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A protein that disrupts cells’ energy centers may be a culprit in CFS/ME

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Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME

#191

Post by [deleted] »

atv123 wrote: post #190
quenched wrote: post #177

Earlier quoted context omitted.

There is no evidence for functional neurological disorder, it is simply a hypothesis. As a diagnostic category it is essentially a "god of the gaps" construct. Remember also that the name is a re-branding of what used to be called conversion disorder (previously known as hysteria), that was found to be an acceptable term to patients.[1] It's heavily published on and widely accepted as valid by neurologists, but that…

Said by no neurologist ever... This reflects a complete lack of understanding of the diagnostic criteria. FND is not just a diagnosis made when it doesn't fit anything else. If you actually understood the diagnosis and still felt like it was BS for some reason, it would be because you would be arguing that patients are intentionally feigning their symptoms rather than "the diagnosis just does not exist at all" or tha…

[deleted]

Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME

#192

Post by manmal »

InSteady wrote: post #75
treprinum wrote: post #22

Earlier quoted context omitted.

Wouldn't large quantities of glutamine daily (30g+) be the best way to reduce gut permeability?

This has been found to be effective, although it has a huge list of potential side effects [0]. Anecdotally, among people with GI problems, especially IBS, it can often cause reactions such as nausea, anxiety, and bloating (some practitioners estimate this to occur in about 30% of patients). For this reason it is often recommended to start in small doses (3-5g), sometimes split throughout the day, and gradually incre…

Betaine also has some interesting studies around mitigating intestinal permeability, among lots of other things.

Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME

#193

Post by philjohn »

hotdogscout wrote: post #20

I got long covid in Jan 2022 but after 9 months the neurological symptoms went away. I got sick just this week and the brain fog came back. Taking probiotics and supplements (omega 3, Multivitamins) and aspirin accelerates the process of getting better for me. I use n-back exercises from Brain Age Concentration Training as measure.

Interesting, as aspirin is an anti-inflammatory - there's also a super small scale trial that happened in Madrid where a short course of 30mg of predisone had positive impact on those suffering from long-covid.

Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME

#194

Post by vaelin »

joshjhargreaves wrote: post #113

All I can say is that having significant gut dysbiosis is enough to have significant fatigue - think for sure, you can end up having fatigue from cell energy production issues, but it's clear to me that there are definitely different causes of CFS.

It's possibly the same thing. Endoplasmic Reticulum Stress, the type of stress which may cause this protein to become elevated, was induced in mice by exposing them to endotoxin, a type of toxin produced in the gut.

So gut dysbiosis may trigger this very mechanism.

Re: A protein that disrupts cells’ energy centers may be a culprit in CFS/ME

#195

Post by naasking »

htss2013 wrote: post #178
Aurornis wrote: post #162

Earlier quoted context omitted.

50K IU of Vitamin D per week would push many people into overdose range after a few months. Anyone taking high doses like this needs to also get blood tests to make sure they're not accumulating too much. Remember that it stays in the body a long time and therefore overdose can take many months or over a year to finally show up. Vitamin D only really has dramatic effects in people who are severely deficient. Despite…

I wish this was true but I and other family members had rock bottom low vitamin D levels in lab tests. We supplemented until it rose to normal levels. None of us noticed any perceptible difference. Suppodedly this will prevent problems but it doesn't feel like anything has been fixed. I wonder how much is placebo.

Vitamin D is essential for strong bones. You'd probably only feel it with age when you develop osteoporosis
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