Live data from Hacker News

Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

moorfields.nhs.uk

71–80 of 137 posts

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#71
post #2

We already carry a highly sophisticated camera in our pockets. How long before we can leverage a smart phone to become the tricorder Star Trek had always promised? Apple Watch looks to be promising, and I imagine a world where humans won’t have to visit a doctor for a diagnosis, but rather to confirm, and walk a patient through a successful treatment plan

For the developing world, this is likely a great option [1] [2] (although you need to account for additional optics for a smartphone ["fundus camera"]). For the developed world, it's likely this gets lumped into a traditional eye exam. The benefit is from squeezing more data out of existing imaging encounters using ML; think about these as data pipeline implementations. > High-resolution images of the retina are now…

I don’t see an iPhone or similar device getting OCT-like images anytime soon. They need special optics to image the whole retina (although I can imagine image processing hacks to work around that at the expense of exam speed), but they also require an optical system that’s quite unlike a normal camera to acquire an image at all.

I think the real issue with OCT cost is machine utilization. An OCT machine is cheap as medical devices go, but, in the usual US model, it gets extremely low utilization. It takes a minute or so to get a scan, it’s completely painless and requires neither dilation or any particular expertise, but the machines only get used a couple times a day.

A venue like Costco or a comparably busy place in a different country could probably offer walk-up OCT scanning for a couple dollars or maybe even free and encourage people to do it once per year. If the FDA played along, software could likely analyze the images and detect the progression of quite a few diseases, several of which would be treatable.

(A brand new machine seems to cost something like $20k. If it gets used 60 times per day (credible for a large scale user but not for a small shop), $1 of revenue per scan gives an adequate payback.)

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#72
post #20

The idea of knowing you're going to get dementia sometime in the next decade is interesting. But I don't think it's straight-forward as to whether or not knowing is a good idea. It's also a little amusing to take the idea to its logical extreme: What if it becomes a societal norm to know? Would public venues allow soon-to-be dementia patients line cutting priority etc? Think amusement parks, transit reservations, hot…

Knowing you will have something incurable has only downsides. You will dread the time ahead of you instead of enjoying your present time.

I'd definitely take a different career/life path if I knew I had a few years left. Being able to predict the future has implications on actions.

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#73

The idea of knowing you're going to get dementia sometime in the next decade is interesting. But I don't think it's straight-forward as to whether or not knowing is a good idea. It's also a little amusing to take the idea to its logical extreme: What if it becomes a societal norm to know? Would public venues allow soon-to-be dementia patients line cutting priority etc? Think amusement parks, transit reservations, hot…

We could spend our remaining days living it up, but after we're dead all those experiences won't make one whit of difference to us. What will live on is our legacy, in the minds of those still living. I'd rather not be remembered as someone who pushed others aside and spent their inheritances. Something to think about.

> What will live on is our legacy, in the minds of those still living.

For two or three generations, that is, with very few notable exceptions.

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#74

I recall two companies working on this - RightEye and Neuralight: https://techcrunch.com/2018/02/17/righteyes-portable-eye-tra... https://techcrunch.com/2022/05/24/neuralight-aims-to-track-a... Probably there are more by now. As I recall this data is great for essentially saying "you should go get a real test." No one is diagnosing - just saying that a certain, say, eye movement slowness is correlated and you can det…

[flagged]

> Sometimes companies do good stuff!

Obviously. Otherwise they wouldn't get paid for very long.

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#75
post #67

Earlier quoted context omitted.

> If my mind is going to be gone in 10 years Parkinsons affects motor control, not mental functioning. The point still stands -- if I got a diagnosis I would be less likely to embark on learning to play the piano, and I'd start educating myself on the disease. EDIT: I'll correct myself. It primarily affects motor control, but late in the disease it can affect cognition.

Every case is different , but Parkinson’s is often associated with severe dementia that can manifest fairly quickly. I saw this happen to a close family member unfortunately.

My friend's grandmother's hand started shaking badly eating soup and she got bedridden due to a fall in their home, 1 year later she started calling her daughter "nurse" because she didn't recognize her and passed away not too long after due to heart failure. I really hope they will find a treatment to this disease eventually.

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#76

Earlier quoted context omitted.

If it’s predictable you’ll fail, that’s not insurance. Insurance is about unpredictable failures. It may sound odd, but it’s the nature of it.

Coverage or cost sharing then

Maybe but the cost is already high even when you exclude those who deliberately drive it up.

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#78
post #20

Earlier quoted context omitted.

Knowing you will have something incurable has only downsides. You will dread the time ahead of you instead of enjoying your present time.

We have all have something incurable in the future. It’s called death. Do you dread the time ahead of you?

I do.

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#79

The idea of knowing you're going to get dementia sometime in the next decade is interesting. But I don't think it's straight-forward as to whether or not knowing is a good idea. It's also a little amusing to take the idea to its logical extreme: What if it becomes a societal norm to know? Would public venues allow soon-to-be dementia patients line cutting priority etc? Think amusement parks, transit reservations, hot…

If it allows you to prepare and get your affairs in order to better deal with it as it brings your life to a halt, then it's a great thing.

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#80

Earlier quoted context omitted.

[flagged]

> Sometimes companies do good stuff! Obviously. Otherwise they wouldn't get paid for very long.

That's not necessarily true. Major US corporations like DICK's are all aboard the woke train despite hemorrhaging customers massively from the second and third order consequences of banning scary things from their stores several years ago. To the tune of $250 million. And the CEO kept his job!
Post reply on HN