Universal cancer vaccine trial shows significant improvement in overall survival
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Re: Universal cancer vaccine trial shows significant improvement in overall survival
#2This is obviously good but note that it appears to be covering mesothelioma only, and "The median [overall survival] OS was 15.4 months (95% CI, 11.1-22.6) for UV1 plus ipilimumab and nivolumab (treatment arm) versus 11.1 months (95% CI, 8.8-18.1) for ipilimumab and nivolumab alone." Another headline could be: "Cancer vaccine helps some mesothelioma patients live an extra 4.3 months," which is less exciting than the headline's current phrasing. It's like how people are horrified by "you have a 20% chance of dying" but somewhat reassured by "you have an 80% chance of living."
I'm dying from squamous cell carcinoma and am more excited about the Moderna approach with personalized cancer vaccines, like mRNA-4157. Early data for what I have is promising: https://www.fiercebiotech.com/biotech/moderna-s-keytruda-com...: "The combination treatment shrank tumors in five patients with head and neck cancer (50%), eliminating the tumors in two of those patients, Moderna said in a statement. Another four patients in that group had stable disease, meaning their tumors had stopped growing." Recurrent/metastatic head and neck squamous cell carcinoma is almost always fatal: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155962/, unless the person responds to pembrolizumab/Keytruda (which I do not; about 20 - 30% of patients appear to respond, based on KEYNOTE-048: https://ascopubs.org/doi/full/10.1200/JCO.21.02508). Unfortunately, Moderna won't make mRNA-4157 available under compassionate use or through any other means. :(
Moderna, however, is in a Phase III study of mRNA-4157 in melanoma: https://www.onclive.com/view/adjuvant-mrna-4157-plus-pembrol.... Given the miraculous early data for R/M HNSCC, one hopes they'll launch new trials.
Nivolumab is a PD-1 inhibitor, like pembrolizumab/Keytruda, but I don't know anything more about it.
Re: Universal cancer vaccine trial shows significant improvement in overall survival
#3I have a friend doing her PhD in cancer research. She tells me to take every Phase I trial with a huge grain of salt, because they rarely make it to market. [1]
Re: Universal cancer vaccine trial shows significant improvement in overall survival
#4This is obviously good but note that it appears to be covering mesothelioma only, and "The median [overall survival] OS was 15.4 months (95% CI, 11.1-22.6) for UV1 plus ipilimumab and nivolumab (treatment arm) versus 11.1 months (95% CI, 8.8-18.1) for ipilimumab and nivolumab alone." Another headline could be: "Cancer vaccine helps some mesothelioma patients live an extra 4.3 months," which is less exciting than the…
"Phase II studies are ongoing in patients with malignant melanoma, head and neck cancer, ovarian cancer, and non-small cell lung cancer."
Re: Universal cancer vaccine trial shows significant improvement in overall survival
#5I have a friend doing her PhD in cancer research. She tells me to take every Phase I trial with a huge grain of salt, because they rarely make it to market. [1] 1: https://i.postimg.cc/L4G0FdWf/cancer-study.jpg
These are Phase II trials.
Re: Universal cancer vaccine trial shows significant improvement in overall survival
#6This is obviously good but note that it appears to be covering mesothelioma only, and "The median [overall survival] OS was 15.4 months (95% CI, 11.1-22.6) for UV1 plus ipilimumab and nivolumab (treatment arm) versus 11.1 months (95% CI, 8.8-18.1) for ipilimumab and nivolumab alone." Another headline could be: "Cancer vaccine helps some mesothelioma patients live an extra 4.3 months," which is less exciting than the…
Weren’t you able to get into the study at UCSD? How is that going? Are you allowed to talk about it?
Re: Universal cancer vaccine trial shows significant improvement in overall survival
#7I have a friend doing her PhD in cancer research. She tells me to take every Phase I trial with a huge grain of salt, because they rarely make it to market. [1] 1: https://i.postimg.cc/L4G0FdWf/cancer-study.jpg
Is this image from something with stats? The numbers seem kind of round.
Not that specific stats would help me that much.
Re: Universal cancer vaccine trial shows significant improvement in overall survival
#8This is obviously good but note that it appears to be covering mesothelioma only, and "The median [overall survival] OS was 15.4 months (95% CI, 11.1-22.6) for UV1 plus ipilimumab and nivolumab (treatment arm) versus 11.1 months (95% CI, 8.8-18.1) for ipilimumab and nivolumab alone." Another headline could be: "Cancer vaccine helps some mesothelioma patients live an extra 4.3 months," which is less exciting than the…
Do you have an opinion on https://www.science.org/content/blog-post/new-mode-cancer-tr...?
Re: Universal cancer vaccine trial shows significant improvement in overall survival
#9This is obviously good but note that it appears to be covering mesothelioma only, and "The median [overall survival] OS was 15.4 months (95% CI, 11.1-22.6) for UV1 plus ipilimumab and nivolumab (treatment arm) versus 11.1 months (95% CI, 8.8-18.1) for ipilimumab and nivolumab alone." Another headline could be: "Cancer vaccine helps some mesothelioma patients live an extra 4.3 months," which is less exciting than the…
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Re: Universal cancer vaccine trial shows significant improvement in overall survival
#1027% doesn’t seem all that significant considering a vaccine