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Lab leak fight casts chill over virology research

nytimes.com

201–210 of 253 posts

Re: Lab leak fight casts chill over virology research

#201

Earlier quoted context omitted.

> I simply do not trust for profit drug companies to do this work. I certainly don't trust governments to do it either. But you trust nature to do this work? ;-) > Further, the idea that we can correctly estimate how nature is going to perform and then front run those outcomes in the laboratory is entirely insane and is explicitly anti-science. Well, this eliminates a great deal of research areas completely outside v…

> But you trust nature to do this work? ;-) What work is that? Unnaturally bringing bats and pangolins together in a meat market? The only "real world" excuse ever offered. > Climatologists aren't needed. I've read their reports and their annual revisions. I'm not convinced they're needed, and since the "science" here is purely a wild guess using models projected backwards in time to fit existing data, the results ar…

> What work is that? Unnaturally bringing bats and pangolins together in a meat market? The only "real world" excuse ever offered.

GoF research in virology is specifically to replicate what happens in nature in hopes of forecasting outcomes and giving us more time to respond to them. If it isn't doing what happens in nature, it is, by definition, a failure.

> I've read their reports and their annual revisions. I'm not convinced they're needed, and since the "science" here is purely a wild guess using models projected backwards in time to fit existing data, the results aren't particularly meaningful either.

Those "guesses" have proven to amazingly insightful. You may not find them useful, but even energy companies have found these forecasts useful for their business.

> Do any of these require you to invent novel phenomenon to "study?" If not, then your comparison is purely the making of a strawman.

Yes, they do. More precisely, I would say they involve artificially controlled experiments that are used to forecast outcomes in nature.

...and I wasn't making a comparison or a strawman. I was taking your statement as an assertion, and identifying that in fact many scientific fields employ methods that you describe as "anti-science".

> Interestingly.. was any "forecast" of the virus they created in a lab provided to anyone?

No. One might almost think that perhaps "the virus" wasn't created in a lab. It's unlikely, given the large number of virologists who've said it wasn't created in a lab, but maybe?

> Even if we did have it, would it have made a difference in timelines?

Yes. Hugely, particularly for testing. Most of the vaccine development cycle is tied up in testing for safety and such, so the impact there is smaller, but it's not zero.

> You clearly see the exact problem.

I do. I don't think it's the same problem that you are seeing.

Re: Lab leak fight casts chill over virology research

#202
Or, you know, "Lab Leak of Coronavirus casts chill over virology research".

I know it's not definitive it was a lab leak, but many US agencies including, notably, the Department of Energy, say it's likely it was.

And when you change the headline to reflect that, it sure does change the message.

Re: Lab leak fight casts chill over virology research

#203

Earlier quoted context omitted.

Certain gain of function experiments, e.g. modifying an animal virus to be able to infect humans could create viruses that might behave very similar to SARS-CoV2 if leaked. We now know more about the potential consequences of such a leak, we have a full-blown pandemic as a benchmark. If those experiments have a chance to repeat a similar pandemic, I don't think any of them are worth that risk.

> If those experiments have a chance to repeat a similar pandemic, I don't think any of them are worth that risk. You're saying that without regard to the measure of risk, or what risks exist if we don't do those experiments.

What risk could possibly be worse than a global pandemic? That seems to be what gain of function research purports to be studying to prevent- and in this case it appears that the research virus caused the very thing it was supposed to (indirectly) prevent.

Re: Lab leak fight casts chill over virology research

#204

Earlier quoted context omitted.

Eh, more incorrect, probably. With earthquakes you at least have stress accumulating over time, even if the stress is not necessarily accumulating or being released at a constant rate. A zoonotic spillover is pure repeated throws of the dice, no accumulated pressure.

Not quite true: zoonotic crossover events become more likely as more animals are brought together. Large-scale wet markets or bushmeat markets increase the chances because there are more rolls of the dice .

Are most zoonotic crossovers more than one step or are most misadventures NONHUMAN => HUMAN? Either way if market activity doesn't change year on year then rate of dice rolls don't change on that front.

However there is no reason to believe that such misadventures take place in a single generation and immediately produce a viable and successful agent.

Producing something that spreads to humans but not will will none the less produce many orders of magnitude more useful and numerous dice rolls. Such actions may not be immediately obvious even if they were fatal. People after all get sick and die all the time.

I doubt we have enough data to meaningfully forecast risk.

Re: Lab leak fight casts chill over virology research

#205
The fundamental problem with GoF research is that the virology community has shown that it's not trustworthy enough to be working with things that are this dangerous.

In China, there has been almost a complete information blackout after COVID. Most of what we know that points to a leak that actually comes from China has been accidentally disclosed or was published before the pandemic.

In the U.S. and Europe, it's sadly largely the same story. We now know through FOIA requests that the authors of the pivotal Proximal Origin thought privately that there was a significant likelihood that SARS2 was lab derived, but what they published was that "we do not believe that any type of laboratory-based scenario is plausible." They also sought to conceal some of the true authors of the paper in order for it to appear more independent and credible. They, and their colleagues then relentlessly smeared and called conspiracy theorists, anyone who publicly said the very same things that they said privately to each other.

EcoHealth and DARPA refused to provide a copy of the DEFUSE grant proposal. It ultimately had to be leaked by an anonymous source in the government. When it finally came out it ended up being more or less a direct blueprint for how you'd create SARS2 from existing bat viruses, and it was submitted just a year before the outbreak started in Wuhan. One of the collaborators on that project was to have been the Wuhan Institute of Virology.

Throughout, (and there is much more), not a single person who has brought any of this to light has been a virologist. Some have been biologists in other fields, some have been outside the scientific establishment entirely.

Being responsible for an animal that harbors a virus that could kill 10,000,000 people or more if you make a mistake is an awesome responsibility, and only people of the utmost integrity can be trusted with something that dangerous. What we've seen is that sadly, nowhere near this level of integrity exists in the virology community.

Re: Lab leak fight casts chill over virology research

#206
post #192
post #141

Earlier quoted context omitted.

We don't know if the virus came from a market either, so why would that be the default position? Especially since that position requires accepting a hell of a coincidence that the virus just happened to emerge near a lab working on gain of function research for that type of virus. China's lack of openness to investigating this should also skew us against giving them the benefit of the doubt, rather than the opposite.…

Every pandemic ever has been caused by a natural source. Most pandemics happened before virology was a field. The default assumption from the start was animal source until there's proof it was something else.

>Every pandemic ever has been caused by a natural source.

That's an awfully bold claim, unless you have proof that covid-19 occurred naturally. Defaulting to your preferred reality and ignoring the potential risks is not a responsible way to guide research policy.

Re: Lab leak fight casts chill over virology research

#207

Earlier quoted context omitted.

No-one cares (it's a non-topic) so not sure what a survey even means then (and the survey is 6 months old).

The first rule of digging a hole is stop. But I’ll bite. You are saying that people in Europe over the last six month think that a lab leak is less likely now than they had? Hmm, hot take.

No. I am saying I don't know what it means to ask people about something in a survey that isn't a topic of discussion, i.e., asking about things that people don't care about.

There will be an opinion but that doesn't mean anyone cares about it or there is discussion about it.

Re: Lab leak fight casts chill over virology research

#208

Earlier quoted context omitted.

People are selfish. COVID may have started in China as a lab leak but the US likely funded it. Plenty of selfish reasons for people in government to squash the idea that COVID was a lab leak. If the lab leak turns out to be true I could see people demanding that the gallows be dusted off.

Even if it was accidentally leaked? That's extreme. I work with transgenic, not viruses, but mistakes happen and the death penalty for researchers is crazy.

Should we tolerate a culture of accidents and face preserving around nukes, grey goo (which this falls under?) there are things you only get to fail once..

Re: Lab leak fight casts chill over virology research

#210

Earlier quoted context omitted.

Do you actually need GoF research to prevent animal spillovers? Did GoF research help us develop the COVID vaccines? Or does GoF research mostly demonstrate the risks of spillover? Because I think we're now well aware of the risks, and ought to avoid poking the bear any further.

This paper at least [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490979 ] argues that GoF research (in particular done in 2015 regarding transplantation of spike proteins into SARS-CoV-1) was instrumental in prediction of the rate of mutation of the spike protein, which factors into models of virulence, reinfection, immunity, whether the spike is a viable target for creation of a vaccine at all, etc. It also there…

> instrumental in prediction of the rate of mutation of the spike protein

The research must have been pretty misleading then, because all the experts appeared to be taken by surprise by the fact that it mutated at all, given their original plan was "two shots and done". Something that has now become promoting infinity boosters to a world that has stopped listening (uptake of the current round is extremely low).

But again, why should we listen to claims about virology? People who have been living in ivory caves may not realize this, but it's been proven beyond all doubt that the entire profession engaged in a conspiracy against the public to mislead people about the likelihood of a lab experiment gone wrong. Not just the many authors of the proximal origins paper, but so the other scientists who saw this coverup happening in public and said nothing.

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