FDA approves multiple generics of ADHD and BED treatment Vyvanse • Hacker News Board

Re: FDA approves multiple generics of ADHD and BED treatment Vyvanse

#41

Post by TheHumanist » Thu, Aug 31, 2023, 10:23 AM UTC

irdc wrote: post #34

petesergeant wrote: post #17

Earlier quoted context omitted.

Don’t people acclimatise to them? Biggest reason I don’t take Vyanse is because I’m worried it’ll stop working (like modafinil did) but leave me addicted to it

Sure, you're going to feel like crap for a week or so if you stop Vyvanse after taking it for a while (I know I did). But since a therapeutical dose is nowhere near a recreational one, the risk of developing a craving for it (which is really what addiction is all about) is low. Heck, I've had more problems weaning myself off of diclofenac.

Long part of my life on Adderall and decent amount on Vyvanse at one point and never noticed any actual addictive cravings, like you mention.

Sure, when I stop I feel kinda crappy... But... I'm not on a stimulant that I had been on. I'm just not as 'up'. Not as focused. Etc. Never any actual withdrawals or cravings for either though. Gets very tiring how many people that probably never have regularly used either like to pull out their megaphones and yell about how they are addictive.

Why don't we worry about ultra processed foods, high sugar intake... Things like that that are actually a problem for a LOT of people? People focus on the oddest things.

Re: FDA approves multiple generics of ADHD and BED treatment Vyvanse

#42

Post by lnxg33k1 » Thu, Aug 31, 2023, 10:23 AM UTC

zolland wrote: post #33

tux3 wrote: post #8

Earlier quoted context omitted.

You'll be happy to know it does work great. Contrary to popular belief, giving stimulants significantly reduces the risks of addiction, alcoholism, substance abuse, etc. You have to treat people, otherwise they try to get their dopamine sonewhere else. Whether that's binge eating, or worse.

I think to an extent this is essentially just redirecting the preexisting addiction (edit: remove issues) onto a drug that simply produces normative behavior, specifically behavior that conforms with modern society's idea of a highly productive and obedient individual. For those that aren't already addicted to something, say those with adhd, I wonder to what extent their environment is causing the issues that they se…

Well I am all for legalisation in general, but replacing illegal drugs with legal drugs other than doing something that is acceptable for the society, being the illegal drugs non-accepted, it would also mean that you aren't going to fund drug cartels, ghettos, traffickers, or in general you're not going to end up in a morgue with fentanyl, so for me, in modern context, that's still a big win

Re: FDA approves multiple generics of ADHD and BED treatment Vyvanse

#43

Post by TheHumanist » Thu, Aug 31, 2023, 10:26 AM UTC

firstplacelast wrote: post #12

numbers_guy wrote: post #10

Earlier quoted context omitted.

Those working environments already exist, but maybe you are not interested in them. People with ADHD are advised to do jobs that require one to be on their feet. Sitting behind a desk is unfortunately one of the worst things you can do if you cannot focus easily.

Easier said than done. Outside of sales, what job on your feet pays 200k+/year? Hate sitting at a desk, been diagnosed, and not into sales. Not trying to be combative, would love suggestions. I partly want to go bar-tend or be a plumber, but the wage isn’t there. I should have gone into medicine, but it’s too late for that at this stage.

Favorite job I ever had was managing this small country store gas station when I was like 19-21 years old. Also managing a coffee shop. If I could do one of those and make a real living wage and be able to save for retirement and life stuffs I would do that RIGHT now. But.... That ain't happening. So. I sit at my desk yelling at my code. Man it is so hard to get started each day though. Some days it takes a couple hours to really get going on my actual work. And it isn't for lack of trying. It's so infuriating, wearing, and disheartening.

Re: FDA approves multiple generics of ADHD and BED treatment Vyvanse

#44

Post by TheHumanist » Thu, Aug 31, 2023, 10:28 AM UTC

firstplacelast wrote: post #29

hoagsobject wrote: post #21

Earlier quoted context omitted.

Exactly. Doing all my life software development, since I was kid. I don't have any other skills. I have been considering becoming a cook, or going into the military tho. But it's hard to do when your personality wired around computers, and you have to change it.

I feel it. I’ve been looking at the FBI. It would still be 80% desk work, but better than 100%. Wage is still a step back and I’m nearing the age cut-off, so would have to jump on it pretty soon.

I would love to get in with the CIA. Truly. But I made some bad choices when I was younger so I am disqualified out the gate. Same with FBI.

Re: FDA approves multiple generics of ADHD and BED treatment Vyvanse

#45

Post by TheHumanist » Thu, Aug 31, 2023, 10:28 AM UTC

firstplacelast wrote: post #27

astrange wrote: post #16

Earlier quoted context omitted.

You could get a standing desk.

Have one. Doesn’t solve the problem. I need to move and context switch (ideally).

Running restaurants was GREAT for this but it was the abolute fucking worst ever. Lol

Re: FDA approves multiple generics of ADHD and BED treatment Vyvanse

#46

Post by TheHumanist » Thu, Aug 31, 2023, 10:30 AM UTC

hoagsobject wrote: post #19

gumballindie wrote: post #15

Earlier quoted context omitted.

While being a plumber may not pay much, owning a plumbing company could.

Owning a plumber company does not translate into work on the foot. Probably it will be sitting job

Actually, it does still involve lots of on your feet work. The owner is more often going between current sites to check work that's being done, going to new potential sites to talk with contractors and/or potential customers, etc. Yes, they also are handling the business end but for a plumbing company that doesn't mean you are at a computer all day, there isnt enough atuff for you yo donin that aspext to keep you busy.

Re: FDA approves multiple generics of ADHD and BED treatment Vyvanse

#47

Post by TheHumanist » Thu, Aug 31, 2023, 10:32 AM UTC

gumballindie wrote: post #22

hoagsobject wrote: post #19

Earlier quoted context omitted.

Owning a plumber company does not translate into work on the foot. Probably it will be sitting job

I imagine a high quality plumbing company requires someone inspect the quality of work, discussing with potential clients in person, and other such non desk work. Perhaps even getting one’s own hands “dirty”.

This is what the three people I have known that owned umbing companies did. They had someone they paid to handle a lot of the simple repetitive computer stuff (probably could even automate a lot of that now but I don't think they were people who would have though about that) and they would hop to different current job sites to check on work being done, check in with contractors to make sure work is good and employees are good, go to potential new job sites to meet with contractors or home owners, etc.

Re: FDA approves multiple generics of ADHD and BED treatment Vyvanse

#48

Post by framapotari » Thu, Aug 31, 2023, 10:41 AM UTC

zolland wrote: post #33

tux3 wrote: post #8

Earlier quoted context omitted.

You'll be happy to know it does work great. Contrary to popular belief, giving stimulants significantly reduces the risks of addiction, alcoholism, substance abuse, etc. You have to treat people, otherwise they try to get their dopamine sonewhere else. Whether that's binge eating, or worse.

I think to an extent this is essentially just redirecting the preexisting addiction (edit: remove issues) onto a drug that simply produces normative behavior, specifically behavior that conforms with modern society's idea of a highly productive and obedient individual. For those that aren't already addicted to something, say those with adhd, I wonder to what extent their environment is causing the issues that they se…

Without medication, I feel much less in control of my mind. It's like I'm in a mind-fog; every long-term thought is blurry and vague so everything tends to become about the short-term. I know that eating this sugary garbage is bad for me but the immediate dopamine gratification massively outweighs that knowledge. Same with tasks I know I need to complete. I know that doing them is the correct thing to do and that procrastinating on them will not be beneficial for me overall, but I just can't "see" that future in my mind.

I don't think this is caused by my environment. Feeling like you are unable to think a clear thought is not because clear thoughts conform with modern society's ideas of a highly productive an obedient individual. For me it's simply a feeling of not being a whole human. Medication addresses this to a very significant degree, although it's by no means a complete fix.

I also use glasses, and I find similarities there. Without them my eyesight is blurry and I cannot see things beyond a very short distance. Are glasses simply producing normative behavior that conforms with modern society's idea of a highly productive and obedient individual? Is it really the environment that is causing me to think of bad eyesight as an issue to be addressed? Obviously not; being able to see clearly is something you want regardless of environment. I think that the same applies to being able to think clearly.

Re: FDA approves multiple generics of ADHD and BED treatment Vyvanse

#49

Post by hombre_fatal » Thu, Aug 31, 2023, 10:44 AM UTC

CommitSyn wrote: post #5

toomuchtodo wrote: post #2

> FDA has approved several first generics of Vyvanse (lisdexamfetamine dimesylate) capsules and chewable tablets for attention-deficit/hyperactivity disorder (ADHD) in patients six years and older and moderate to severe binge-eating disorder (BED) in adults. See Vyvanse’s prescribing information for details on dosing.

Giving an addictive stimulant to food addicts That'll work greeeeat. Then again if I remember correctly, Vyvanse isn't something you can get a continual high from like traditional amphetamines. : I may be completely mis-renembering that.

Vyvanse is basically the same thing as normal extended release amphetamine except it lasts longer with a gentler up down curve.

So you can abuse it the same way. It just lasts longer.

The continual high you can get on a large dose is the same, just less peaky.

> Giving an addictive stimulant to food addicts

Yeah, amphetamine has so many effects beyond appetite suppression that it’s a pretty blunt instrument for that. GLP1 agonists like Ozempic seem far more promising since they don’t have the ability to crack you out.

Re: FDA approves multiple generics of ADHD and BED treatment Vyvanse

#50

Post by hombre_fatal » Thu, Aug 31, 2023, 10:57 AM UTC

irdc wrote: post #11

CommitSyn wrote: post #5

Earlier quoted context omitted.

Giving an addictive stimulant to food addicts That'll work greeeeat. Then again if I remember correctly, Vyvanse isn't something you can get a continual high from like traditional amphetamines. : I may be completely mis-renembering that.

The danger of pharmaceutical-grade amphetamines at therapeutic doses is vastly overstated. It’s not like it’s alcohol (carcinogenic) or sugar.

I don’t think it’s overstated. It’s just one of those things where some people can’t handle it and end up in a serious downward spiral but others stick to therapeutic use that positively changes their whole life, so the latter group always has to prove they’re not in the former group.

Everyone I knew in uni was on Adderall XR and some people overdid it, like making these crazy manic posts on Facebook and staying cracked out for days on a train of big redoses. There are real risks.

And because of that, any time I go to a new doctor, I have to deal with them side eyeing me as I try to prove to them I’m not just a pill seeking junkie even though I’ve been taking it for 15 years. It can be so dehumanizing, like I’m a child of a parent that goes to see if I really did clean my room like I said I did.