31–40 of 89 posts
Anecdotal sample of one here: since starting the treatment a year ago, I have hardly set foot in a fast food restaurant, and my visits to other food establishments have been reduced by 75% at minimum. Grocery shopping has been more mindful and smaller in size. The impact on my desire or even ability to consume food beyond the base metabolic necessity is real.
Anecdotal experience - Good friend of mine who struggles with weight was taking Ozempic for about two months. He described nausea quite often when I saw him but the results were pretty astounding. He then hit a wall where gastroparesis would happen quite often and I happened to be at his house when one of these bouts got very severe. He went from feeling bad, to hunched over in pain and started projectile vomiting in…
His doctor isn't monitoring correctly. They should drop the dose. Standard treatment is start with a really smart dose then you double it each month for 5 months. In reality, if you're losing weight, you should just keep on that dosage.
It's going to be very interesting to see how the people who insisted on getting off-label prescriptions fare in court.
Wegovy is incorrectly listed in the article as a diabetes medication, it is only approved for weight loss. It is also 30% more expensive. https://www.wegovy.com/
Hm. May have located the problem.
This is considered to be the first generation of weight loss drugs that work. There will probably be better ones.
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We can! But should we? Being fat is similar to being a drug user. At first, you actually are fat and happy. Over time, being fat will absolutely reduce your happiness from the medical, societal, and physical issues that arise. Similar to how drug users build up a tolerance and instead of using the drug to be happy, they use the drug to feel normal. And just to state a simple fact, I do not condone shaming people with…
I have thought of this before. But it isn't really the same. Drugs, the really bad ones will probably ruin your life or kill you in the space of two or three years. Being fat unless it's super super severe often won't start impacting your health seriously until your 30's or 40's. on the opposite side anorexia will kill you much faster than obesity
That's just the more serious longterm effects. The reversible short term ones are immediate.
I was at a birthday hike for a friend - up a short granite hill for good views, some slow meandering around a lake. Very relaxed stuff. One of her guests couldn't make it up the hill. Full on bawling, had to leave early. This woman could not participate in even a casual hike for a friends party and she clearly wanted to be able to.
I was fat but below the obesity level before I started my whole thing and the first "benefit" I noticed was that I could do any physical activity. I might be bad at it, but I could rock climb, and kayak, and play basketball with people. The "Oh, I can't do that" was simply _gone_.
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All the non-diabetics using it will generate great data.. for the rest of us.
Unfortunately not really, because the infrastructure that allows us to glean insights from actual healthcare practices is abysmal/nonexistent, at least in the US. It became clear during COVID that a lot of people seem to presume there's some way for researchers to just "look at what's happening," and there isn't.
Pancreatitis is already a listed side effect of GLP-1 agonists, right?
> Seven CVOTs enrolling 56,004 patients with T2DM were identified, with a median follow-up time ranging from 1.3 to 5.4 years. [...] Conclusion: Pooled analysis of CVOTs did not suggest any increased risk of either acute pancreatitis or pancreatic cancer with GLP-1RA treatment in T2DM patients.
Initially my appetite almost completely went away, but then it came back to what felt like normal. There were days where I felt like I was eating too much or binging, but the weight kept coming off at about 2lbs per week. Also, being free from the food noise was incredibly liberating because I'm otherwise always thinking about food.
I ended up stopping because I would get incredibly sleepy at about 10pm to the point where staying up was almost impossible. I tried eating more thinking it was a blood sugar issue, but that didn't help. It just didn't work with my schedule.
I plan to get back on it, or an alternative like Mounjaro.