree. After 2 years, she is now unable to leave home and read a single book of course thi…

To be fair literally every single symptom here is a symptom of depression. Has she tried SSRIs? People get depressed from disease all the time, being sick is depressing.

Depression can cause dangerously low Blood Oxygen?

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#80

Post by mcpackieh »

local_crmdgeon wrote: post #63
zero_shift wrote: post #22

Earlier quoted context omitted.

Is it that we over-diagnose long COVID? Or that we under-diagnose post viral fatigue more generally? I remember a close family member having a nasty viral infection aged 32/33 - not exactly old and frail - and they left it a very different person in terms of energy and general health. It really did take a year or so to clear up.

We over diagnose. It's taboo to discuss the fact that population is tumblr/twitter types, and not people that are well adjusted. It's a contagion, but it's not spread by a virus. Most people with Long COVID recover through increased exercise and improved diet. They're just depressed, which is of course a real illness, but it's more to do with burn out from social media hysteria. Any mention of this on HN results in i…

"It can't be depression because my wife has it. You need to do more research, please subscribe to doomerist facebook groups to read all about it."
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