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Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

moorfields.nhs.uk

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Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#2
We already carry a highly sophisticated camera in our pockets.

How long before we can leverage a smart phone to become the tricorder Star Trek had always promised?

Apple Watch looks to be promising, and I imagine a world where humans won’t have to visit a doctor for a diagnosis, but rather to confirm, and walk a patient through a successful treatment plan

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#4
post #2

We already carry a highly sophisticated camera in our pockets. How long before we can leverage a smart phone to become the tricorder Star Trek had always promised? Apple Watch looks to be promising, and I imagine a world where humans won’t have to visit a doctor for a diagnosis, but rather to confirm, and walk a patient through a successful treatment plan

Expect doctors and the related industries and bodies like the useless FDA to fight hard against that. As usual.

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#5
post #2

We already carry a highly sophisticated camera in our pockets. How long before we can leverage a smart phone to become the tricorder Star Trek had always promised? Apple Watch looks to be promising, and I imagine a world where humans won’t have to visit a doctor for a diagnosis, but rather to confirm, and walk a patient through a successful treatment plan

Google has worked on using smartphones for: measuring heart rate, identifying skin conditions, detecting disease through pictures of the eye, and as a type of stethoscope: https://ai.googleblog.com/2023/02/google-research-2022-beyon...

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#6
post #4
post #2

We already carry a highly sophisticated camera in our pockets. How long before we can leverage a smart phone to become the tricorder Star Trek had always promised? Apple Watch looks to be promising, and I imagine a world where humans won’t have to visit a doctor for a diagnosis, but rather to confirm, and walk a patient through a successful treatment plan

Expect doctors and the related industries and bodies like the useless FDA to fight hard against that. As usual.

They already do. Any time you start talking about wanting to do exploratory analysis for preventative reasons they’ll react in some way like “Hurr hurr whoa there buddy, you don’t want to get yourself anxious over benign stuff! This will do more harm than good!”

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#7
post #2

We already carry a highly sophisticated camera in our pockets. How long before we can leverage a smart phone to become the tricorder Star Trek had always promised? Apple Watch looks to be promising, and I imagine a world where humans won’t have to visit a doctor for a diagnosis, but rather to confirm, and walk a patient through a successful treatment plan

For the developing world, this is likely a great option [1] [2] (although you need to account for additional optics for a smartphone ["fundus camera"]). For the developed world, it's likely this gets lumped into a traditional eye exam. The benefit is from squeezing more data out of existing imaging encounters using ML; think about these as data pipeline implementations.

> High-resolution images of the retina are now a routine part of eye care – in particular, a type of 3D scan known as ‘optical coherence tomography’ (OCT), which is widely used in eye clinics and high-street opticians. In less than a minute, an OCT scan produces a cross-section of the retina (the back of the eye) in incredible detail – down to a thousandth of a millimetre.

[1] https://www.cureus.com/articles/106024-effective-low-cost-op...

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609317/

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#8
post #3

I've read that because Parkinson's is caused by the death of dopaminergic neurons in the brain, the same process could be affecting dopaminergic cells in the eye, which do exist. This might be what they're seeing. Thoughts?

"I've read that because Parkinson's is caused by the death of dopaminergic neurons in the brain"

Not to nitpick, but it's my understanding that we all lose dopaminergic neurons in the Substantia Nigra as we get older. Some people lose them a a lot faster, and they develop what we call "Parkinsons". There is also presence of Alpha Synuclein in the dysfunctional dopaminergic neurons, which are not generally present in the "non-parkinsons" population...

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#9
post #6
post #4

Earlier quoted context omitted.

Expect doctors and the related industries and bodies like the useless FDA to fight hard against that. As usual.

They already do. Any time you start talking about wanting to do exploratory analysis for preventative reasons they’ll react in some way like “Hurr hurr whoa there buddy, you don’t want to get yourself anxious over benign stuff! This will do more harm than good!”

People Googling their symptoms and treatments undoubtedly does cause anxiety and correcting mistaken impressions does cost clinical time. There is a middle road here somewhere - we just have to find it, or accept the costs that come with having more tools.

Re: Eye scans detect signs of Parkinson’s disease up to seven years before diagnosis

#10
post #2

We already carry a highly sophisticated camera in our pockets. How long before we can leverage a smart phone to become the tricorder Star Trek had always promised? Apple Watch looks to be promising, and I imagine a world where humans won’t have to visit a doctor for a diagnosis, but rather to confirm, and walk a patient through a successful treatment plan

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