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Low serotonin levels might explain some Long Covid symptoms, study proposes

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Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#21
post #3

Elder friend of mine got the fatigue two weeks after covid. after everything else was ruled out she was given ssris for anxiety, and indeed she could walk again a few weeks later. If this turns out to be as interesting as it sounds, well buy SSRI maker stocks

> If this turns out to be as interesting as it sounds, well buy SSRI maker stocks

Really? SSRIs are outside of patent so there is little moat and thin margins.

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#22

For the vast majority of cases, a long COVID diagnosis is extremely short on rigor. The best evidence available suggests most cases of "long COVID" are misattribution: https://jamanetwork.com/journals/jamainternalmedicine/fullar...

Is it that we over-diagnose long COVID? Or that we under-diagnose post viral fatigue more generally?

I remember a close family member having a nasty viral infection aged 32/33 - not exactly old and frail - and they left it a very different person in terms of energy and general health. It really did take a year or so to clear up.

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#23
post #3

Elder friend of mine got the fatigue two weeks after covid. after everything else was ruled out she was given ssris for anxiety, and indeed she could walk again a few weeks later. If this turns out to be as interesting as it sounds, well buy SSRI maker stocks

Not to deny your friends experience, but just to shed light on an issue common with chronic illnesses:

People naturally heal all the time from illnesses like this. They just get better with time.

People also get desperate (and sometimes their doctors) and try all manner of remedy.

You get a situation where people who naturally recover end up attributing that recovery to whatever random remedy they were trying at the time. This can be compounded by having bands of people who got sick around the same time, tried whatever flavor of the month remedy was talked about at the time, and recovered around the same time.

Having long covid myself since summer 2020, I've watched this play out more times than I can count now.

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#24
post #3

Elder friend of mine got the fatigue two weeks after covid. after everything else was ruled out she was given ssris for anxiety, and indeed she could walk again a few weeks later. If this turns out to be as interesting as it sounds, well buy SSRI maker stocks

This is interesting to me, I'm recovering from COVID right now and the fatigue hit me - you guessed it - two weeks after the initial infection. I don't take an SSRI but perhaps it could indeed help.

Be careful, they can seriously impair your ability to feel sexual pleasure long term.

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#25
post #3

Elder friend of mine got the fatigue two weeks after covid. after everything else was ruled out she was given ssris for anxiety, and indeed she could walk again a few weeks later. If this turns out to be as interesting as it sounds, well buy SSRI maker stocks

Not to deny your friends experience, but just to shed light on an issue common with chronic illnesses: People naturally heal all the time from illnesses like this. They just get better with time. People also get desperate (and sometimes their doctors) and try all manner of remedy. You get a situation where people who naturally recover end up attributing that recovery to whatever random remedy they were trying at the…

This happens all the time with sports overuse injuries also. Kinesio tape, acupuncture, chiropractor adjustments, heat, ice. People try all kinds of things, eventually you get better. Whatever you tried last seems like it helped. But who knows.

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#26

For the vast majority of cases, a long COVID diagnosis is extremely short on rigor. The best evidence available suggests most cases of "long COVID" are misattribution: https://jamanetwork.com/journals/jamainternalmedicine/fullar...

A study from 2021 using data from early that year is going to be woefully out of date by now.

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#27
I'm surprised there is no randomized controlled trial of the effect of Vitamin D on Long Covid.

When I browse through Pubmed and read studies (a/b-tests) of Vitamin D intake and respiratory tract infections (including Covid), many large studies found a positive effect.

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#28

So basically most long covid is a form of depression. It makes sense given the fact that most self reported long covid was white middle aged females over any other demographic

The greatest demographic to report long covid symptoms are actually hispanic and black people trans people earning less than 25000 a year. [0]

0. https://www.census.gov/library/stories/2023/05/long-covid-19...

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#29
post #20

My gut reaction (pun intended) or guess on what causes Long Covid is a viral reservoir, possibly in the gut, that the immune system cannot fully clear. Low serotonin is then a downstream effect from the chronic stress on the body. Approx. 90% of serotonin found in the human body is located in the (GI) tract. So people and doctors will throw SSRIs at the problem, and maybe that will relieve some symptoms, but will not…

While most of the body’s serotonin is indeed in the gut, the serotonin that impacts our mood, sleep, and other cognitive functions is exclusively produced and used in the brain.

Was going to say this. My one gripe with HN is that people say incorrect things with complete confidence pretty regularly and you can only Detect it if you know the subject matter.

Re: Low serotonin levels might explain some Long Covid symptoms, study proposes

#30

For the vast majority of cases, a long COVID diagnosis is extremely short on rigor. The best evidence available suggests most cases of "long COVID" are misattribution: https://jamanetwork.com/journals/jamainternalmedicine/fullar...

I’ve seen it compared to the gulf war syndrome which happened to returning soldiers, a similar thing they spent forever looking for a cause (gas attacks etc) and never finding a physical cause. They determined it’s something that happens to people after a widespread traumatic event. Like a minor version of PTSD.

I’d love to see a study that took long COVID people and got them to do daily cardio exercise, go outside into nature, and sleep better (ie not over sleeping) and seeing if the symptoms improve vs a placebo group that sits inside all day reading doomer posts about COVID on Twitter/Facebook.

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