It might be insignificant, but to me it makes UUID feel tainted, dirty. 11.1% of a UUID are dashes. 15.3% of a UUID are wasted bits if you count version and variant bits.
Anecdote: I worked for a company that used numeric primary ids internally and externally and increased the primary key by TWO to THREE for each new customer to make it appear to the outside world we had twice to three times the rate of customer growth.