111–120 of 312 posts
They have a pitch deck lamenting 90% of US adults have cavities, and they are 2x likely to get untreated if you are poor, then propose to market this for 20k$/dose. Saving the world, again, startup style.
This is certainly an interesting idea, but there's absolutely no way for anyone to judge whether the claim on this page is bulletproof true, something plausible worth researching more, or just total nonsense. But the fact that there isn't a single link to any scientific paper or evidence whatsoever, or even a single person's name linked to the site (or source of funding or anything ), makes me assume this is just spa…
I work in medical startup space and the evidence we develop to prove our technology works typically has a higher threshold than what I've seen presented. I would want to see significantly more work done to demonstrate the scientific validity of this research. Do they intend to carry out any additional pre-clinical research (in vitro/in vivo)? Do they intend to do a clinical trial? It appears from their slide deck that they don't?
Earlier quoted context omitted.
Why are they not pushing against fluoride en masse, then?
Because they can charge $40-$80 (or more) for a fluoride treatment. It's actually how they make money on cleanings. If you don't opt for the fluoride treatment it's a wash.
They have a pitch deck lamenting 90% of US adults have cavities, and they are 2x likely to get untreated if you are poor, then propose to market this for 20k$/dose. Saving the world, again, startup style.
Earlier quoted context omitted.
Because they can charge $40-$80 (or more) for a fluoride treatment. It's actually how they make money on cleanings. If you don't opt for the fluoride treatment it's a wash.
> they can charge $40-$80 (or more) for a fluoride treatment. It's actually how they make money on cleanings This is nonsense. Many dentists, mine included, don’t apply fluoride. (They trust you to use toothpaste.)
This is certainly an interesting idea, but there's absolutely no way for anyone to judge whether the claim on this page is bulletproof true, something plausible worth researching more, or just total nonsense. But the fact that there isn't a single link to any scientific paper or evidence whatsoever, or even a single person's name linked to the site (or source of funding or anything ), makes me assume this is just spa…
The main papers referenced by document on the page are by JD Hillman on 1987[0] (et al) and 2002[1]. A layman review was done few years later by PopSci[2]. This specific site and company appear to have no relation to Hillman or Oragenics (co-founded by Hillman) that holds a patent on this[3,4].
[0]: https://journals.sagepub.com/doi/abs/10.1177/002203458706600...
[1]: https://link.springer.com/article/10.1023/A:1020695902160
[2]: https://www.popsci.com/scitech/article/2008-01/germ-could-sa...
[3]: https://www.oragenics.com/news-media/press-releases/detail/3...
They have a pitch deck lamenting 90% of US adults have cavities, and they are 2x likely to get untreated if you are poor, then propose to market this for 20k$/dose. Saving the world, again, startup style.
$20k per dose Jesus H Christ. Rent seeking galore. Hopefully the patent has run out by now and others can get in on the action and make it affordable. There’s no way in hell this could possibly cost $20k. Is capitalism ever going to produce innovation that’s affordable to regular people again and not just benefiting the profiteering VC parasite class?
The FDA requirements for the original clinical trial were wild: "...the FDA required them to find a cohort of 300 healthy 18-30 year olds who lived alone, not near a school zone, and had fully removable teeth." I can see why this makes sense, but no wonder they failed at enrolling the cohort.
A conversation with my friend who was a dentistry student, ~2013. > [The friend, let's call her L, trying to dissuade me from drinking some fizzy drink] > J: But I won't get a cavity if the liquid doesn't touch my teeth. > L: Cavities are caused by the ensuing low ph environment, not by contact with teeth > J: Does that mean I can drink as much of it as I want as long as I rinse my mouth with water afterwards? > L, w…
Use the interdental toothpicks made of wood.