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Scientists improve anti-tumor power of CAR-T cells

insideprecisionmedicine.com

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Re: Scientists improve anti-tumor power of CAR-T cells

#31

Post by klipt »

DoreenMichele wrote: post #23
GiorgioG wrote: post #20

Earlier quoted context omitted.

Plenty of “healthy” people die of cancer. My sister in law passed away at 49. She had no family history of cancer, ate healthy, ran daily, was not overweight for her entire life.

I do have a family history of cancer. My mother, sister, brother, father, multiple aunts and grandmother have had it one or more times. I've had it zero times.

Good diet and exercise can lower your risk. They cannot eliminate risk. You can do everything right and still get cancer.

Thus diet and exercise are also not reasonable substitutes for researching better treatments for those who do get cancer.

Re: Scientists improve anti-tumor power of CAR-T cells

#32

Post by klipt »

DoreenMichele wrote: post #19
gropo wrote: post #14

Earlier quoted context omitted.

ill never eat PFAS again

Good for you. Want to share any good websites you have for how to support your goal here? If I'm eating PFAS, I'd like to know.

PFAS (aka "forever chemicals") are present in everything including drinking water and breast milk so yes, you are eating PFAS.

Re: Scientists improve anti-tumor power of CAR-T cells

#33

Post by DoreenMichele »

klipt wrote: post #31
DoreenMichele wrote: post #23

Earlier quoted context omitted.

I do have a family history of cancer. My mother, sister, brother, father, multiple aunts and grandmother have had it one or more times. I've had it zero times.

Good diet and exercise can lower your risk. They cannot eliminate risk. You can do everything right and still get cancer. Thus diet and exercise are also not reasonable substitutes for researching better treatments for those who do get cancer.

I don't think diet and exercise are the full story. My initial comment says diet and lifestyle, not diet and exercise.

I'm trying to step away from this discussion. It is kind of off topic and I don't think it's productive.

Re: Scientists improve anti-tumor power of CAR-T cells

#34

Post by AmericanChopper »

starchild_3001 wrote: post #27
DoreenMichele wrote: post #11

Study after study after study says diet and lifestyle are major factors in every deadly disease. But it's not socially acceptable to suggest that as an approach. However, having already committed the unspeakable sin and egregious faux pas, I will suggest that if cancer is a thing you fret about, you can do something to reduce your risk starting today.

Diet and exercise are universally failed interventions to stop major diseases (CVD, cancer...). People who have a vested interest in them promote them (e.g. exercise specialists, keto experts, vegan gurus, your favorite TV Dr, harvard nutrition dept whose livelihood depends on the effectiveness of "optimal diet" etc), but the results in intervention trials have been extremely disappointing. 1) The best diet studies w…

Diets don’t fail, people fail to follow diets. Which is probably fine in the long run, because they’re always there for people who want them. There’s probably never going to be a wonder drug for obesity though. But Anavar or Trenbolone would work better than Semaglutide, and the side effects likely aren’t that much worse (all of those options are still bad ideas).

Re: Scientists improve anti-tumor power of CAR-T cells

#35

Post by gcanyon »

alexey-salmin wrote: post #30
starchild_3001 wrote: post #27

Earlier quoted context omitted.

Diet and exercise are universally failed interventions to stop major diseases (CVD, cancer...). People who have a vested interest in them promote them (e.g. exercise specialists, keto experts, vegan gurus, your favorite TV Dr, harvard nutrition dept whose livelihood depends on the effectiveness of "optimal diet" etc), but the results in intervention trials have been extremely disappointing. 1) The best diet studies w…

> Exercise is even worse. It has virtually zero effect on CVD outcomes, mortality outcomes in trials where participants were asked to change their behaviors. This is simply not true and you jump through some curious hoops to make it look credible. The paragraph you cite basically says "if you start after 60 it's too late". Is then proceeds to add that a few weeks of exercise are not enough, and a few months of follow…

Healthcare Triage: "To the research!"

https://www.youtube.com/watch?v=hkO44tzkXyQ

https://www.youtube.com/watch?v=SFBBjynBpSw

tl;dw -- the relative risk reduction can be as high as 50%, and depending on risk factors, the absolute risk reduction can be 5%.

Re: Scientists improve anti-tumor power of CAR-T cells

#36

Post by adamredwoods »

askonomm wrote: post #8

I'm 31 which means I got maybe around 20? years before I become a prime target of potential cancers. I really hope by then most of even today's abilities are at least available in most hospitals, since right now cancer treatment in Estonia is still old-school chemotherapy. Not even sure if our doctors have heard of Car-T. 20 years is probably too little time to make dying from cancer a thing of the past, but maybe ge…

Immunotherapy is the direction we want to go, but Car-T therapy can kill the patient.

Old school chemotherapy still works as a first-line defense, and the newer stuff is getting better (paclitaxel, antibody drug conjugates (ADC)).

Re: Scientists improve anti-tumor power of CAR-T cells

#38

Post by eternal_braid »

JoshTriplett wrote: post #21
askonomm wrote: post #10

Earlier quoted context omitted.

Our hearts would eventually give out anyway. I'd just much rather die of a sudden heart attack than a long and torturous cancer battle.

> Our hearts would eventually give out anyway. We need to fix that too.

At some point, it is good to die, to make room for the next generation, no matter how great you are. Others deserve a shot, too.

Re: Scientists improve anti-tumor power of CAR-T cells

#39

Post by JoshTriplett »

eternal_braid wrote: post #38
JoshTriplett wrote: post #21

Earlier quoted context omitted.

> Our hearts would eventually give out anyway. We need to fix that too.

At some point, it is good to die, to make room for the next generation, no matter how great you are. Others deserve a shot, too.

No. Nothing is worth the utter destruction of a person. People have an endless capacity to learn and grow, and there is no limited room for people that's getting used up; the universe is a very big place. Longevity will certainly lead to some interesting challenges; bring them on, they're worth solving and none of them are worth killing people to avoid. And preventing people from living is absolutely equivalent to killing them.

Re: Scientists improve anti-tumor power of CAR-T cells

#40

Post by gwd »

AmericanChopper wrote: post #34
starchild_3001 wrote: post #27

Earlier quoted context omitted.

Diet and exercise are universally failed interventions to stop major diseases (CVD, cancer...). People who have a vested interest in them promote them (e.g. exercise specialists, keto experts, vegan gurus, your favorite TV Dr, harvard nutrition dept whose livelihood depends on the effectiveness of "optimal diet" etc), but the results in intervention trials have been extremely disappointing. 1) The best diet studies w…

Diets don’t fail, people fail to follow diets. Which is probably fine in the long run, because they’re always there for people who want them. There’s probably never going to be a wonder drug for obesity though. But Anavar or Trenbolone would work better than Semaglutide, and the side effects likely aren’t that much worse (all of those options are still bad ideas).

> Diets don’t fail, people fail to follow diets.

That's like saying, "Exhortations to developers not to write bugs don't fail, programmers fail to follow exhortations." Guess what? Even the most skilled and well-intentioned programmers will write bugs, despite their best efforts; and lots of programmers simply won't put out their best efforts. If your goal is simply to find someone to blame, then sure, blame the developers. But if your goal is better software, exhortations not to write bugs are simply an ineffective intervention. You need to introduce other measures, like type systems, linters, static checkers, code reviews, and testing.

Similarly, if people consistently fail to follow diets, then the current crop of diets are an ineffective intervention. If your goal is to assign blame, then sure, you can stop there and feel good that you've found someone to blame. But if your goal is to actually make the situation better, then you need to find something else.

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