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Scientists develop pill able to kill all solid tumors in preclinical research

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Re: Scientists develop pill able to kill all solid tumors in preclinical research

#21

Post by dang »

Oral cancer drug kills 100% of tumors in vitro and in animal models - https://news.ycombinator.com/item?id=37003617 - Aug 2023 (102 comments)

A New Mode of Cancer Treatment - https://news.ycombinator.com/item?id=36982813 - Aug 2023 (208 comments)

New targeted chemotherapy able to kill all solid tumors in preclinical research - https://news.ycombinator.com/item?id=36978199 - Aug 2023 (32 comments)

'Cancer-killing pill' is now being tested on humans - https://news.ycombinator.com/item?id=36969500 - Aug 2023 (31 comments)

Cancer pill AOH1996 shows promise in annihilating all solid tumours - https://news.ycombinator.com/item?id=36960895 - Aug 2023 (20 comments)

Cancer pill AOH1996 shows promise in annihilating all solid tumours - https://news.ycombinator.com/item?id=36960292 - Aug 2023 (16 comments)

Re: Scientists develop pill able to kill all solid tumors in preclinical research

#22

Post by dharmab »

voisin wrote: post #18
dharmab wrote: post #7

Earlier quoted context omitted.

Congress directs the military to fund research for a variety of medical conditions that impact both currently serving and retired military personnel: https://cdmrp.health.mil/researchprograms

Seems bizarre though, no? Why not do this through the NIH or similar group with the deep expertise in this field?

Because the US military has a 243 year history of providing benefits for its war wounded and disabled.

As for "deep expertise" - my father worked for NIH, the VA and a few universities doing basic medical research for about three decades. Usually multiple of those at the same time, sometimes on the same project.

Re: Scientists develop pill able to kill all solid tumors in preclinical research

#24

Post by [deleted] »

sdenton4 wrote: post #14

Neat! Hope it doesn't kill the surrounding cells, too... Sounds like it's meant to single out dividing cells with damaged DNA. But something broad-acting seems more likely to carry unintended consequences. (Eg, if it turns out all liver cells 'look' damaged.) And this is why we have multistage trials.

[deleted]

Re: Scientists develop pill able to kill all solid tumors in preclinical research

#25

Post by voisin »

dharmab wrote: post #22
voisin wrote: post #18

Earlier quoted context omitted.

Seems bizarre though, no? Why not do this through the NIH or similar group with the deep expertise in this field?

Because the US military has a 243 year history of providing benefits for its war wounded and disabled. As for "deep expertise" - my father worked for NIH, the VA and a few universities doing basic medical research for about three decades. Usually multiple of those at the same time, sometimes on the same project.

Providing benefits and developing new treatments seem to differ though, don’t they?

Regarding your father, what was the benefit to him as a researcher to have all of these different groups to work for? Seems like there would be more waste (more fixed overhead of administrators) and bureaucracy.

Re: Scientists develop pill able to kill all solid tumors in preclinical research

#26

Post by dharmab »

voisin wrote: post #25
dharmab wrote: post #22

Earlier quoted context omitted.

Because the US military has a 243 year history of providing benefits for its war wounded and disabled. As for "deep expertise" - my father worked for NIH, the VA and a few universities doing basic medical research for about three decades. Usually multiple of those at the same time, sometimes on the same project.

Providing benefits and developing new treatments seem to differ though, don’t they? Regarding your father, what was the benefit to him as a researcher to have all of these different groups to work for? Seems like there would be more waste (more fixed overhead of administrators) and bureaucracy.

> Providing benefits and developing new treatments seem to differ though, don’t they?

Not at all- many of the health conditions experienced by veterans are service-related, and no private funding is going to fund the basic research. Some of the research is also related to actively serving soldiers. During the Iraq and Afghanistan wars, some of my dad's research was related to keeping soldiers fighting in desert climates hydrated. I also did some work in a VA lab in high school which was researching new prosthetics technologies for victims of IED bombings, which did not leave enough of the persons's limb remaining for existing prosthetic designs to attach to.

> Regarding your father, what was the benefit to him as a researcher to have all of these different groups to work for?

More opportunities for funding! Federal grants are very competitive.

> Seems like there would be more waste (more fixed overhead of administrators) and bureaucracy.

Standard operating procedure when the US government's money is involved.

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