The Cell Chemical Biology study entitled “Small Molecule Targeting of Transcription-Replication Conflict for Selective Chemotherapy” was supported by the Department of Defense Interesting that the DOD supports this kind of research.
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Scientists develop pill able to kill all solid tumors in preclinical research
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Re: Scientists develop pill able to kill all solid tumors in preclinical research
#12Re: Scientists develop pill able to kill all solid tumors in preclinical research
#13The Cell Chemical Biology study entitled “Small Molecule Targeting of Transcription-Replication Conflict for Selective Chemotherapy” was supported by the Department of Defense Interesting that the DOD supports this kind of research.
Between the carcinogens in the water at bases and the fumes from plastic in burn pits, it's not that surprising they'd want to cure cancer. Anyways it's a program administered by the DoD.
Re: Scientists develop pill able to kill all solid tumors in preclinical research
#14Neat! Hope it doesn't kill the surrounding cells, too...
Sounds like it's meant to single out dividing cells with damaged DNA. But something broad-acting seems more likely to carry unintended consequences. (Eg, if it turns out all liver cells 'look' damaged.) And this is why we have multistage trials.
Re: Scientists develop pill able to kill all solid tumors in preclinical research
#15[flagged]
Re: Scientists develop pill able to kill all solid tumors in preclinical research
#16The Cell Chemical Biology study entitled “Small Molecule Targeting of Transcription-Replication Conflict for Selective Chemotherapy” was supported by the Department of Defense Interesting that the DOD supports this kind of research.
Googling "was supported by the Department of Defense" give many interesting results.
This is a good point. Few people are brave enough to search for sentence fragments when they read articles online
Re: Scientists develop pill able to kill all solid tumors in preclinical research
#17Just entering phase I.
> AOH1996 [...] is exclusively licensed by City of Hope to RLL, LLC, a biotechnology company that Malkas co-founded and holds financial interest in...
Re: Scientists develop pill able to kill all solid tumors in preclinical research
#18The Cell Chemical Biology study entitled “Small Molecule Targeting of Transcription-Replication Conflict for Selective Chemotherapy” was supported by the Department of Defense Interesting that the DOD supports this kind of research.
Congress directs the military to fund research for a variety of medical conditions that impact both currently serving and retired military personnel: https://cdmrp.health.mil/researchprograms
Seems bizarre though, no? Why not do this through the NIH or similar group with the deep expertise in this field?
Re: Scientists develop pill able to kill all solid tumors in preclinical research
#19I'm very happy this article keeps popping up on HN, but the tests have been on mice and dogs thus far. More info:
Full:
https://www.cell.com/cell-chemical-biology/fulltext/S2451-94...
Clinical trials:
https://www.cancer.gov/about-cancer/treatment/clinical-trial...
Derek Lowe's response on AOH1996:
https://www.science.org/content/blog-post/new-mode-cancer-tr...
The drug that came before it, AOH1160, but didn't metabolize well:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279569/
Other new, interesting anti-cancer drugs:
https://med.stanford.edu/cancer/about/news/rewiring-cancer-c...
Re: Scientists develop pill able to kill all solid tumors in preclinical research
#20The Cell Chemical Biology study entitled “Small Molecule Targeting of Transcription-Replication Conflict for Selective Chemotherapy” was supported by the Department of Defense Interesting that the DOD supports this kind of research.
You would be surprised. The DoD supports a really wide range of research, from biomedical to materials, energy, and computer science. After all, everything can be used to "defend" against an adversary. It is one of the things that the US is still doing right. Lots of money is poured into basic research. Not all of them are used to build tanks and warships.
Yeah, my first programming gig was doing research for an open source DoD compilers project (ROSE) run by the DOE at LLNL