Totally agree. My journey started with TMJ disorder. Turns out bruxism (teeth grinding) is common in sleep apnea patients; I assume because it forces the lower jaw forward. I started with a mandibular advancement device and it was amazing. It completely relived my debilitating TMJ jaw pain and fixed my sleep apnea. I couldn’t believe how amazing I fet every morning. Unfortunately, and which was clearly communicated t…
Can you elaborate on “oral small molecule”? Googles failed me.
Flipping the model presents a new way to treat sleep apnoea
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Re: Flipping the model presents a new way to treat sleep apnoea
#22Earlier quoted context omitted.
Can you elaborate on “oral small molecule”? Googles failed me.
https://apnimed.com/ https://journals.lww.com/neurotodayonline/Fulltext/2022/0407...
Thanks.
“AD109 targets two neurochemical pathways which control the upper airway musculature during sleep via a dual mechanism of action”
Re: Flipping the model presents a new way to treat sleep apnoea
#23Earlier quoted context omitted.
Is it really difficult to understand why people don't like sleeping with a mask that makes noise?
If you are asleep, can you hear it?
Your partner hears it, you may hear it when it has moved a bit and the air is leaking, you hear it when you try to go to sleep and the overpressure safety valve is next to your pillow and making a wheezing sound, when you end your sleep cycle and could go to another one except that the mask moved a little and it's bothering enough to wake you up (and then you have to find sleep again), you worry about keeping it and yourself in just the right position that will allow you to go back to sleep, effectively preventing you from falling asleep because of the stress...
And I have a few reasons more,if you really need.
Re: Flipping the model presents a new way to treat sleep apnoea
#24The number of people that are using a CPAP is honestly mind boggling to me. The number that have gotten one, and then refuse to wear it is even crazier. I remember when I first got one, I assumed it was some niche thing that was going to be unheard of from everyone I talked to. Turns out, not so much. I don't think it has been a miracle device, by any measure. But I'm curious what makes it so hard to stick to for so…
Not as mind boggling as the obesity rate.
I’m very aggressive towards friends about cpaps. I bother them until they do a sleep study. It is life changing for many of us.
Re: Flipping the model presents a new way to treat sleep apnoea
#25The number of people that are using a CPAP is honestly mind boggling to me. The number that have gotten one, and then refuse to wear it is even crazier. I remember when I first got one, I assumed it was some niche thing that was going to be unheard of from everyone I talked to. Turns out, not so much. I don't think it has been a miracle device, by any measure. But I'm curious what makes it so hard to stick to for so…
When I wear it I wake up in the middle of the night and feel like I am suffocating. Like it’s smothering me in my sleep. Even the expensive biPAP makes me feel this way. I have no such issues when I sleep without one.
Re: Flipping the model presents a new way to treat sleep apnoea
#26Totally agree. My journey started with TMJ disorder. Turns out bruxism (teeth grinding) is common in sleep apnea patients; I assume because it forces the lower jaw forward. I started with a mandibular advancement device and it was amazing. It completely relived my debilitating TMJ jaw pain and fixed my sleep apnea. I couldn’t believe how amazing I fet every morning. Unfortunately, and which was clearly communicated t…
> I love my nasal pillows plus chin strap CPAP
Speaking of chin straps - I could never get one to work, but “Caldera Releaf Neck rest” collar worked a treat.
Re: Flipping the model presents a new way to treat sleep apnoea
#27Has anyone used an oral appliance off the market? I googled and found this thing called snoreRx. Any recommendations or reviews? I would prefer to just go get something like this which I can pay for directly rather than have to navigate insurance etc. so if there's a DTC brand that has worked for someone that would be a great plus.
From the discussion with my doctor and dentist, I ended having both the cpap for home usage and the dental appliance, made by the dentist, for when I'm sleeping elsewhere. In my case (just above mild apnea), sleep is incredibly better with the cpap, and mildly better with the dental appliance,so the second one is good for temporary measures. And I resent forgetting it when it happens, as a week of poor sleep really affects my behavior.
Re: Flipping the model presents a new way to treat sleep apnoea
#28...i may be stupid but i could have sworn endotyping was already a thing. i talked to someone last week who brought it up. does anyone w more expertise know what the specific innovation is?
I was curious about the term, too. I found this [1], although it focused on asthma. I found it interesting, and the money quote is ”The term asthma is now considered an umbrella diagnosis for several diseases with distinct mechanistic pathways (endotypes) and variable clinical presentations (phenotypes)."
Re: Flipping the model presents a new way to treat sleep apnoea
#29The number of people that are using a CPAP is honestly mind boggling to me. The number that have gotten one, and then refuse to wear it is even crazier. I remember when I first got one, I assumed it was some niche thing that was going to be unheard of from everyone I talked to. Turns out, not so much. I don't think it has been a miracle device, by any measure. But I'm curious what makes it so hard to stick to for so…
Is it really difficult to understand why people don't like sleeping with a mask that makes noise?
My swift pillow on a Resmed A10 is 0db. I can’t tell if it’s running sometimes. It’s not for everybody but people should expect to have to experiment for a few weeks.
Re: Flipping the model presents a new way to treat sleep apnoea
#30Totally agree. My journey started with TMJ disorder. Turns out bruxism (teeth grinding) is common in sleep apnea patients; I assume because it forces the lower jaw forward. I started with a mandibular advancement device and it was amazing. It completely relived my debilitating TMJ jaw pain and fixed my sleep apnea. I couldn’t believe how amazing I fet every morning. Unfortunately, and which was clearly communicated t…
>What has made a major impact was seeing an ENT [...] Turns out “negative pressure” is a major cause of airway collapse.
The cause of snoring & apnea, from my own searching online and seeing various anecdata, is that there are several common causes but it can vary wildly.
I've also tried many similar treatments to yours, short of CPAP, and including trying tongue & jaw exercises and mewing to try and get my default sleeping jaw & tongue position to be the same as when I'm awake (never had success after months). I had my deviated septum corrected and a turbinectomy alongside it, and it made absolutely no difference to my snoring (but I do breathe better in more humid climates now).
The only other main factor I've noticed is weight, or rather visceral fat. Being overweight often comes with lots of visceral fat, and this includes near the airways, thus constricting the space your airways have to operate with. Perhaps that contributes to this whole negative pressure thing.
A side benefit of having your partner sleep separately is that there is far less sleep disturbance, even the kinds you wouldn't notice. My sleep quality has gone up.