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Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

moorfields.nhs.uk

131–137 of 137 posts

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#131
I must mention that I wrote the article titled “Opportunistic detection of type 2 diabetes using deep learning from frontal chest radiographs” (you can find it here: https://www.nature.com/articles/s41467-023-39631-x). While many of these models present promising advantages for population health, there are still many challenges related to bias and execution. However, it’s worth noting that early disease detection can provide benefits, not necessarily cures. The IDEAs study is a good example of this in Alzheimer’s disease.

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#132
post #35

Earlier quoted context omitted.

If nothing else, it could allow you to make different decisions in your life. If my mind is going to be gone in 10 years, I'm sure as shit not saving for long term retirement anymore.

> If my mind is going to be gone in 10 years, I'm sure as shit not saving for long term retirement anymore. But hopefully if you could get a Parkinson's diagnosis seven years prior to symptoms, you'd be able to save some money to keep from becoming a burden on your family later on.

There's other ways to avoid becoming a burden, but yes that would be worth planning for.

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#133

Earlier quoted context omitted.

We have all have something incurable in the future. It’s called death. Do you dread the time ahead of you?

I do.

Well if your already dread the time ahead of you then you might as well know, it can't get much worse eh?

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#134
post #86
post #63

> Using a type of AI known as ‘machine learning’, computers are now able to uncover hidden information about the whole body from these images alone. So now computers use AI to do something, interesting... I always liked how it's always "AI did X" or "AI discovered Y", but never a "crane built a building".

Odd statement, as it is of course always the thinker that gets the attribution, i.e. the manipulator of tools and the interpreter of results. E.g.1: Galileo saw Jupiter , not The telescope saw Jupiter . E.g.2: Joe built the wall , not The crane built the wall . In this case, AI is the thinker, not a human, hence the phrasing. A human creating the AI does not remove the attribution either, just as we never say Joe's m…

> AI is the thinker

As an AI specialist, I strongly object that statement. There's usually very little surprise in what "AI has discovered", usually we spend months of hard work to make it discover that one thing. But all the credit goes to "AI" :)

PS: I'm yet to see an AI (in any area) that's the thinker.

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#135
post #92

Earlier quoted context omitted.

https://www.statista.com/statistics/205758/net-sales-of-dick... Not seeing much customer hemorrhaging in that graph.

Surprising if true. How do you dig yourself into a $250 million hole with ever increasing net sales?

Your expenditures beat your income.

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#137

Earlier quoted context omitted.

What does early intervention look like for Parkinson’s besides lifestyle changes?

My mom has Parkinson's and was in the medical industry for many years (so is a reasonably savvy person). So I trust her opinion, and have been helping her manage the disease. There is effectively nothing at this point that appears to stop the progression of the disease besides lifestyle changes. My mother at 70 goes to the gym for about 2 hours a day on average. This is the most obviously helpful. She has tried fecal…

That's awesome. It's not easy to get seniors to spend that much time in the gym, so well done if you contributed to motivate her! Physical exercise is indeed one of the few Parkinson's treatments that there's little doubt about.

In terms of reversing the damage, look into photobiomodulation (PBM) aka red light therapy. In "Improvements in clinical signs of Parkinson's disease", Liebert et al in 2021, she shows improvement in all symptoms including cognition, which is one of preciously few such results I've found in my extensive search of the literature[1]. Caveats are that this was a proof-of-concept study with n=6 only and that the red light helmet is somewhat expensive if you want to try it. There's a Canadian company that makes one for above $2000 (modern, very sci-fi thing), and a more hackerish version from an Australian company for ~$700 (pairs of diodes on aluminum bands you have to finish assembling yourself).

[1]: At least which are actionable for the public. There are tons of trials but good luck getting in early unless you can donate a new library to the university! Gene therapy, stem cell therapy, GDNF, drugs that target alpha-synuclein are all promising but not yet accessible. PBM is something you can do today and since mitochondrial dysfunction is a leading hypothesis in the pathogenesis of PD, the treatment fits.

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