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A New Mode of Cancer Treatment

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Re: A New Mode of Cancer Treatment

#171

Post by cmrdporcupine »

ajmurmann wrote: post #78
treprinum wrote: post #8

Earlier quoted context omitted.

There is still the threat of WW3...

Nuclear war, maybe. WWIII would require two global superpowers, not a global superpowers and a country with the GDP of Greece that's struggling to remain a regional power.

Entirely depends on where China sits in this discussion.

Luckily despite the last ten years of decline in relations and shift in China's positioning, the PRC still seems mostly motivated by trade rather than dick-measuring contests. Let's hope that continues.

Re: A New Mode of Cancer Treatment

#174

Post by ajmurmann »

dragonwriter wrote: post #107
ajmurmann wrote: post #78

Earlier quoted context omitted.

Nuclear war, maybe. WWIII would require two global superpowers, not a global superpowers and a country with the GDP of Greece that's struggling to remain a regional power.

> WWIII would require two global superpowers, No, it wouldn’t. You can have a World War without global superpowers on both sides (you need a wide geographic alignment of such power to, balanced for the relative difficulty of force projection on both sides, reach aggregate near-parity across a widely geographically dispersed set of conflict theaters, but you can do that with a global superpower on one side and a coali…

So it's NATO against Russia, Belarus and who?

Re: A New Mode of Cancer Treatment

#175

Post by rtsil »

wiredfool wrote: post #45
jaggederest wrote: post #29

Earlier quoted context omitted.

One of the classics, his take on Chlorine Trifluoride (!!!!) https://www.science.org/content/blog-post/sand-won-t-save-yo... "It is also hypergolic with such things as cloth, wood, and test engineers, not to mention asbestos, sand, and water --- with which it reacts explosively." - John D Clark, Ignition!: An Informal History of Liquid Rocket Propellants

That’s a very interesting book if you have a passing knowledge of chemistry. Findable on the web in pdf form.

I have a rusty, high-school knowledge of chemistry and Ignition made me love it (well, the part of it that is prone to explosion and corrosion). And I confirm, it's available in paper form.

Re: A New Mode of Cancer Treatment

#176

Post by lacrimacida »

ajuc wrote: post #65
lacrimacida wrote: post #52

Earlier quoted context omitted.

> Nobody here takes it seriously. A downfalling desperate Putin is likely to cause serious damage with nuclear weapons. I think should be very cautios, but am not suggesting we should giving in to his his nuclear erection. The doomsday clock is 90 seconds to midnight for a reason.

Putin couldn't even force his army to stop 500 people going on Moscow. Had to negotiate, losing face in his own empire. But he will surely have enough influence to force the same army to commit nuclear suicide on his dying whim :) It's just a threat to make west slightly less likely to help Ukraine for real. If people stopped falling for it 10 years earlier we wouldn't have been in this predicament, millions of peopl…

I agree and yet im feeling very uneasy about a vindictive cornered bully like Putin

Re: A New Mode of Cancer Treatment

#177

Post by panabee »

mallomarmeasle wrote: post #34
flobosg wrote: post #12

Earlier quoted context omitted.

Right! I forgot about good ol’ Lipinski: https://en.wikipedia.org/wiki/Lipinski%27s_rule_of_five

Note that a number of well-known drugs violate Lipinski's rules. For instance, digoxin is absorbed by transporters and violates 2 rules. Atorvastatin is another famous example (again 2 rules violated). I believe that it is absorbed through Peyer's patches in the intestine. https://www.pmf.ni.ac.rs/chemianaissensis/wp-content/uploads...

thanks for sharing these exceptions.

key quote from the linked wikipedia article:

This famous "rule of 5" has been highly influential in this regard, but only about 50% of orally administered new chemical entities actually obey it. [5]

[5] O Hagan S, Swainston N, Handl J, Kell DB (2015). "A 'rule of 0.5' for the metabolite-likeness of approved pharmaceutical drugs". Metabolomics. 11 (2): 323–339. doi:10.1007/s11306-014-0733-z. PMC 4342520. PMID 25750602.

Re: A New Mode of Cancer Treatment

#179

Post by dragonwriter »

ajmurmann wrote: post #174
dragonwriter wrote: post #107

Earlier quoted context omitted.

> WWIII would require two global superpowers, No, it wouldn’t. You can have a World War without global superpowers on both sides (you need a wide geographic alignment of such power to, balanced for the relative difficulty of force projection on both sides, reach aggregate near-parity across a widely geographically dispersed set of conflict theaters, but you can do that with a global superpower on one side and a coali…

So it's NATO against Russia, Belarus and who?

Should it expand beyond a major European war: Iran, Syria, North Korea, China are among the more obvious potential out-of-region Russian coalition partners; there's also quite a number of situations in Africa that could also be plausible areas of expansion of the same geopolitical conflict.

Re: A New Mode of Cancer Treatment

#180

Post by hinkley »

lelag wrote: post #2

If 2023 ends up giving us AGI, room-temperature superconductors, Starships and a cure for cancer, I think we will able to call it a good year...

To paraphrase Brett Goldstein, Elon Musk couldn't fucking build Jefferson Starship.

He may get us back into space, but SpaceX won't get us into the solar system. That will come when SpaceX is fat and happy and complacent, and some new company comes in and does to them what they've done to others.

And none of us will be alive when a human orbits another star. We might see someone launch, but we won't live to see if they survived the journey.

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