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FDA Approves First Oral Treatment for Postpartum Depression

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Re: FDA Approves First Oral Treatment for Postpartum Depression

#181

Post by psychphysic »

rabbits_2002 wrote: post #5
01100011 wrote: post #3

https://en.wikipedia.org/wiki/Zuranolone "An orally active inhibitory pregnane neurosteroid, zuranolone acts as a positive allosteric modulator of the GABAA receptor." Interesting. I was expecting another SSRI or something similar.

“positive allosteric modulator of the GABAA receptor”, isn’t that a benzodiazepine? edit: nevermind i guess drugs are classified by their chemistry rather than their effects

Technically it's a Z-drug (like Zolpidem/Ambien) which are non-benzodiazapine positive allosteric modulators of GABA_A

However, since it's a neurosteroid most will probably not think of it as such. (It's name does begin with Z though... And end in -one like a steroid).

Anyways, it's licensed for 2 weeks only, side effects are drowsiness, sleepiness and cognitive impairment. You mustn't drive within 12 hours of a dose.

It's best effects are where the depression is associated with insomnia and anxiety.

It was compared to placebo not Alprazolam (Xanax) which has some antidepressant activity.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#182

Post by gillytech »

maxbond wrote: post #79
gillytech wrote: post #71

Earlier quoted context omitted.

[flagged]

You've failed to demonstrate that this is authoritarian. And I haven't criticized you for criticizing the FDA. I've criticized you for defending your position with misinformation, and for deploying marginalized people as a smokescreen. If your best rebuttal is to put words in my mouth and frame my criticism as censorious, it's time to reevaluate. It's a form of motte-and-bailey argument, you've abandoned your positio…

Marginalized people? What are you talking about? The first cases of AIDS was identified in homosexuals. That's a fact.

My position is not that there have been no breakthroughs in the treatment of HIV at all. My argument is that HIV does not cause AIDS.

When you don't have empirical evidence to support your fake claim that HIV causes aids then yeah, you need to go authoritarian. Hence endless government and para-government agencies dictating truth through biased and hopelessly flawed studies.

When your argument is built on BS you need to argue at the upper levels and never look at the foundation.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#183

Post by psychphysic »

Technically it's a Z-drug (like Zolpidem/Ambien) which are non-benzodiazapine positive allosteric modulators of GABA_A

However, since it's a neurosteroid most will probably not think of it as such. (It's name does begin with Z though... And end in -one like a steroid).

Anyways, it's licensed for 2 weeks only, side effects are drowsiness, sleepiness and cognitive impairment. You mustn't drive within 12 hours of a dose.

It's best effects are where the depression is associated with insomnia and anxiety.

It was compared to placebo not Alprazolam (Xanax) which has some antidepressant activity.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#184

Post by oblio »

speff wrote: post #87
MarkMarine wrote: post #74

Earlier quoted context omitted.

If you think this is a risk, have a plan for it, and not just for her. For you as well. The knock on effects of trying to do everything for the newborn, manage your partner’s symptoms and help in their treatment, and try to sleep while furiously doing laundry, cooking, scrubbing bottles, etc… you need support. You need people staying with you 24/7, people that aren’t on some vacation with a couple photo ops with the…

That's really kind advice - I appreciate it. Luckily the folks pretty close-by, but you spelling all of that out really changes my perspective how hard it'll be. We got a young puppy a year back now which seemed like good practice - with the lack of sleep, constant attention, constant pooping/peeing. But yea, a baby's absolutely going to be another level's worth of difficult.

Personal experience, I don't know if it's backed by studies. We think that there are a bunch of factors you can control that help reduce the risk, you probably know them:

* sleep deprivation: take turns taking care of the baby and let the mom sleep whenever she can, naps during the day, when the baby is napping, when the baby is with you, etc; getting as much sleep is > for the mom

* moral support: no matter how much things suck, you're in this together; talk to the mom and ideally, make fun of the literally shitty situation :-)

* as mentioned by others, get more help if you can; no shame in doing it, you said you were a military man, wouldn't you want to greatly outnumber "the enemy" (the baby)? :-p

* take the longest leave possible, don't save PTO; you're probably not going anywhere interesting this year, use that time to offer support during this super stressful period.

FYI, statistically the pressure goes down at about 3 months old and again at 6 months old.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#185

Post by tkzed49 »

rs_rs_rs_rs_rs wrote: post #173
aaronbrethorst wrote: post #170

Earlier quoted context omitted.

With all due respect, fuck off. How dare you question my lived experience.

[flagged]

Just some unsolicited advice for you: your comments read as antagonistic and arrogant, and are neither going to get you useful information nor make you any friends. If you're genuinely curious about how this is possible, why not ask good-faith questions about their experience, and then make a judgment quietly to yourself? Instead, you're invalidating them from a position of ignorance. Even in other cases where you might be right, you still look childish and insufferable.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#186

Post by mtlmtlmtlmtl »

NoZebra120vClip wrote: post #163
haldujai wrote: post #156

Earlier quoted context omitted.

It's insane to me that a group of educated and seemingly intelligent people seem to think they understand more about drug safety and prescribing than the FDA, researchers and physicians. This is reminiscent of the Texas district judge who decided to controversially overrule the FDA on a medication safety decision that recently made the news, not good company one wants to have and I'm hoping is coincidental than sugge…

[flagged]

Hey, you know what causes suicide more than anything else? Depression. Especially untreated depression. And no, cannabis is not a mental health panacea now matter how many times you claim it is. In fact it generally seems to worsen depression. Never have I been more depressed than when smoking daily. It's nothing but a crutch.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#187

Post by oblio »

aaronbrethorst wrote: post #168

I don't normally like to talk about matters this personal in a forum like this—especially given that I use my real name as my username here, but if it ends up helping one person then I think it'll be worth it. My son was born a little over 9 months ago. He's healthy, delightful, and utterly normal—and yet I, his father, still ended up with postpartum depression. I think it's underreported and under-appreciated that f…

Replies? Are they flagged?

Re: FDA Approves First Oral Treatment for Postpartum Depression

#188

Post by haldujai »

aaronbrethorst wrote: post #168

I don't normally like to talk about matters this personal in a forum like this—especially given that I use my real name as my username here, but if it ends up helping one person then I think it'll be worth it. My son was born a little over 9 months ago. He's healthy, delightful, and utterly normal—and yet I, his father, still ended up with postpartum depression. I think it's underreported and under-appreciated that f…

I'm glad to hear you're feeling great having received treatment and that you're hopefully now getting to enjoy time with your healthy son.

On a personal and professional level I'm greatly appreciative of your decision to share your experience and contribute to the destigmatization and increased awareness of male mental health despite anticipating attacks.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#189

Post by mtlmtlmtlmtl »

warbeforepeace wrote: post #166
mtlmtlmtlmtl wrote: post #147

Earlier quoted context omitted.

Cannabis can also cause fetal harm. And fetal harm is also irrelevant here because this is a treatment for postpartum depression, I.e depression after birth, at which point there is no fetus to be harmed. There's also no credible evidence that cannabis is an efficacious treatment for postpartum depression. But sure, why even bother with science? Just smoke a joint...

What is science and how can i get my neighbor with the trump flag in his yard to learn about it?

I'll get back to you once I've figured out how to stop the ongoing deterioriation of American democracy. Right after getting off the phone with the nobel committee.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#190

Post by aaronbrethorst »

oblio wrote: post #187
aaronbrethorst wrote: post #168

I don't normally like to talk about matters this personal in a forum like this—especially given that I use my real name as my username here, but if it ends up helping one person then I think it'll be worth it. My son was born a little over 9 months ago. He's healthy, delightful, and utterly normal—and yet I, his father, still ended up with postpartum depression. I think it's underreported and under-appreciated that f…

Replies? Are they flagged?

Yes
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