FDA Approves First Oral Treatment for Postpartum Depression
1–10 of 299 posts
Re: FDA Approves First Oral Treatment for Postpartum Depression
#2[flagged]
Re: FDA Approves First Oral Treatment for Postpartum Depression
#3https://en.wikipedia.org/wiki/Zuranolone
"An orally active inhibitory pregnane neurosteroid, zuranolone acts as a positive allosteric modulator of the GABAA receptor."
Interesting. I was expecting another SSRI or something similar.
Re: FDA Approves First Oral Treatment for Postpartum Depression
#4[flagged]
Too late for countless families if you gather all the historical data. That doesn't mean we shouldn't try to curb this.
Re: FDA Approves First Oral Treatment for Postpartum Depression
#5https://en.wikipedia.org/wiki/Zuranolone "An orally active inhibitory pregnane neurosteroid, zuranolone acts as a positive allosteric modulator of the GABAA receptor." Interesting. I was expecting another SSRI or something similar.
“positive allosteric modulator of the GABAA receptor”, isn’t that a benzodiazepine?
edit: nevermind i guess drugs are classified by their chemistry rather than their effects
Re: FDA Approves First Oral Treatment for Postpartum Depression
#6> The primary endpoint of both studies was the change in depressive symptoms using the total score from the 17-item Hamilton depression rating scale (HAMD-17), measured at day 15. Patients in the Zurzuvae groups showed significantly more improvement in their symptoms compared to those in the placebo groups.
Why would you mention the number of items on the scale, but not mention the number of points the drug gained? Is it that professionals normally refer to it as the "17-item Hamilton depression rating scale"?
That they're mentioning the number of points in the scale, but not the number of points gained, makes me wonder if this barely limped into significance under the most favorable conditions.
Re: FDA Approves First Oral Treatment for Postpartum Depression
#7> The primary endpoint of both studies was the change in depressive symptoms using the total score from the 17-item Hamilton depression rating scale (HAMD-17), measured at day 15. Patients in the Zurzuvae groups showed significantly more improvement in their symptoms compared to those in the placebo groups. Why would you mention the number of items on the scale, but not mention the number of points the drug gained? I…
> Why would you mention the number of items on the scale, but not mention the number of points the drug gained? Is it that professionals normally refer to it as the "17-item Hamilton depression rating scale"?
Correct. "17-item Hamilton depression rating scale" (or HAMD-17) is the precise name of the scale; "17-item" is required to distinguish it from other variations with different numbers of questions.
The precise improvement in scoring is undoubtedly present in the clinical trial paper, but isn't relevant to a FDA press release about their approval of the drug.
https://dcf.psychiatry.ufl.edu/files/2011/05/HAMILTON-DEPRES...
Re: FDA Approves First Oral Treatment for Postpartum Depression
#8> The primary endpoint of both studies was the change in depressive symptoms using the total score from the 17-item Hamilton depression rating scale (HAMD-17), measured at day 15. Patients in the Zurzuvae groups showed significantly more improvement in their symptoms compared to those in the placebo groups. Why would you mention the number of items on the scale, but not mention the number of points the drug gained? I…
Looks like about 4 points.
[1] https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/21...
Re: FDA Approves First Oral Treatment for Postpartum Depression
#9> The primary endpoint of both studies was the change in depressive symptoms using the total score from the 17-item Hamilton depression rating scale (HAMD-17), measured at day 15. Patients in the Zurzuvae groups showed significantly more improvement in their symptoms compared to those in the placebo groups. Why would you mention the number of items on the scale, but not mention the number of points the drug gained? I…
> Why would you mention the number of items on the scale, but not mention the number of points the drug gained? Is it that professionals normally refer to it as the "17-item Hamilton depression rating scale"? Correct. "17-item Hamilton depression rating scale" (or HAMD-17) is the precise name of the scale; "17-item" is required to distinguish it from other variations with different numbers of questions. The precise i…
> The precise improvement in scoring is undoubtedly present in the clinical trial paper, but isn't relevant to a FDA press release about their approval of the drug.
Exactly. If it isn’t harmful, it doesn’t have to be very helpful — the effect can be small and significant.
Re: FDA Approves First Oral Treatment for Postpartum Depression
#10https://en.wikipedia.org/wiki/Zuranolone "An orally active inhibitory pregnane neurosteroid, zuranolone acts as a positive allosteric modulator of the GABAA receptor." Interesting. I was expecting another SSRI or something similar.
“positive allosteric modulator of the GABAA receptor”, isn’t that a benzodiazepine? edit: nevermind i guess drugs are classified by their chemistry rather than their effects
Drugs can be variously classified by their chemistry and/or by their effects. It's worth noting that GABA-A receptors have multiple allosteric sites, and different chemical classes of PAMs (positive allosteric modulators) may have differences in effects. (There certainly seems to be substantial overlap in effects, of course.)